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Topic: Von Willebrand disease


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  Encyclopedia: Von Willebrand disease   (Site not responding. Last check: 2007-10-07)
It arises from a qualitative or quantitative deficiency of von Willebrand factor (vWF), a multimeric protein that is required for platelet adhesion.
Detection of vWD is complicated by vWF being an acute phase reactant with levels rising in infection, pregnancy and stress.
Type 3 is the most severe form of vWD (homozygous for the defective gene) and may have severe mucosal bleeding, no detectable vWF antigen, and may have sufficiently low factor VIII that they have occasional hemarthoses (joint bleeding), as in cases of mild hemophilia.
www.nationmaster.com /encyclopedia/Von-Willebrand-disease   (2122 words)

  
 Von Willebrand disease -- Facts, Info, and Encyclopedia article   (Site not responding. Last check: 2007-10-07)
Von Willebrand's disease (vWD) is the most common (Click link for more info and facts about hereditary) hereditary (The process of forming semisolid lumps in a liquid) coagulation abnormality described in humans.
Type 1 vWD (60-80% of all vWD cases) is a quantitative defect (heterozygous for the defective gene) but may not have clearly impaired (The process of forming semisolid lumps in a liquid) clotting, most patients usually end up leading a nearly normal life.
vWD is (Click link for more info and facts about named) named after Erik Adolf von Willebrand, a (The official language of Finland; belongs to the Baltic Finnic family of languages) Finnish (A specialist in the care of babies) pediatrician (1870-1949).
www.absoluteastronomy.com /encyclopedia/v/vo/von_willebrand_disease.htm   (994 words)

  
 October 1994 - von Willebrand Disease
Von Willebrand disease is caused by mutations in von Willebrand factor (VWF).
Von Willebrand disease was first termed 'pseudohemophilia', because it differed from hemophilia in its primarily mucosal (rather than joint and muscle) bleeding, the prolonged bleeding time (not found in hemophilia), and the fact that it affected females (hemophilia is X-linked and affects primarily males).
Von Willebrand factor is encoded by an autosomal gene on chromosome 12.
www.itxm.org /Archive/tmu10-94.htm   (1392 words)

  
 Dr. Koop - Von Willebrand's Disease- Health Encyclopedia and Reference
This is an inherited disorder characterized by abnormally slow coagulation of the blood and spontaneous epistaxis and gingival bleeding caused by a deficiency of a component of factor VIII.
Von Willebrand's disease is the most common inherited blood coagulation disorder, caused by a deficiency in a blood clotting factor known as Von Willebrand's factor.
Von Willebrand's disease affects both men and women alike (unlike hemophilia, which only leads to bleeding in men).
www.drkoop.com /encyclopedia/93/481.html   (588 words)

  
 Gale Encyclopedia of Medicine: Von Willebrand's disease
The disease was first described by the Finnish physician Erik von Willebrand in 1926, when he noticed that many members of a large family from the Aland Islands in the Gulf of Bothnia had a bleeding disorder with a distinct inherited pattern.
Von Willebrand's disease is passed from one generation to another in a well-defined pattern.
Von Willebrand's disease is characterized by having reduced vWF levels or by a nearly normal level of vWF that functions at reduced capacity.
www.findarticles.com /p/articles/mi_g2601/is_0014/ai_2601001468   (1012 words)

  
 MedlinePlus Medical Encyclopedia: Von Willebrand’s disease
Von Willebrand's disease is a hereditary bleeding disorder caused by a deficiency of von Willebrand factor.
Von Willebrand factor helps platelets to stick to the blood vessel wall and to each other, which is necessary for normal blood clotting.
Von Willebrand's disease is the most common hereditary bleeding disorder.
www.nlm.nih.gov /medlineplus/ency/article/000544.htm   (500 words)

  
 von Willebrand Disease
Von Willebrand disease, or vWD, is an inherited disorder that impacts the blood's ability to clot properly.
Von Willebrand disease is the most common inherited bleeding disorder, affecting as much as 1% of the population or more.
Pseudo, or platelet-type, von Willebrand disease is similar to Type 2B, but the defect is in the platelets instead of in the factor.
kidshealth.org /parent/medical/heart/vwd.html   (1072 words)

  
 von Willebrand Disease
von Willebrand disease was present in eight menorrhagia patients (6.6%) and in one control (0.8%) (P =.02); separate analyses by race revealed a von Willebrand disease prevalence of 15.9% among white and 1.4% among fl menorrhagia patients (P =.01).
Although a common symptom of von Willebrand disease is menorrhagia or metrorrhagia, the prevalence of this inherited bleeding disorder in women with heavy bleeding is not known.
VWD is a heterogeneous disorder, and patients are typed according to pathophysiology.
www.thedoctorsdoctor.com /diseases/vonwillebrands.htm   (7258 words)

  
 NHF | Bleeding Disorders Information Center | von Willebrand Disease
von Willebrand disease is a hereditary deficiency or abnormality of the von Willebrand factor in the blood, a protein that affects platelet function.
The disease is estimated to occur in 1% to 2% of the population.
Because the von Willebrand factor is the protein that carries factor VIII in the blood, the blood level of factor VIII may also be decreased.
www.hemophilia.org /bdi/bdi_types3.htm   (1517 words)

  
 Von Willebrand's Disease
Von Willebrand's disease is a bleeding disorder in which a protein in your body's blood system is missing or does not work well.
When the body does not produce von Willebrand factor, the cells (platelets) needed to form a clot do not work properly and clotting factor VIII levels are low, both of which can lead to severe bleeding.
Von Willebrand's disease causes symptoms similar to the bleeding disorder hemophilia.
www.peacehealth.org /kbase/topic/mini/hw183231/overview.htm   (532 words)

  
 UNDERSTANDING VON WILLEBRAND DISEASE   (Site not responding. Last check: 2007-10-07)
Canine von Willebrand's Disease (vWD) in Standard Poodles is an autosomal recessive genetic disease with a gene frequency estimated to be 15% of the Standard Poodles population.
Because it is an autosomal recessive disorder, Standard Poodles that are "Carriers" of the disease show no signs of vWD, yet can pass the gene along and perpetuate the disease through breeding.
In a single mutation, (with one mutated gene) a dog requires 1 normal and 1 mutated copy gene to be carrier and two mutated to have the full blown disease.
www.napoleon.org.uk /health/von_w.htm   (266 words)

  
 AHF - Von Willebrand Disease in Women
Von Willebrand disease (vWd) is characterized by the inability of the blood to clot normally.
If both parents are symptomatic for vWd, they have a 25% chance of having an affected child, a 50% chance of having a child who is a carrier, and 25% chance of having a child unaffected by vWd.
In rare cases, vWd is acquired during childbirth, drug-therapy, or autoimmune diseases such as rheumatoid arthritis, types of kidney failure, or certain cancers.
www.ahfinfo.com /ahfinfo/vonWillebrandinwomen.html   (1291 words)

  
 von Willebrand's Disease
Von Willebrand's disease is a bleeding disorder caused by a defect in a blood protein required for normal clotting and control of hemorrhage.
Cause...The bleeding tendency of vWD is caused by a deficiency of von Willebrand factor protein (vWF).
Dogs testing in the abnormal range are considered carriers of the vWD trait, and are at risk for transmitting an abnormal vWF gene to their offspring, and in some individuals for expressing an abnormal bleeding tendency.
www.angelfire.com /nc/meisenhaus/vwd.html   (692 words)

  
 von Willebrand's disease
Von Willebrand's disease (vWD) is a common, usually mild, inherited bleeding disorder in people and in dogs.
Dogs with vWD are prone to nose bleeds, bleeding from the gums, and prolonged bleeding during heat or after whelping.
Because the severity of bleeding with von Willebrand's disease is quite variable, often the disease is not diagnosed until the dog is 3 to 5 years old.
www.upei.ca /~cidd/Diseases/clinical%20pathology/von%20Willebrand%27s%20disease.htm   (1265 words)

  
 vW Disease   (Site not responding. Last check: 2007-10-07)
Von Willebrand disease (vWD) is not common within our breed, but it does occur, and has proved fatal to more than one Beardie.
In Dobermans 90% of dogs were carriers or affected with the disease at one time, by careful screening the occurrence has been reduced to less than 70%.
VWD is the most common of the three.
www.beaconforhealth.org /vwd.htm   (961 words)

  
 Von Willebrand Disease Causes Excessive Bleeding
One clotting factor is von Willebrand factor, and when this factor is mutated, you have von Willebrand disease.
Von Willebrand disease is most commonly transmitted from a parent to a child, and men and women have an equal chance of getting the mutated gene.
If your brother has von Willebrand disease, it is very likely one of your parents also had the disease, and then you would have about a 50% chance of also carrying the mutated gene.
healthlink.mcw.edu /article/1031002252.html   (332 words)

  
 OBGYN.net - von Willebrand Q and A
Because the most common symptoms of vWD in women (heavy and prolonged menstrual periods) are often misunderstood to be a gynecologic rather than a hematologic problem, the risk of misdiagnosis and undertreatment poses a greater health concern for women than it does for men.
When a person has a defect or deficiency in the clotting protein called von Willebrand factor, he or she has von Willebrand disease, which is an inherited disease.
An education initiative on vWD is the natural evolution of an expanding program that matches the growing body of knowledge of the disease.
www.obgyn.net /ENGLISH/PUBS/ANNOUNCEMENTS/VWD_Q_A.HTM   (1492 words)

  
 Von Willebrand disease definition - Medical Dictionary definitions of popular medical terms
Von Willebrand disease: An inherited bleeding disorder in which a clotting protein called von Willebrand factor is deficient or defective.
Von Willebrand factor is made by cells lining the wall of blood vessels.
In 1925 von Willebrand saw as a 5-year-old patient from the Ă…land Islands in the Sea of Bothnia between Finland and Sweden.
www.medterms.com /script/main/art.asp?articlekey=31159   (750 words)

  
 What Is von Willebrand Disease?
Von Willebrand disease is an inherited bleeding disorder.
Von Willebrand factor is one of those proteins.
Von Willebrand factor is also a carrier of clotting factor VIII, another protein that helps your blood to clot.
www.nhlbi.nih.gov /health/dci/Diseases/vWD/vWD_WhatIs.html   (351 words)

  
 Von Willebrand's Disease
Von Willebrand’s Disease is a genetic bleeding disorder.
The clinical signs of vWD are typical of a platelet function defect, such as spontaneous hemorrhage for mucosal surfaces, epistaxis, hematuria, melena and excessive hemorrhage from surgery or trauma.
Von Willebrand’s factor is a protein, the largest circulation protein in the body, and it is delicate.
www.geocities.com /schlosser44/vWD.html   (2998 words)

  
 Von Willebrand s Disease -- eCureMe.com
Von Willebrand's disease is a problem involving the body's ability to form blood clots.
Von Willebrand's disease is passed on from parent to child, affecting male and female alike.
Because this disease is inherited, all family members of patients with this disease should see their doctor and be evaluated for this condition.
www.ecureme.com /emyhealth/Pediatrics/Von_Willebrand_s_Disease.asp   (362 words)

  
 One Percent of Americans Have Von Willebrand Disease: What Is It?
Von Willebrand disease (VWD) is a hereditary bleeding disorder, in fact, one of the most common bleeding disorders known: it affects about 1% of all Americans.
People with von Willebrand disease don't have enough of the factor available in their blood, or the VWF that is present doesn't perform effectively.
Those who are diagnosed with von Willebrand disease might need special medication to control bleeding; they may also need more blood than usual in case of an accident, for dental work, or during surgery.
healthlink.mcw.edu /article/1030552013.html   (641 words)

  
 OBGYN.net - Bleeding Disorders in Women Fact Sheet   (Site not responding. Last check: 2007-10-07)
The most common bleeding disorder in women and girls is von Willebrand disease, an inherited disorder that affects up to 3% of the population, or approximately 2.6 million people.
von Willebrand disease was first recognized in 1925 by Erik von Willebrand, a Finnish physician, who described a new type of bleeding disorder in inhabitants of the Aland Islands.
von Willebrand disease is caused by a defect in or a deficiency of a blood clotting protein called von Willebrand factor.
www.obgyn.net /ENGLISH/PUBS/announcements/bleeding_in_women.htm   (342 words)

  
 Von Willebrand's disease
This disease, which is a deficiency in a certain clotting factor (a blood protein), can also be caused by other conditions such as hypothyroidism, estrus, pregnancy, infections and certain drugs including NSAIDs like aspirin.
vWD is the most common inherited bleeding disorder in dogs, and it is a recessive trait that can affect males and females equally.
These dogs lack the ability to manufacture von Willebrand's factor, or Factor VIII (8), a blood protein essential in the clotting cascade.
www.animalforum.com /dbreed/medvonwill.htm   (452 words)

  
 von Willebrand's Disease   (Site not responding. Last check: 2007-10-07)
von Willebrand's disease is a bleeding disorder found in many breeds of dog as well as other animals.
One of the primary distinctions of von Willebrand's disease however, is that this disorder is not sex-linked.
In its acquired presentation von Willebrand's is a complication of thyroid deficiency.
www.barkbytes.com /medical/med0036.htm   (269 words)

  
 eMedicine - Von Willebrand Disease : Article by John D Geil, MD   (Site not responding. Last check: 2007-10-07)
Background: Although referred to as a single disease, von Willebrand disease (vWD) is in fact a family of bleeding disorders caused by an abnormality of the von Willebrand factor (vWF).
Pathophysiology: vWD is due to an abnormality, either quantitative or qualitative, of the vWF, which is a large multimeric glycoprotein that functions as the carrier protein for factor VIII (FVIII).
In the homozygous patient, type 3 vWD is characterized by marked deficiencies of both vWF and FVIIIc in the plasma, the absence of vWF from both platelets and endothelial cells, and a lack of the secondary transfusion response and the response to DDAVP.
www.emedicine.com /ped/topic2419.htm   (3411 words)

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