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Topic: Von Willebrand factor

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	eMedicine - Von Willebrand Disease : Article by John D Geil, MD
		VWF activity (ristocetin cofactor): Ristocetin is an antibiotic that causes VWF to bind to and, subsequently, to activate platelets.
		The degree of platelet agglutination is proportional to the concentration of VWF in the plasma.
		Sadler JE: A revised classification of von Willebrand disease.
	www.emedicine.com /ped/topic2419.htm (3590 words)

	Von Willebrand's Disease
		Von Willebrand's factor is a glycoprotein produced both by platelets (the blood cells involved in clotting) and by the cells lining blood vessels.
		Von Willebrand's disease is not limited to the breeds listed here; forms of von Willebrand's disease have been found in over 50 breeds and in cats and humans as well.
		Von Willebrand's disease is usually detected when there is unexpected hemorrhage during a spay or neuter or when screening tests are done in anticipation of surgery on a member of a von Willebrand's breed.
	www.marvistavet.com /html/body_von_willebrand_s_disease.html (1066 words)

	[No title]
		Von Willebrand disease, or vWD, is an inherited disorder that affects the blood's ability to clot properly.
		Von Willebrand disease is the most common inherited bleeding disorder, affecting as much as 1% of the population or more.
		People with von Willebrand disease have a problem with the amount or quality of one or both of these blood components.
	www.utoronto.ca /kids/vWD.htm (842 words)

	CIGNA - Von Willebrand's Disease (Site not responding. Last check: )
		Von Willebrand's disease is a bleeding disorder in which a protein in your body's blood system is missing or does not work well.
		Von Willebrand's disease causes symptoms similar to the bleeding disorder hemophilia.
		Von Willebrand's disease is a lifelong disease, so you may need treatment at different times in your life.
	www.cigna.com /healthinfo/hw183231.html (0 words)

	October 1994 - von Willebrand Disease
		Von Willebrand disease is caused by mutations in von Willebrand factor (VWF).
		Von Willebrand disease was first termed 'pseudohemophilia', because it differed from hemophilia in its primarily mucosal (rather than joint and muscle) bleeding, the prolonged bleeding time (not found in hemophilia), and the fact that it affected females (hemophilia is X-linked and affects primarily males).
		Von Willebrand factor is encoded by an autosomal gene on chromosome 12.
	www.itxm.org /Archive/tmu10-94.htm (1392 words)

	VWF - von Willebrand factor
		Thrombotic thrombocytopenic purpura (TTP) is a life-threatening illness caused by deficiency of the vWF- cleaving protease ADAMTS13.
		This shear-induced platelet aggregation (SIPA) is mediated by von Willebrand factor binding to platelet membrane glycoprotein (GP) Ib and GPIIb/IIIa.
		The C2 domain of factor VIII (FVIII) mediates FVIII binding to von Willebrand factor (VWF) and phospholipids (PLs), thereby determining the stability and the activity of FVIII.
	www.ihop-net.org /UniPub/iHOP/gg/93078.html (4284 words)

	NHF \| Bleeding Disorders Information Center \| von Willebrand Disease
		von Willebrand disease is a hereditary deficiency or abnormality of the von Willebrand factor in the blood, a protein that affects platelet function.
		The disease is estimated to occur in 1% to 2% of the population.
		Because the von Willebrand factor is the protein that carries factor VIII in the blood, the blood level of factor VIII may also be decreased.
	www.hemophilia.org /bdi/bdi_types3.htm (1517 words)

	Factor VIII and von Willebrand factor (Site not responding. Last check: )
		Factor VIII is formed in the liver and blood vessels, and is present in the blood in various forms.
		The task of coagulation factor VIII is the acceleration of the activation of factor X. Functionally, it is therefore an accelerator protein.
		The counter-partner of factor VIII is protein C, which inactivates the active form of factor VIII circulating in the blood stream.
	www.biotest.de /ww/en/pub/folder_pharma/fields_of_use/haemophilia_a_und_b/haemostasis_and_blood_coagul/factor_viii_and_von_willebrand.htm (162 words)

	What is Von Willebrand Disease? \| Hemophilia Federation
		Von Willebrand Disease is caused by a defect on chromosome 12.
		In 1925, Dr. Erik von Willebrand of Helsinki published, in Finnish, his astute observations on a large family with a bleeding disorder from one of the Aland islands in the gulf between Sweden and Finland.
		Von Willebrand concluded that the disorder was due to “a disturbed function of the thrombocytes and a general lesion of the capillary walls “and called it “pseudohemophilia”.
	www.hfindia.org /node/49 (2370 words)

	von Willebrand Factor
		Synonyms Multimer Assay; Ristocetin Cofactor; Ristocetin-Induced Platelet Aggregation Assay; von Willebrand Factor Antigen; von Willebrand Factor Assay; von Willebrand Factor Collagen-Binding Assay; von Willebrand Factor Multimer Assay
		Sadler JE, "A Revised Classification of von Willebrand Diseases,"Thromb Haemost, 1994, 71:520-5.
		Tsai HM and Lian EC, "Antibodies to von Willebrand Factor-Cleaving Protease in Acute Thrombotic Thrombocytopenic Purpura,"N Engl J Med, 1998, 339(22):1585-94.
	www.massgeneral.org /pathology/coagbook/CO006200.htm (2457 words)

	von Willebrand Factor (vWF) - Haematologic Technologies
		Von Willebrand factor (vWF) is a multimeric plasma glycoprotein that is required for normal hemostatic platelet plug formation (1-8).
		During normal hemostasis, the larger multimers of vWF are responsible for facilitating platelet plug formation by forming a bridge between platelet glycoprotein IB and exposed collagen in the subendothelium (9-14).
		Either a lack of vWF protein or the presence of abnormalities which result in decreased polymerization may cause a loss of biological activity which is characteristic of von Willebrand's disease.
	www.haemtech.com /Cofactors/vWF.htm (507 words)

	Bibliografia - Tesi - Malattia di von Willebrand: Espressione in vitro di varianti molecolari di tipo 2B e valutazione ...
		Propolypeptide of von Willebrand factor circulates in blood and is identical to von Willebrand antigen II.
		The binding domain of von Willebrand factor to sulfatides is distinct from those interacting with glycoprotein Ib, heparin, and collagen and resides between amino acid residues Leu 512 and Lys 673.
		Abnormalities of factor VIII and platelet aggregation - use of ristocetin in diagnosing the von Willebrand syndrome.
	www.tesionline.it /consult/bibliografia.jsp?idt=9740 (3414 words)

	Von Willebrand disease - MayoClinic.com
		Treatment of von Willebrand disease focuses on stopping or preventing bleeding episodes, typically by using medications that increase the levels and activity of von Willebrand clotting factor and related substances in your blood.
		Von Willebrand disease affects males and females in approximately equal proportions and is present in up to 1 percent of the U.S. population.
		Von Willebrand disease was first identified in the 1920s by Erik Adolf von Willebrand, a Finnish doctor.
	www.mayoclinic.com /health/von-willebrand-disease/DS00903/METHOD=displayFull (246 words)

	von Willebrand Disease
		Von Willebrand disease, or vWD, is an inherited disorder that impacts the blood's ability to clot properly.
		Von Willebrand disease is the most common inherited bleeding disorder, affecting as much as 1% of the population or more.
		Pseudo, or platelet-type, von Willebrand disease is similar to Type 2B, but the defect is in the platelets instead of in the factor.
	kidshealth.org /parent/medical/heart/vwd.html (1092 words)

	MedlinePlus Medical Encyclopedia: Von Willebrand disease
		Von Willebrand disease is the most common hereditary bleeding disorder.
		Von Willebrand disease is caused by a deficiency of von Willebrand factor.
		Von Willebrand factor helps platelets to clump together and stick to the blood vessel wall, which is necessary for normal blood clotting.
	www.nlm.nih.gov /medlineplus/ency/article/000544.htm (535 words)

	von Willebrand Disease
		Von Willebrand disease is the most common inherited bleeding disorder, affecting about 1% to 2% of people.
		People with von Willebrand disease have bleeding problems because the levels or function of these blood components needed for clotting are abnormal.
		The most common treatment used for type 1 von Willebrand disease is the drug desmopressin, which causes a temporary increase in the von Willebrand factor level.
	www.kidshealth.org /PageManager.jsp?dn=firststudenthealthzone&ps=604&article_set=34943&cat_id=20361&lic=201 (918 words)

	Factor VIII
		Factor VIII werkt samen met de Von Willebrand factor.
		De Von Willebrand factor is een speciaal eiwit dat tijdens het stollingsproces een lijmfunctie vervult.
		Hoe lager het gehalte van factor VIII of de Von Willebrand factor is hoe ernstiger de ziekte is. Bij ernstige vormen kunnen zelfs bloedingen optreden in gewrichten, spieren, en zacht weefsel.
	www.factorvleiden.nl /text/f1118de-20.html (444 words)

	Von Willebrand's Disease-Treatment Overview
		Treatment for all types of von Willebrand's disease consists of medications to increase the von Willebrand factor in your blood and to prevent the breakdown of blood clots.
		Desmopressin medication, to help increase the production of von Willebrand factor, to lessen the blood loss for women during their menstrual periods, and to help control bleeding episodes.
		Estrogen therapy is also used sometimes to treat women with von Willebrand's disease who have heavy periods, especially if they are undergoing surgery.
	www.webmd.com /a-to-z-guides/Von-Willebrands-Disease-Treatment-Overview (0 words)

	Von Willebrand Disease: Treatment
		Factor VIII Concentrate with Von Willebrand Factor is made from pooled human plasma.
		The plasma used for Factor VIII Concentrate with Von Willebrand Factor is screened for blood-borne viruses such as HIV and Hepatitis B and C. Any plasma found to contain these viruses is not used.
		Factor VIII Concentrate with Von Willebrand Factor is injected into a vein.
	www.hemophilia.ca /en/2.2.6.php (972 words)

	von Willebrand Factor (vWF) Gene Analysis
		von Willebrand’s disease (vWD) is the most common inherited bleeding disorder with a prevalence as high as 1 to 2 percent in the general population.
		The disease is caused by an inherited defect in the von Willebrand factor (vWF), a large multimeric glycoprotein, with essential roles in primary homeostasis and as a carrier of coagulation factor VIII (FVIII) in the circulation.
		About 60% of the variation in vWF plasma is due to genetic factors, although a definitive diagnosis is complicated by ABO blood type, ethnic background, reduced penetrance and variable expressivity.
	www.cityofhope.org /cmdl/vWD.asp (300 words)

	What Is von Willebrand Disease?
		Von Willebrand disease (VWD) is an inherited bleeding disorder.
		Von Willebrand factor acts like glue to help the platelets stick together and form a blood clot.
		Factor VIII is the protein that's inactive or missing in hemophilia, another clotting disorder.
	www.nhlbi.nih.gov /health/dci/Diseases/vWD/vWD_WhatIs.html (422 words)

	Learn More about von Willebrand Disease
		Von Willebrand factor is what allows the platelets to stick to the blood vessel wall.
		While von Willebrand disease is considered to be hereditary (the gene is passed from one generation to another), it can also occur in someone who has no family history of the disorder.
		Testing for von Willebrand disease is done at hemophilia treatment centers such as the New England Hemophilia Center at UMass Memorial Medical Center, Memorial Campus.
	www.umassmemorial.org /ummhc/hospitals/med_center/services/bleeding-clotting-disorders/vonwillebrand.cfm (388 words)

	About Von Willebrand
		von Willebrand Disease is an inherited deficiency or defect of a blood clotting substance called von Willebrand factor.
		Unlike hemophilia, von Willebrand Disease occurs equally amongst males and females and is much more common than hemophilia, occurring in 1 in every 50 births.
		Estrogen, usually in the form of birth control pills, helps to raise the level on von Willebrand Factor in the body and are very useful for heavy menstrual bleeding.
	www.hemophilianevada.org /id18.html (431 words)

	Divergent Fates of Von Willebrand Factor and Its Propolypeptide (Von Willebrand Antigen II) after Secretion from ...
		The intracellular site of cleavage of pro-von Willebrand factor subunit and the subsequent fate of the propolypeptide (von Willebrand antigen II) and of the mature von Willebrand factor (vWf) were investigated.
		This indicates that vWf and the propolypeptide were packaged into the Weibel--Palade bodies as one unit, pro-vWf, and that the proteolytic cleavage of pro-vWf is likely to be a post-Golgi event.
		The propolypeptide did not associate with vWf in the culture medium, did not codistribute with vWf in the extracellular ``patches of release'' on stimulated endothelial cells, and was not detected in the endothelial cell extracellular matrix, which did contain vWf.
	www.pnas.org /cgi/content/short/84/7/1955 (661 words)

	Project Red Flag > More Information on Von Willebrand's Disease
		A parent with von Willebrand disease has a 50% chance of passing the disease to each of his or her children, male or female.
		VWF is composed of small chains that combine to form larger chains called multimers that help the blood to clot.
		VWF has two functions in the clotting process: 1) acting as a bridge between platelets and a site of injury so that blood can clot in the right place and 2) to protect factor VIII, an essential protein in blood clotting.
	www.projectredflag.org /common_questions/more_von_willebrand.htm (332 words)

	Human blood platelet adhesion to artery subendothelium is mediated by factor VIII−Von Willebrand factor bound to ...
		Human blood platelet adhesion to artery subendothelium is mediated by factor VIII−Von Willebrand factor bound to the subendothelium
		This plasma factor, then named Von Willebrand factor, was later identified as factor VIII (anti-haemophilic factor A (ref. 3)).
		The current concept is that Von Willebrand factor and factor VIII are present in a complex, which can be dissociated in certain conditions.
	www.nature.com /nature/journal/v279/n5714/abs/279636a0.html (422 words)

	von Willebrand Factor (vWF) Activity
		vWF levels are increased two- to threefold in the second and third trimesters of pregnancy.
		In this ristocetin cofactor assay, the patient plasma is mixed with formalin-fixed platelets in the presence of ristocetin.
		The extent of platelet agglutination detected photo-optically is proportional to the vWF activity of the sample.
	www.labcorp.com /datasets/labcorp/html/chapter/mono/cf001600.htm (653 words)

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