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| | Acid-Base Tutorial - Strong Ion Difference |
 | | At the molecular level, it is clearly the concentration of CO, not the partial pressure, which governs its effect on other molecules and ions. |
 | | By contrast, if the body accumulates one of the organic acids, e.g., lactate, formate, keto-acids, then the metabolic acidosis is characterized by a normal chloride concentration and an abnormal anion gap because of the presence of the "unmeasured" organic acid. |
 | | Making the greatest contribution to acid-base balance are the proteins, particularly albumin, which behave collectively as a weak acid. |
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