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Topic: Vasodilator

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	Vasodilator - Wikipedia, the free encyclopedia
		A vasodilator is a substance that causes blood vessels in the body to become wider by relaxing the smooth muscle in the vessel wall, or vasodilation.
		Atrial natriuretic peptide (ANP) - a weak vasodilator.
		Its mild vasodilating effects redden the eyes of cannabis smokers.
	en.wikipedia.org /wiki/Vasodilator (187 words)

	Patent 6,007,836
		The vasodilator is stored and contained in the at least one middle layer of the transdermal patch, which functions as a vasodilator reservoir conventionally in the manner of transdermal medication patches to deliver the vasodilator to the skin surface when the patch is adhered to the skin of the user.
		Vasodilator dispensing can be controlled by controlling the permeability of the relatively more releasable milder adhesive coated on the microhole membrane inner surface, by controlling the thickness of the microhole membrane inner layer, and by varying the size, number and spacing of the microholes.
		The vasodilator material is mixed with a mild adhesive, and the vasodilator-mild adhesive mixture is spread in a thin, slightly moist layer on the inner surface of the condom.
	www.pharmcast.com /Patents/122899OG/6007836_vasodilator122899.htm (6290 words)

	Vasodilator responses to adenosine and hyperemia are mediated by A1 and A2 receptors in the cat vascular bed -- ...
		Vasodilator responses to adenosine and hyperemia are mediated by A
		Vasodilator responses to ATP and the nonhydrolyzable ATP analog
		of vasodilator prostaglandins in mediating responses to adenosine,
	ajpregu.physiology.org /cgi/content/full/282/6/R1696 (6149 words)

	[No title] (Site not responding. Last check: 2007-10-20)
		The vasodilator may be applied as a composition which includes a carrier material with which the vasodilator compound is miscible but which will release the vasodilator active compound when in contact with body tissue.
		A condom according to the invention may also have a vasodilator active compound applied to the interior surface, in order to assist in maintaining an erection of the penis and, thus, providing for additional condom safety in prevention of premature and involuntary unsheathing of the condom from an otherwise partially-erect or flaccid penis.
		A condom according to claim 10, in which the vasodilator active compound comprises an organic nitrate applied as a layer or coating in a polar elastomer in solution, in the form of an aqueous dispersion of latex or by a hot melt or reactive process.
	www.wipo.int /cgi-pct/guest/getbykey5?KEY=03/88880.031030&ELEMENT_SET=DECL (2163 words)

	The Nitric Oxide- and Prostaglandin-Independent Component of the Renal Vasodilator Effect of Thimerosal Is Mediated by ...
		The Nitric Oxide- and Prostaglandin-Independent Component of the Renal Vasodilator Effect of Thimerosal Is Mediated by Epoxyeicosatrienoic Acids -- Chen et al.
		vasodilator responses that were unaffected by inhibition of cyclooxygenase
		We conclude that thimerosal causes vasodilation of the
	jpet.aspetjournals.org /cgi/content/full/304/3/1292 (4380 words)

	Chronic hypoxia opposes pregnancy-induced increase in uterine artery vasodilator response to flow -- Mateev et al. 284 ...
		To evaluate the vasodilator response to flow, flow through the vessel lumen was increased progressively from 0 to 4 µl/s.
		Pregnancy increased UA flow vasodilation in the normoxic animals, but the vasodilator response to flow was not sustained in the vessels from chronically hypoxic animals, resulting in net vasoconstriction at high flow.
		for its involvement is the retention of vasodilator responsiveness
	ajpheart.physiology.org /cgi/content/full/284/3/H820 (5496 words)

	Impaired cerebral vasodilator responses to NO and PDE V inhibition after subarachnoid hemorrhage -- Sobey and Quan 277 ...
		A new finding of the present study is that after SAH cerebral vasodilator responses to zaprinast are impaired in vivo.
		Vasodilator responses to the nonselective PDE inhibitor IBMX were similar in control and SAH animals.
		The effect of subarachnoid hemorrhage on mechanisms of vasodilation mediated by cyclic adenosine monophosphate.
	ajpheart.physiology.org /cgi/content/full/277/5/H1718 (4152 words)

	MUELLER ET AL., BEDSIDE RIGHT HEART CATHETERIZATION - Indications and Recommendations for Use of Bedside RHC
		Several studies (101,106-120a) have correlated the pattern of acute hemodynamic response with long-term prognosis and the clinical response to long-term vasodilator therapy.
		The optimal response to vasodilator therapy is generally considered to be a decrease in pulmonary artery pressure and pulmonary vascular resistance and an increase in cardiac output, without hypoxemia, tachycardia or an excessive decrease in systemic arterial pressure.
		Long-term vasodilator therapy is also considered when there is a decrease only in pulmonary vascular resistance, without a major decrease in pulmonary artery pressure.
	www.acc.org /Clinical/consensus/catheter/jac5803fla56.htm (282 words)

	Pulmonary Hypertension Association
		The magnitude of acute vasodilator response that predicts a favorable outcome with long-term CCB therapy remains poorly defined.
		We therefore consider that a positive response to acute vasodilator challenge is defined by a substantial reduction in mPAP (decrease exceeding 10 mm Hg to reach an mPAP lower than 40 mm Hg) with a normal or high cardiac output.
		In the therapeutic approach of patients with PAH, numerous vasodilator agents have been used on a short-term basis to evaluate the capacity of the pulmonary vascular bed to vasodilate.
	www.phassociation.org /Medical/Advances_in_PH/Autumn_2003/acute.asp (766 words)

	Myenteric neurons activate submucosal vasodilator neurons in guinea pig ileum -- Vanner 279 (2): 380 -- AJP - ...
		Myenteric neurons activate submucosal vasodilator neurons in guinea pig ileum -- Vanner 279 (2): 380 -- AJP - Gastrointestinal and Liver Physiology
		B: summary of the mean vasodilator responses obtained in preparations in which 5-HT was first applied in the presence of TTX (1 µM) and then alone, after a 10-min washout of TTX (n = 5).
		Substance P mediates neurogenic vasodilation in extrinsically denervated guinea-pig submucosal arterioles.
	ajpgi.physiology.org /cgi/content/full/279/2/G380 (4038 words)

	Contribution of 20-HETE to the vasodilator actions of nitric oxide in renal arteries -- Alonso-Galicia et al. 275 (3): ...
		Contribution of cGMP to the dilator response to SNP in isolated perfused renal arterioles.
		B: effect of various concentrations of 8-bromo-cGMP on the vasodilator response to SNP in isolated, perfused rat renal arterioles preconstricted with phenylephrine (1 µM).
		Blockade of the cGMP pathway in renal microvessels
	ajprenal.physiology.org /cgi/content/full/275/3/F370 (5826 words)

	Calcitonin gene-related peptide acts as a novel vasodilator neurotransmitter in mesenteric resistance vessels of the rat (Site not responding. Last check: 2007-10-20)
		, it is not known whether vasodilator nerves contribute to the regulation of the peripheral resistance vessels.
		We present pharmacological evidence for the existence of nonadrenergic, non-cholinergic (NANC) vasodilator nerves in the mesenteric resistance vessel of the rat and that the resistance is controlled by not only sympathetic vasoconstrictor nerves but also NANC vasodilator nerves.
		This indicates that CGRP is a novel vasodilator neurotransmitter and may play a role in control of the total peripheral resistance of systemic circulation through a local reflex mechanism.
	www.nature.com /cgi-taf/DynaPage.taf?file=/nature/journal/v335/n6186/abs/335164a0.html (304 words)

	Decreased Vasodilator Response to Isoproterenol During Nitric Oxide Inhibition in Humans -- Cardillo et al. 30 (4): 918 ...
		contrast, the vasodilator response to sodium nitroprusside was
		Impaired endothelium-dependent vasodilation in patients with essential hypertension: evidence that the abnormality is not at the muscarinic receptor level.
		Impaired endothelium-dependent vasodilation in patients with essential hypertension: evidence that nitric oxide abnormality is not localized to a single signal-transduction pathway.
	hyper.ahajournals.org /cgi/content/full/30/4/918 (2696 words)

	Prolonged head-down tilt exposure reduces maximal cutaneous vasodilator and sweating capacity in humans -- Crandall et ...
		Cutaneous vasodilation and sweat rate are reduced during a thermal challenge after simulated and actual microgravity exposure.
		Assessment of maximal cutaneous vasodilation was accomplished by exposing the subject's left forearm to 42°C for 45 min by
		Hindlimb unweighting alters endothelium-dependent vasodilation and ecNOS expression in soleus arterioles.
	jap.physiology.org /cgi/content/full/94/6/2330 (4057 words)

	UpToDate Vasodilator therapy in asymptomatic severe chronic aortic regurgitation in adults
		Clinical trials indicate that vasodilator therapy in asymptomatic patients with severe chronic AR may slow the rate of progression of the hemodynamic burden, thereby reducing the changes in LV size and function and delaying the onset of symptoms and therefore the need for corrective surgery.
		Vasodilator therapy is directed at reducing the regurgitant volume, but such therapy may have other nonspecific beneficial effects.
		As will be described below, vasodilator therapy is considered only in patients with severe chronic AR and LV dilation (show table 3) [1].
	patients.uptodate.com /topic.asp?file=valve_hd/2096 (473 words)

	Antihypertensive, vasodilator and antioxidant effects of a vinifera grape skin extract
		The vasodilator effect of GSE (polyphenols concentration 55.5 mg g-1) was also assessed in the isolated mesenteric vascular bed of Wistar rats and the antioxidant effect was studied on lipid peroxidation of hepatic microsomes.
		In conclusion, the antihypertensive effect of GSE might be owing to a combination of vasodilator and antioxidant actions of GSE.
		These findings also suggest that the beneficial effect of moderate red wine consumption could be owing to an antihypertensive action induced by compounds occurring in the skin of vinifera grapes.
	www.aapspharmaceutica.com /search/view.asp?ID=37278 (268 words)

	Contribution of 20-HETE to Vasodilator Actions of Nitric Oxide in the Cerebral Microcirculation • Editorial Comment -- ...
		pathway to the NO-induced vasodilation of rat cerebral arteries.
		The conclusion that the NO-induced vasodilation of cerebral
		Halothane vasodilation and nitric oxide in rat pial vessels.
	stroke.ahajournals.org /cgi/content/full/30/12/2727 (5639 words)

	Impairment of Vasodilator Function in Basilar Arteries From Aged Rats -- Arribas et al. 28 (9): 1812 -- Stroke
		The aim of this study was to determine the effect of aging on vasodilator
		Decreased ß-adrenoceptor-mediated vasodilation in aorta from aged rats: possible involvement of a stimulatory GTP-binding protein.
		Reduced vasodilator responses to noradrenaline correlate with decreased density of ß-adrenoceptor fluorophore binding in the basilar artery from old WKY rats.
	stroke.ahajournals.org /cgi/content/full/28/9/1812 (4659 words)

	Pertil Retard (isosorbide-5-mononitrate) - vasodilator - prevents angina
		Imdur contains the medicine isosorbide-5-mononitrate, which is a vasodilator that relaxes and widens blood vessels.
		This is chest pain caused by not enough oxygen reaching the heart muscle, due to disease of the coronary arteries that supply it.
		Any medical information on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional.
	www.patienthealthinternational.com /product/2381.aspx (133 words)

	Vasodilator effects of L-arginine are stereospecific and augmented by insulin in humans -- Dallinger et al. 284 (6): ...
		Vasodilator effects of L-arginine are stereospecific and augmented by insulin in humans -- Dallinger et al.
		The aim of the present study was to gain further insight into the mechanism underlying the vasodilator effect of
		Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent.
	ajpendo.physiology.org /cgi/content/full/284/6/E1106 (2653 words)

	Vascular effects of arachidonic acid in the rat perfused heart: role of the endothelium, cyclooxygenase, cytochrome ...
		Recording of perfusion pressure (PP) showing vasodilator responses to arachidonic acid (AA) and bradykinin (BK) in a heart in which perfusion pressure was elevated with U46619 (10 ng/ml).
		Oyekan, A. O., McGiff, J. C., Quilley, J. Cytochrome P450-dependent vasodilator responses to arachidonic acid in the isolated perfused kidney of the rat.
		Fulton, D., Quilley, J. Evidence against anandamide as the hyperpolarizing factor mediating the nitric oxide-independent coronary vasodilator effect of bradykinin in the rat.
	www.jlr.org /cgi/content/full/40/12/2177 (4246 words)

	Prostaglandin E1 as a screening vasodilator in primary pulmonary hypertension -- Halpern et al. 92 (4): 686 -- Chest
		Prostaglandin E1 as a screening vasodilator in primary pulmonary hypertension -- Halpern et al.
		Prostaglandin E1 as a screening vasodilator in primary pulmonary hypertension
		Pulmonary vasodilators are variably efficacious in primary pulmonary
	www.chestjournal.org /cgi/content/abstract/92/4/686 (217 words)

	Effects of coronary revascularisation on myocardial blood flow and coronary vasodilator reserve in hibernating ...
		Effects of coronary revascularisation on myocardial blood flow and coronary vasodilator reserve in hibernating myocardium -- Pagano et al.
		Effects of coronary revascularisation on myocardial blood flow and coronary vasodilator reserve in hibernating myocardium
		Figure 5 Comparison of coronary vasodilator reserve between hibernating, remote (before and after revascularisation), and control myocardial segments.
	heart.bmjjournals.com /cgi/content/full/85/2/208 (2575 words)

	JAMA -- Abstract: Vasodilator therapy for heart failure. Concepts, applications, and challenges, February 20, 1981, ...
		JAMA -- Abstract: Vasodilator therapy for heart failure.
		Vasodilators are widely used in the treatment of heart failure patients
		As a result of vasodilation, preload and afterload reduction can improve
	jama.ama-assn.org /cgi/content/abstract/245/7/761 (130 words)

	Viagra for Impotence of Pulmonary Vasodilator Therapy? -- Lodato 163 (2): 312 -- American Journal of Respiratory and ...
		Nearly all pulmonary vasodilators are also systemic vasodilators.
		MandB 22948, a cGMP phosphodiesterase inhibitor, is a pulmonary vasodilator in lambs.
		Influence of Zaprinast on vascular tone and vasodilator responses in the cat pulmonary vascular bed.
	ajrccm.atsjournals.org /cgi/content/full/163/2/312 (1241 words)

	Vasodilator responses to adenosine and hyperemia are mediated by A1 and A2 receptors in the cat vascular bed -- ...
		Vasodilator responses to adenosine and hyperemia are mediated by A1 and A2 receptors in the cat vascular bed -- Bivalacqua et al.
		Vasodilator responses to adenosine were reduced by KW-3902, CGS-15943,
		and duration of the reactive vasodilator response were reduced
	ajpregu.physiology.org /cgi/content/abstract/282/6/R1696 (317 words)

	Inhaled iloprost is a potent acute pulmonary vasodilator in HIV-related severe pulmonary hypertension -- Ghofrani et ...
		Inhaled iloprost is a potent acute pulmonary vasodilator in HIV-related severe pulmonary hypertension -- Ghofrani et al.
		Inhaled iloprost is a potent acute pulmonary vasodilator in HIV-related severe pulmonary hypertension
		In conclusion, inhaled iloprost is a potent pulmonary vasodilator
	erj.ersjournals.com /cgi/content/abstract/23/2/321 (366 words)

	Blunting of Pulmonary but not Systemic Vasodilator Responses to Dobutamine in Newborn Lambs -- SMOLICH et al. 47 (1): ... (Site not responding. Last check: 2007-10-20)
		vasodilator response to dobutamine in 1- to 2-d-old lambs was
		vasodilation occurring with dobutamine is not apparent for at
		of pulmonary vasodilator responses with an elevation of PABP
	www.pedresearch.org /cgi/content/full/47/1/107 (3570 words)

	Papaverine, a vasodilator with antiviral activity (Site not responding. Last check: 2007-10-20)
		Koch HJ Papaverine, a vasodilator with antiviral activity.
		The patient’s pulmonary hypertension improved clinically after treatment with a combination of a nucleoside analogue and a protease inhibitor, and no vasodilatory therapy was necessary.
		However, if a vasodilator is considered of potential use in HIV patients with pulmonary arterial hypertension, papaverine may be a suitable therapeutic approach.
	www.smw.ch /archive200x/2002/07/smw-09951.html (472 words)

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