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Topic: Vancomycin


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In the News (Sat 26 Jul 08)

  
  Vancomycin - Wikipedia, the free encyclopedia
Vancomycin is an antibiotic used in the prophylaxis and treatment of infections caused by Gram-positive bacteria.
Vancomycin has traditionally been considered a nephrotoxic and ototoxic drug, based on observations by early investigators of elevated serum levels in renally impaired patients who had experienced ototoxicity, and subsequently through case reports in the medical literature.
However, as the use of vancomycin increased with the spread of MRSA beginning in the seventies, it was recognized that the previously reported rates of toxicity were not being observed.
en.wikipedia.org /wiki/Vancomycin   (1533 words)

  
 MedlinePlus Drug Information: Vancomycin (Systemic)   (Site not responding. Last check: 2007-10-13)
Vancomycin is used to treat infections in many different parts of the body.
Vancomycin also is used in patients with heart valve disease (e.g., rheumatic fever) or prosthetic (artificial) heart valves who are allergic to penicillin.
Vancomycin given by injection is used mainly for serious infections for which other medicines may not work.
www.nlm.nih.gov /medlineplus/druginfo/uspdi/202590.html   (1199 words)

  
 Vancomycin   (Site not responding. Last check: 2007-10-13)
Vancomycin was initially approved for use by the FDA in 1964.
Vancomycin is particularly useful against penicillin- and methicillin-resistant staphylococcal infections and for treating gram-positive infections in penicillin-allergic patients.
Vancomycin is useful against a wide variety of clinical infections due to these organisms, although it should not be used in patients with meningitis due to poor penetration into CSF.
www.cai.mcgill.ca /meded/drugdb/vancomycin/vancomycin_db.htm   (2546 words)

  
 Vancomycin: Controversial use in Autism   (Site not responding. Last check: 2007-10-13)
Vancomycin is a distinct class of antiobiotics unrelated to the family of penicillins, streptomycin, cephalosporins, quinolones, sulfonamides, erythromycin, etc. that we use routinely in medical practice.
Vancomycin is a macrolide glycopeptide class of antibiotic.
Vancomycin is one of our main-stays against multi-drug resistant life threatening infection with Staphylococcus aureas or antibiotic induced large gut infection.
www.udaan.org /drugs/vancocin.html   (694 words)

  
 Characterization of Passage-Selected Vancomycin-Resistant Staphylococcus aureus Strains of Diverse Parental Backgrounds ...
Assessment of vancomycin removal from the medium by whole cells was derived from the methodology of Sieradzki and Tomasz (31).
of 4 µg/ml (one-half the vancomycin MIC for COLV
Increase in glutamine-non-amidated muropeptides in the peptidoglycan of vancomycin-resistant Staphylococcus aureus strain Mu50.
aac.asm.org /cgi/content/full/44/2/294   (6495 words)

  
 Vancomycin dosing review
Vancomycin is not removed appreciably by hemodialysis and thus is administered only every 7 to 10 days in dialysis patients.
Because vancomycin exhibits a multi-compartment pharmacokinetic profile, the clinical application of the one-compartment model requires post-distribution serum samples which are often difficult to accurately obtain.
Vancomycin pharmacokinetics are highly variable, it is a difficult drug to model empirically, look at the divergent methods in the literature.
www.rxkinetics.com /vanco.html   (2277 words)

  
 the Drug Monitor- Vancomycin - Nasr Anaizi, PhD
Oral vancomycin is used only for the treatment of antibiotic-induced pseudomembranous colitis, which is caused by a toxin produced by Clostridium Difficile, a spore-forming, G(+) obligate anaerobic bacillus.
The dosing interval is adjusted to achieve and maintain a target trough level between 8 and 20 mg/L depending on the severity and location of the infection (the higher targets may be necessary for the treatment of CNS and bone infections).
The side effects of iv vancomycin include a histamine-mediated erythematous flushing of the face, neck and trunk, a reaction which occurs during the infusion, and may be associated with hypotension.
www.thedrugmonitor.com /vanco.html   (1238 words)

  
 vancomycin. The Columbia Encyclopedia, Sixth Edition. 2001-05
Vancomycin destroys Gram-positive bacteria, especially staphylococci and enterococci (see Gram’s stain).
The drug is intensely irritating to tissues and is usually used only for infections where microorganisms are resistant to penicillin (see drug resistance).
Vancomycin must be administered intravenously because it is not absorbed through the gastrointestinal tract.
www.bartleby.com /65/va/vancomyc.html   (153 words)

  
 Facts about vancomycin-resistant enterococci (VRE)   (Site not responding. Last check: 2007-10-13)
However, only penicillins, or teicoplanin and vancomycin (two expensive and potentially toxic antibiotics which can only be given by injection) are reliably effective against serious enterococcal infections such as endocarditis or meningitis.
The genetic material which makes enterococci resistant to vancomycin has probably been passed on from other types of bacteria that do not cause human disease but which are already vancomycin-resistant.
Bacteria that are resistant to vancomycin are commonly also resistant to a similar antibiotic called teicoplanin, and vice versa.
www.amm.co.uk /newamm/files/factsabout/fa_vre.htm   (872 words)

  
 Vancomycin Use in Hospitalized Pediatric Patients -- Keyserling et al. 112 (2): 104 -- Pediatrics
27% of all vancomycin was administered to neonates; 94% of the
Vancomycin resistance in Staphylococcus haemolyticus causing colonization and bloodstream infection.
The epidemiology of vancomycin usage in a university hospital.
pediatrics.aappublications.org /cgi/content/full/112/2/e104   (4089 words)

  
 Vancomycin   (Site not responding. Last check: 2007-10-13)
[1] Vancomycin is now seen as the last-resort drug because it is often the last opportunity that a physician may have to eliminate a bacterial infection, since bacteria have become resistant to so many other drugs.
The vancomycin family of antibiotics inhibits this stage of cell wall synthesis.
Vancomycin therefore has much more of a difficulty in binding to its substrate and is rendered ineffective.
www.molbio.princeton.edu /courses/mb427/2001/projects/02/vancomycin.htm   (1275 words)

  
 vancomycin Drug Information
Orally administered vancomycin is used to treat infections of the intestines.
Vancomycin is in the FDA pregnancy category C. This means that it is not known whether vancomycin will be harmful to an unborn baby.
Vancomycin is available as oral capsules, an oral solution, and as an intravenous injection.
www.drugs.com /MTM/vancomycin.html   (1174 words)

  
 vancomycin news articles   (Site not responding. Last check: 2007-10-13)
Dr Millar said the strain was susceptible to vancomycin, an antibiotic commonly used in the hospital.
...we are giving vancomycin to one lady twice a day, and to show her thanks she bought us a huge cake that said "thank you for helping" and flowers to put on our...
And Vancomycin Resistant Enteroccci was found in one in 25 of the samples, although more tests would be needed to confirm the exact type of the bug found, the...
www.mongabay.com /drugs/drugs/vancomycin.html   (9286 words)

  
 Postgraduate Medicine: Recurrent Clostridium difficile colitis
Vancomycin and metronidazole kill the vegetative form of C difficile but do not kill the spores (8), which can germinate and eventually produce toxins.
Tapering the dose of vancomycin or metronidazole over 4 to 6 weeks has been shown to be effective.
Vancomycin in combination with rifampin (Rifadin, Rimactane) or oral bacitracin also has been found to be effective against recurrent C difficile infection (15).
www.postgradmed.com /issues/2002/11_02/joyce3.htm   (2544 words)

  
 Vancomycin   (Site not responding. Last check: 2007-10-13)
To treat severe bacterial infections such as colitis (infection and inflammation of the colon); also used prior to surgical or dental procedures to prevent heart valve infection in susceptible patients (for example, those with a history of rheumatic fever or heart valve replacement) who are allergic to penicillin.
Vancomycin kills and inhibits the growth of bacteria by interrupting their formation of cell walls.
Before using vancomycin, consult your doctor if you are pregnant or plan to become pregnant.
www.wholehealthmd.com /print/view/1,1560,DR_629,00.html   (604 words)

  
 First Report of Methicillin-Resistant Staphylococcus aureus with Reduced Susceptibility to Vancomycin in Thailand -- ...
Vancomycin is a useful antibiotic against gram-positive pathogens.
Vancomycin in surgical infections due to methicillin-resistant Staphylococcus aureus with heterogeneous resistance to vancomycin.
The emergence of decreased susceptibility to vancomycin in Staphylococcus epidermidis.
jcm.asm.org /cgi/content/full/39/2/591   (3081 words)

  
 Staphylococcus aureus Resistant to Vancomycin --- United States, 2002
The vancomycin minimum inhibitory concentration (MIC) result reported for this isolate was in the intermediate range (vancomycin MIC=8 µg/mL) using interpretive criteria defined by the National Committee for Clinical Laboratory Standards (4).
The infection was treated with vancomycin, rifampin, and removal of the infected graft.
The isolate contained the vanA vancomycin resistance gene from enterococci, which is consistent with the glycopeptide MIC profiles.
www.cdc.gov /mmwr/preview/mmwrhtml/mm5126a1.htm   (1323 words)

  
 Vancomycin   (Site not responding. Last check: 2007-10-13)
Vancomycin is often described as the antibiotic of last resort.
For July's molecule of the Month, we describe how vancomycin works as an antibiotic, and how bacteria resistant to other antibiotics can be killed using vancomycin.
Finally, two major concerns are brought up: the development of vancomycin resistance and the difficulties of producing vancomycin on an industrial scale.
www.chm.bris.ac.uk /motm/vancomycin/intro.htm   (82 words)

  
 Vancomycin-Resistant Enterococci -- Cetinkaya et al. 13 (4): 686 -- Clinical Microbiology Reviews
Vancomycin had been in clinical use for more than 30 years without the emergence of marked resistance (129).
Oral vancomycin use may also be a risk factor for VRE colonization (29, 147, 165), and this has led to recommendations
Vancomycin use in hospitals increased significantly over the 1980s (165).
cmr.asm.org /cgi/content/full/13/4/686   (9289 words)

  
 Vancomycin-resistant staph aureus?   (Site not responding. Last check: 2007-10-13)
In Japan, a child recovering from heart surgery acquired a staph infection that was not knocked down by the usual vancomycin treatment.
This first case of a staph infection resistant to vancomycin "is something that we in CDC and most people in medicine have been expecting for some time," said Tom Skinner of the CDC.
Just eight years ago, vancomycin failed only 0.3 percent of the time in treating infections caused by a family of bacteria called enterococci.
www.psych-health.com /staph.htm   (610 words)

  
 ScienceDaily: Rice Uses Buckyballs To Reinvent 'Antibiotic Of Last Resort'; New Drug Could Become First Targeted ...   (Site not responding. Last check: 2007-10-13)
Vancomycin, which entered clinical service 40 years ago, is the antibiotic of last resort, given only when all others fail.
In an effort to reinvigorate vancomycin, researchers have created vancomycin conjugates -- pairs of vancomycin molecules joined by an intermediate molecule that acts as a bridge -- some of which have proven more effective at killing resistant bacteria.
However, having the ability to affix the antibiotic to a spore could enable the drug to knock the disease out when it tries to emerge from hibernation, before it has a chance to spread throughout the body and release its toxins.
www.sciencedaily.com /releases/2003/04/030418081522.htm   (883 words)

  
 Vancocin Online, Description, Chemistry, Ingredients - Vancomycin - RxList Monographs
HCl (Vancomycin Injection, USP) in the GALAXY plastic container (PL 2040) contains Vancomycin, USP as vancomycin hydrochloride.
It is a tricyclic glycopeptide antibiotic derived from Amycolatopsis orientalis (formerly Nocardia orientalis).
HCl (Vancomycin Injection, USP) in the GALAXY plastic container (PL 2040) is a frozen, iso-osmotic, sterile, nonpyrogenic premixed 100 mL or 200 mL solution containing 500 mg or 1 g Vancomycin, USP respectively as Vancomycin hydrochloride.
www.rxlist.com /cgi/generic2/vancomycin.htm   (277 words)

  
 Vancomycin (Systemic) - MayoClinic.com   (Site not responding. Last check: 2007-10-13)
Vancomycin has not been reported to cause hearing loss or kidney damage in the infants of women given vancomycin during their second or third trimester of pregnancy.
Vancomycin can cause serious side effects in any patient.
Elderly people may be especially sensitive to the effects of vancomycin.
www.mayoclinic.com /health/drug-information/DR202590   (1213 words)

  
 VRE - Vancomycin-Resistant Enterococcus
Vancomycin is a powerful antibiotic that is often the antibiotic of last resort.
Two strains of staph resistant to vancomycin were reported in the U.S. in the summer of 1997, and it is expected that this number will increase rapidly.
The first is that your baby may be exposed to VRE or resistant staph through contact with hospital equipment or personnel.
www.gentlebirth.org /vre/vremain.html   (2995 words)

  
 Enterococci Resistant to Multiple Antimicrobial Agents, Including Vancomycin: Establishment of Endemicity in a ...
Administration of oral and intravenous vancomycin from January 1993 to June 1994 (restrictions on vancomycin use were imposed on 1 December 1993).
vancomycin was not considered to be justified; in 43 [88%] of
Paul J. Weidle and Joseph Gallina for establishing and monitoring compliance with the vancomycin restrictions and for collecting pharmacy data; Sonia Aguero and Dr. Matthew Arduino for hand-culturing studies; and Drs.
www.annals.org /cgi/content/full/123/4/250   (5456 words)

  
 New Scientist Breaking News - New antibiotic-resistant superbug found   (Site not responding. Last check: 2007-10-13)
Doctors in the US have detected the first Staphyloccocus aureus bacteria that are highly resistant to vancomycin, known as the antibiotic of last resort.
The superbugs were found by medical staff treating a 40-year-old hospital patient in Michigan with a leg ulcer.
The American patient survived after treatment with an older antibiotic called chloramphenical, though Livermore says the VRSA's susceptibility to this drug was fortunate.
www.newscientist.com /article.ns?id=dn2581   (393 words)

  
 Vancomycin HCl Drug Information
Lyphocin, Vancocin HCl, Vancocin HCl Pulvules, Vancoled, Vancomycin HCl
Before taking vancomycin, tell your doctor if you have
Your doctor or healthcare provider will administer intravenous vancomycin.
www.drugs.com /MTM/V/Vancomycin_HCl.html   (1200 words)

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