| |
| | eMedicine - Henoch-Schoenlein Purpura : Article Excerpt by Noah S Scheinfeld |
 | | However, Schönlein first described the combination of acute purpura and arthritis in children in 1837, and Henoch reported the manifestations of abdominal pain and nephritis in 1874. |
 | | The dominant clinical features of HSP are cutaneous purpura, arthritis, abdominal pain, GI bleeding, orchitis, and nephritis. |
 | | IgA aggregates or IgA complexes with complement deposited in target organs, resulting in elaboration of inflammatory mediators, including vascular prostaglandins such as prostacyclin, may play a central role in the pathogenesis of HSP vasculitis. |
| www.emedicine.com /ped/byname/henoch-schoenlein-purpura.htm (1340 words) |
|