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Topic: Vincristine

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	Oncovin Online, Description, Chemistry, Ingredients - Vincristine Sulfate - RxList Monographs
		Vincristine Sulfate Injection is the salt of an alkaloid obtained from a common flowering herb, the periwinkle plant (Vinca rosea Linn).
		Vincristine sulfate is a white to off-white powder.
		Vincristine Sulfate Injection, USP is a sterile, preservative-free, single use only solution available for intravenous use in 2 mL (1 mg and 2 mg) vials.
	www.rxlist.com /cgi/generic3/vincristine.htm (316 words)

	Oncology Nursing Society.
		Vincristine sulfate is the salt of an alkaloid obtained from a flowering herb, the Madagascar periwinkle plant (Catharanthus roseus, formerly classified as Vinca rosea Linn, which caused it to be called a vinca alkaloid) (Greuter et al., 1999).
		Vincristine inhibits microtubule formation in the mitotic spindle, resulting in the arrest of dividing cells at the metaphase stage and, because of this action, sometimes is referred to as an antimicrotubule agent.
		Dispensing vincristine in small-volume infusion bags or diluting the dose to at least 10 ml to help differentiate it from intrathecal drugs, for which such a large volume is not given, may help to reduce the potential for inadvertent intrathecal vincristine administration.
	www.ons.org /Publications/journals/ONF/Volume31/Issue5/3105897.asp (5121 words)

	Vincristine (Oncovin, Vincasar) - VeterinaryPartner.com - a VIN company!
		Vincristine is chiefly used as one drug in multi-drug combination protocols against lymphoid and round cell tumors.
		Vincristine is highly irritating to the soft tissues and if it is not given intravenously, where the bloodstream rapidly carries it away and dilutes it within the body's blood volume, it will cause what is called a tissue slough.
		Vincristine is not able to pass through the blood/brain barrier and thus cannot treat tumors in the nervous system.
	www.veterinarypartner.com /Content.plx?P=A&A=1645&S=1 (488 words)

	Vincristine (Systemic) - MayoClinic.com (Site not responding. Last check: 2007-10-08)
		Vincristine interferes with the growth of cancer cells, which are eventually destroyed.
		Vincristine is to be administered only by or under the immediate supervision of your doctor.
		Vincristine may lower your body's resistance and there is a chance you might get the infection the immunization is meant to prevent.
	www.mayoclinic.com /health/drug-information/DR202594 (1501 words)

	Vincristine
		Vincristine is one of the older chemotherapy drugs which has been around for many years.
		When prepared for use, it becomes a clear and colorless liquid and is given by intravenous route only.
		The degree and severity of the side effects depend on the amount and schedule of the administration of Vincristine.
	www.tirgan.com /vincristine.htm (135 words)

	Vincristine Sulphate - Serum Institute of India.
		VINCRISTINE SULPHATE is the salt of an alkaloid obtained from a common flowering herb, the periwinkle plant.
		VINCRISTINE SULPHATE appears to bind to or crystallize critical microtubular proteins of the mitotic spindle, thus preventing their proper polymerization and causing metaphase arrest.
		VINCRISTINE SULPHATE has also been shown to be useful in combination with other oncolytic agents in Hodgkin's disease, non-Hodgkin's malignant lymphomas (lymphocytic, mixed -cell histolytic, undifferentiated, nodular, and diffuse types) rhabdomyosarcoma, neuroblastoma and Wilms tumor.
	www.seruminstitute.com /content/products/product_vincristinesulphate.htm (1932 words)

	Drug safety experts stunned by vincristine-related death - Drug Topics
		Instead of being given intravenously, vincristine, a chemotherapy agent used to treat certain types of leukemia, was delivered intrathecally.
		Trissel asserted that many of the errors involving vincristine occur because it is usually a part of a multidrug regimen that includes agents that are supposed to be administered intrathecally.
		Packaging vincristine doses in minibags is a good idea too because minibags are incompatible with intrathecal drug delivery, thereby providing a physical barrier to accidental intrathecal injection.
	www.drugtopics.com /drugtopics/article/articleDetail.jsp?id=110937 (764 words)

	vincristine of Augusta, Georgia
		Vincristine should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.
		Vincristine interferes with the growth of cancer cells and slows their growth and spread in the body.
		Vincristine is in the FDA pregnancy category D. This means that vincristine is known to be harmful to an unborn baby.
	www.universityhealth.org /17095.cfm (1046 words)

	Liposome Research Unit - Abstract 183 (Site not responding. Last check: 2007-10-08)
		Vincristine is a potent therapeutic agent with activity against a variety of tumor types.
		Vincristine can be encapsulated into large unilamellar vesicles in response to a transmembrane pH gradient with trapping efficiencies approaching 100%.
		The extent of vincristine encapsulation, and the subsequent retention of the drug within the liposomes, both in vitro and in vivo, are strongly dependent on the lipid composition of the liposome and on the magnitude of the transmembrane pH gradient.
	www.liposomes.ubc.ca /abstracts/183.html (236 words)

	Healthopedia.com Drugs Information - Vincristine : Before Using (Oncovin, Vincasar PFS, Vincrex)
		There is a chance that this medicine may cause birth defects if either the male or female is taking it at the time of conception or if it is taken during pregnancy.
		Vincristine causes birth defects and death of the fetus in animals.
		Because vincristine may cause serious side effects, breast-feeding is generally not recommended while you are receiving it.
	www.healthopedia.com /drugs/detailed/vincristine/before-using.html (649 words)

	Vincristine factsheet (Site not responding. Last check: 2007-10-08)
		This factsheet explains what vincristine is, how it is given and some of the possible side effects.
		Vincristine is a drug which is used to treat leukaemia and some solid tumours.
		This is because of the effect of vincristine on the cranial nerve, which runs down the side of the face.
	www.gosh.nhs.uk /factsheets/families/F000149 (560 words)

	Vincristine (Oncovin)
		Vincristine is used to treat a wide variety of cancers including breast cancer and lung cancer, as well as non Hodgkin's lymphoma and leukaemia.
		Vincristine is a clear liquid that you have by injection (intravenously) or drip (infusion) through a fine tube (cannula) put into a vein.
		Vincristine may have a harmful effect on a baby developing in the womb.
	www.cancerhelp.org.uk /help?page=4019 (1271 words)

	MedlinePlus Drug Information: Vincristine
		Vincristine is in a class of drugs known as vinca alkaloids.
		Vincristine is also used to treat some types of sarcoma, small cell lung cancer, osteogenic sarcoma, Ewing's sarcoma, Burkitt's lymphoma, brain medulloblastoma, multiple myeloma, idiopathic thrombocytopenia purpura, and autoimmune hemolytic anemia.
		A common side effect of vincristine is a decrease of blood cells.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a682822.html (517 words)

	Institute for Safe Medication Practices
		Even if vincristine is properly labeled and packaged, clinical personnel may dangerously remove the drug from its overwrap in advance of IV injection.
		If vincristine is near an intrathecal medication during the drug administration process, the physician, focused on performing a lumbar puncture, maintaining sterility, and preventing patient movement, may overlook the syringe label and accidentally pick up the intrathecal medication.
		Accrediting and regulatory bodies should provide oversight to assure that facilities where chemotherapy is given have policies and procedures in place that are being followed to prevent accidental intrathecal injection of IV drugs.
	www.ismp.org /msaarticles/intrathecalvinca.html (496 words)

	Vincristine (Site not responding. Last check: 2007-10-08)
		Vincristine: is a drug that belongs to the group of medicines known as antieoplastic agents.
		Vincristine is administered by injection, typically with a central venous line called a port-o-cath.
		Vincristine may lower your body's resistance to infection and increase the chances of getting the disease the immunization is designed to protect you from.
	www.novanews.org /VincristineGuide.htm (560 words)

	Vincristine: BC Cancer Agency
		Vincristine has produced severe hepatic toxicity when given in conjunction with abdominal radiation therapy.
		It is the primary and dose-limiting toxicity of vincristine.
		Vincristine with preservative diluted in 20 mL NS in a 30 mL syringe or 25-50 mL NS in mini-bags have been reported to be stable for 7 days under refrigeration followed by 2 days at room temperature.
	www.bccancer.bc.ca /HPI/DrugDatabase/DrugIndexPro/Vincristine.htm (1882 words)

	In Vitro and in Vivo Characterization of Doxorubicin and Vincristine Coencapsulated within Liposomes through Use of ... (Site not responding. Last check: 2007-10-08)
		and vincristine was administered in one injection of 200 µl.
		Doxorubicin or vincristine encapsulation in 1,2 distearoyl-sn-glycero-3-phosphocholine/cholesterol (55/45 mol%) liposomes using (A and C) the manganese-sulfate loading procedure alone or (B and D) with A23187.
		Vincristine was added to the liposomes to achieve a 0.05:1.0 (wt:wt) drug:lipid ratio.
	clincancerres.aacrjournals.org /cgi/content/full/10/2/728 (6898 words)

	Cancerquest: Vincristine (Site not responding. Last check: 2007-10-08)
		By binding to the building blocks of microtubules, vincristine disables the cell's mechanism for aligning and moving the chromosomes.
		Vincristine stops the separation of the duplicated chromosomes and prevents cell division.
		Vincristine is administered intravenously and is used to treat many different types of cancer.
	www.cancerquest.org /printfriendly.cfm?printpage=523 (232 words)

	Lymphoma Information Network - Vincristine
		Vincristine (also called Oncovin or VCR) is a chemotherapy agent used in the treatment of Non-Hodgkin's lymphoma and Hodgkin's Disease.
		Both vinblastine and vincristine are used in the Stanford V regimen whereas vincristine alone is used in CHOP.
		URL: The Pharmacology of Vinblastine, Vincristine, Vindesine, and Vinorelbine from Cyberbotanica by Lucy A. Snyder
	www.lymphomainfo.net /therapy/drugs/vincristine.html (484 words)

	Pharmacokinetics of Vincristine Monotherapy in Childhood Acute Lymphoblastic Leukemia -- GRONINGER et al. 52 (1): 113 ... (Site not responding. Last check: 2007-10-08)
		Pharmacokinetics of Vincristine Monotherapy in Childhood Acute Lymphoblastic Leukemia -- GRONINGER et al.
		Pharmacokinetics of Vincristine Monotherapy in Childhood Acute Lymphoblastic Leukemia
		Vincristine plasma concentration was measured by HPLC with electrochemical
	www.pedresearch.org /cgi/content/full/52/1/113 (3028 words)

	ADAP drugs: vincristine (Site not responding. Last check: 2007-10-08)
		Vincristine is given intravenously to treat KS and non-Hodgkinís lymphoma.
		Vincristine is used alone and in combination with other chemotherapies.
		Vincristine and vinblastine may be used in alternating weeks to reduce dose-limiting toxicity.
	www.atdn.org /access/drugs/vinc.html (336 words)

	Lilly: Vincristine Sulfate Injection
		The vincristine sulfate is embryotoxic and teratogenic in animals.
		There are individual case reports of normal and abnormal infants born to patients treated with vincristine sulfate alone and in combination with other drugs in the first trimester.
		Inhalation of a sufficient amount of vincristine powder or vincristine sulfate would be expected to cause local irritation of the nose and throat.
	www.ehs.lilly.com /msds/msds_vincristine_sulfate_injection.html (1717 words)

	Phase I Study of Liposomal Vincristine -- Gelmon et al. 17 (2): 697 -- Journal of Clinical Oncology
		with that of vincristine in that neurotoxicity was one of the
		free vincristine dosing was not as pronounced with ONCO-TCS.
		Owellen RJ, Owens AJ, Donigian DW: The binding of vincristine, vinblastine and colchicine to tubulin.
	www.jco.org /cgi/content/full/17/2/697 (4599 words)

	Vincristine (Site not responding. Last check: 2007-10-08)
		Vincristine is a drug used in the treatment of cancer.
		It interferes with the multiplication of cancer cells and slows or stops their growth and spread in the body.
		Vincristine can lower the number of white blood cells which guard against infections and platelets which prevent bleeding.
	www.bmi.net /mcaron/vincris.html (178 words)

	VINCRISTINE - INJECTION (Oncovin, Vincasar) side effects, medical uses, and drug interactions.
		Fatalities have occurred when vincristine was injected into the spine.
		USES: Vincristine is one of a large group of drugs known as "antineoplastics"; these drugs are also known as cancer drugs, chemotherapy, or "chemo".
		They are used in the treatment of various cancers to slow or stop the growth of cancer cells.
	www.medicinenet.com /vincristine-injection/article.htm (440 words)

	Sloan-Kettering - Vincristine
		Vincristine interferes with the ability of cancer cells to multiply and grow.
		A metallic taste in the mouth may occur while the drug is being given, but it is uncommon.
		The information is selective and does not cover all possible side effects; others may occur.
	www.mskcc.org /patient_education/html/47189.cfm (222 words)

	Liposomal and Nonliposomal Drug Pharmacokinetics after Administration of Liposome-Encapsulated Vincristine and Their ...
		free vincristine arising from liposomes in the circulation is
		AUC was calculated using the trapezoidal rule from 0 to 72 h after administration at a dose of 2 mg of vincristine/kg for the liposomal formulations and from 0 to 4 h for C-VINC.
		Horton JK, Houghton PJ and Houghton JA (1988) Relationships between tumor responsiveness, vincristine pharmacokinetics and arrest of mitosis in human tumor xenografts.
	jpet.aspetjournals.org /cgi/content/full/298/3/1206 (4317 words)

	Vincristine Alkaloid - Antineoplastic Breast Cancer Treatment Drug A-Z Breast Cancer Information and Support (Site not responding. Last check: 2007-10-08)
		: Vincristine, alone or in combination with other antineoplastic medications, is used for many types of cancer including leukemia, lymphoma, breast cancer, lung cancer, malignant melanoma, cancer of the uterine cervix, colorectal cancer, and Wilms' tumor.
		Vincristine may increase the amount of uric acid in the blood and the dosage on the other drugs that lower uric acid may need to be adjusted.
		Vincristine’s major side effects are hair loss, changes in the sense of taste and a reversible peripheral neuropathy which may cause numbness or tingling in toes and fingers.
	www.a-zbreastcancer.com /drugs/dVincristine.htm (348 words)

	Vincristine
		VINCRISTINE (Oncovin®) is a cancer chemotherapy agent used for treating many different types of cancer including acute
		Vincristine comes from a plant in the periwinkle family.
		When given with other chemotherapy agents, vincristine may increase the effects and/or side effects of the other chemotherapy.
	www.lafn.org /medical/po.bd.treatment.Vincristne.html (703 words)

	Vincristine (Site not responding. Last check: 2007-10-08)
		Older adults-Nervous system effects may be more likely to occur in the elderly, who are usually more sensitive to the effects of vincristine.
		Liver disease-Effects may be increased because of slower removal of vincristine from the body
		Dosing-The dose of vincristine will be different for different patients.
	thomas.communication-visuelle.net /treatment/vincristine.html (1406 words)

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