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| | VENLAFAXINE |
 | | Venlafaxine, a phenylethylamine bicyclic antidepressant, is a serotonin and noradrenaline reuptake inhibitor. |
 | | Out of 14 reported cases of venlafaxine acute overdoses two patients were reported to have developed a mild sinus tachycardia and a third patient was reported to have a prolongation of QTc to 500 msec, compared with 405 msec at baseline (Prod Info Effexor(R), 2000). |
 | | It is postulated that venlafaxine, a cytochrome P450 inhibitor, may inhibit the metabolism of desipramine, causing an increase in the serum concentration of desipramine and resulting in the anticholinergic syndrome (Benazzi, 1998). |
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