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	Werner syndrome - Wikipedia, the free encyclopedia
		For this reason, Werner syndrome is often referred to as a progeroid syndrome, as it partly mimics the symptoms of Progeria.
		Werner syndrome is estimated to affect 1 in 200,000 individuals in the United States.
		Werner syndrome is named after Otto Werner, a German student who described the syndrome as part of his doctoral thesis in 1904.
	en.wikipedia.org /wiki/Werner_syndrome (604 words)

	Werner syndrome definition - Medical Dictionary definitions of popular medical terms
		The characteristic features of Werner syndrome include short stature, premature graying and balding, wizened face, beaked nose, cataracts, scleroderma-like skin changes (especially in the extremities), subcutaneous calcification (deposits of calcium beneath the skin), premature arteriosclerosis, muscular atrophy and tendencies to diabetes mellitus and to tumors (especially, osteosarcoma and meningioma).
		The gene for Werner syndrome, symbolized WRN, is on chromosome 8 (in the region of bands 8p12-p11.2.
		Werner syndrome has nothing whatsoever to do with Werner-His disease which is a louse-borne illness first recognized in the trenches of World War I and so named trench fever.
	www.medterms.com /script/main/art.asp?articlekey=16235 (365 words)

	Werner syndrome Information on Healthline
		Werner syndrome is a very rare, inherited disease that resembles premature aging.
		Werner was a medical student in 1903 when he first observed the syndrome in four siblings, all about 30 years of age.
		For instance, the tumors commonly seen in Werner syndrome patients are commonly derived from the cells of the mesoderm, a middle layer of the embryo that gives rise to a variety of tissues including cartilage, muscle, bone, kidneys, and connective tissue.
	www.healthline.com /galecontent/werner-syndrome (1134 words)

	Progeria Information Database: Werner's Syndrome Symptoms (Site not responding. Last check: 2007-10-09)
		Concentrated primarily in the Japanese population for reasons as yet unknown, Werner’s syndrome (WS) is the most common of all recognized progeroid syndromes.
		Werner is sometimes also called "adult onset progeria," because unlike most progeroid syndromes it manifests only after the onset of puberty.
		In the case of Werner’s syndrome, these include but are not limited to hair graying and loss, the appearance of heavy skin wrinkles, muscle atrophy, osteoporosis, cataracts in the eyes, discontinued function of the reproductive organs, arteriosclerosis, and the onset of diabetes mellitus II.
	instruct1.cit.cornell.edu /Courses/bionb420ageless/student2005/ljh34/werner.htm (380 words)

	Werner syndrome
		Werner syndrome is a premature aging disease that begins in adolescence or early adulthood and results in the appearance of old age by 30-40 years of age.
		The gene for Werner disease (WRN) was mapped to chromosome 8 and cloned: by comparing its sequence to existing sequences in GenBank, it is a predicted helicase belonging to the RecQ family.
		The molecular role of WRN in Werner syndrome therefore remains to be proven, as does any role it might have in the aging process in general.
	www.ncbi.nlm.nih.gov /books/bv.fcgi?call=bv.View..ShowSection&rid=gnd.section.188 (238 words)

	Werner's Syndrome Gene Cloned! (Site not responding. Last check: 2007-10-09)
		Werner's syndrome(WS) is an inherited disease that has symptoms that resemble premature aging.
		The gene associated with Werner's syndrome appears to be a DNA helicase.
		The cloning of the Werner's syndrome gene is significant in that it indicates that a single gene can have a large effect upon the aging process.
	www.immortality.org /werners.html (429 words)

	Werner syndrome: Facts and details from Encyclopedia Topic (Site not responding. Last check: 2007-10-09)
		Werner syndrome is an exceedingly rare disorder, EHandler: no quick summary.
		Tar syndrome (thrombocytopenia and absent radius) is a rare genetic disorder which is characterised by the absence of the radius bone in the forearm, EHandler: no quick summary.
		Occipital horn syndrome is a variant of ehlers danlos syndrome....
	www.absoluteastronomy.com /encyclopedia/w/we/werner_syndrome.htm (1143 words)

	International Registry of Werner Syndrome / Home
		The International Registry of Werner Syndrome provides a central repository for data and materials in order to advance the progress of research and education relevant to this disorder.
		Werner Syndrome was first described by Dr. Otto Werner at the Kiel University in 1904 (Werner, 1904).
		The average age of clinical diagnosis of this syndrome is in the late thirties, and death usually occurs before the age of 55.
	www.wernersyndrome.org /registry/registry.html (550 words)

	Werner syndrome - Genetics Home Reference
		Werner syndrome is a rare disorder characterized by the dramatic, rapid appearance of aging.
		As the syndrome progresses, affected people may experience additional skin problems, type 2 diabetes, diminished fertility, severe hardening of the arteries (arteriosclerosis), thinning bones (osteoporosis), and some types of cancer.
		Mutations in the WRN gene cause Werner syndrome.
	ghr.nlm.nih.gov /condition=wernersyndrome (758 words)

	Werner Syndrome
		Werner Syndrome is a premature aging disease that begins in adolescence or early adulthood and results in the appearance of old age by 30 - 40 years of age...
		The gene for Werner disease (WRN) was mapped to chromosome 8 and cloned...
		The features of Werner syndrome are scleroderma - like skin changes, especially in the extremities, cataract, subcutaneous calcification, premature arteriosclerosis, diabetes mellitus, and a wizened and prematurely aged facies...
	ibis-birthdefects.org /start/werner.htm (534 words)

	Werner's syndrome helicase WRN antibody (ab200) datasheet (Site not responding. Last check: 2007-10-09)
		The Werner's syndrome helicase (WRN) gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases.
		Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.
		Werner's syndrome protein is phosphorylated in an ATR/ATM-dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycle.
	www.abcam.com /?datasheet=200 (624 words)

	Scientists Identify Genetic Link Between Cancer and Aging
		Werner syndrome is a rare genetic disorder that develops when the WRN gene is missing or defective.
		The syndrome is thought to occur because mutations in WRN cause genetic instability, a condition in which chromosomes are dramatically rearranged.
		In cells in which the Werner syndrome gene was missing, an overabundance of Myc caused the cells to rapidly age.
	www.fhcrc.org /about/ne/news/2003/06/27/aging.html?&&printfriendly=yes (755 words)

	A syndrome Of Premature Senility
		Werner’s syndrome (WS), or adult progeria, is a rare autosomal recessive disease that presents with symptoms and signs of premature aging.
		The diagnosis of Werner's syndrome is not usually made until the patients are in their thirties.
		The usual cause of death in Werner's syndrome is cardiac or cerebrovascular disease.
	www.kfshrc.edu.sa /annals/166/95-255.html (1233 words)

	Werner Syndrome
		Werner's patients physical characteristics are usually short with a stocky trunk.
		It is on of the many types of diseases and disorders that develop with Werner because of the premature ageing.
		Thyroid carcinoma is an unuasal cancer that may develop in people who have Werner Syndrome.
	www.rlc.dcccd.edu /MATHSCI/reynolds/progeria/Werner/werner_syndrome.htm (548 words)

	Werner Syndrome
		Werner Syndrome is a rare progressive disorder that is characterized by the appearance of unusually accelerated aging (progeria).
		Children with Werner Syndrome have an abnormally slow growth rate, and there is cessation of growth at puberty.
		Werner Syndrome is inherited as an autosomal recessive trait.
	www.bchealthguide.org /kbase/nord/nord135.htm (547 words)

	Fight Aging!: More on Werner's Syndrome - Gene Expression Profiles
		It seems that gene expression changes due to Werner's syndrome closely resemble those accompanying normal aging: Werner syndrome (WS) is a premature aging disorder, displaying defects in DNA replication, recombination, repair, and transcription.
		Since I mentioned research into Werner's syndrome (a rare condition causing accelerated aging, or at least the appearance and consequences of accelerated aging) a couple of days ago, some interesting further work was drawn to my attention.
		Werner syndrome (WS) is a premature aging disorder, displaying defects in DNA replication, recombination, repair, and transcription.
	www.fightaging.org /archives/000329.php (620 words)

	Richland College, Biol. 2402 - Introduction to Progeria
		Werner syndrome is commonly referred to as "progeria of the adult." It was first described in 1904 by general practitioner Otto Werner.
		Werner syndrome is more common with estimated cases between 1 in 100,000 and 1 in 1,000,000.
		Werner's appears at the onset of puberty and the average life span is 20-30 years.
	www.nasbite.dcccd.edu /MATHSCI/reynolds/progeria/intro/progeria1.htm (472 words)

	Age related expression of Werner's syndrome protein in selected tissues and coexpression of transcription factors -- ...
		Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced apoptosis in S-phase.
		Werner syndrome: proliferation in vitro of clones of cells bearing chromosome translocations.
		Werner's syndrome associated with progressive subcortical vascular encephalopathy of the Binswanger type [in Japanese].
	jcp.bmjjournals.com /cgi/content/full/55/3/195 (2480 words)

	Journal of Orthopaedic Surgery: A report of two cases of Werner's syndrome and review of the literature (Site not responding. Last check: 2007-10-09)
		At the age of 53 years, Werner's syndrome was diagnosed, along with a malignant soft tissue tumour of the hand.
		The incidence of Werner's syndrome in Japan is extremely high (about 1000 of the around 1300 cases reported worldwide) compared to other countries.
		Therefore, early recognition of Werner's syndrome is important to assist identification of malignant tumours at an early stage in this patient group.
	www.findarticles.com /p/articles/mi_qa3794/is_200312/ai_n9339509 (398 words)

	Positional Cloning of the Werner's Syndrome Gene -- Yu et al. 272 (5259): 258 -- Science
		Werner's syndrome (WS) is an inherited disease with clinical symptoms resembling premature aging.
		A Werner syndrome protein homolog affects C. elegans development, growth rate, life span and sensitivity to DNA damage by acting at a DNA damage checkpoint.
		Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process..
	www.sciencemag.org /cgi/content/short/272/5259/258 (2796 words)

	Werner Syndrome Protein Phosphorylation by Abl Tyrosine Kinase Regulates Its Activity and Distribution -- Cheng et al. ...
		The Werner syndrome protein is a DNA helicase.
		Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation.
		Werner syndrome diploid fibroblasts are sensitive to 4-nitroquinoline-N-oxide and 8-methoxypsoralen: implications for the disease phenotype.
	mcb.asm.org /cgi/content/full/23/18/6385 (6459 words)

	Werner Syndrome
		Werner Syndrome is a disease which hastens the aging process.
		Werner Syndrome is very uncommon, as it is chromosomal recessive.
		Helicase, an enzyme whose coding is found on the WRN locus on the eighth chromosome, unwinds DNA and RNA during mitosis, is involved with the mutations leading to Werner Syndrome.
	cristae.4t.com /Werner_Syndrome.html (202 words)

	Werner’s syndrome - Patient UK
		It is thought that the features associated with Werner’s syndrome occur as a result of abnormal metabolism in connective tissue, and that immunological abnormalities such as a decrease in the T cell sub-populations are responsible for the increased frequency in malignancies.
		There is no specific treatment available for Werner’s syndrome, although surgical intervention and hyperbaric oxygen therapy may be of use in the treatment of refractory skin ulcers.
		Prevention The genes associated with Werner’s syndrome have been isolated and identified, and pre-natal screening might be made available to parents who are considered at high risk of having an affected child.
	www.patient.co.uk /showdoc/40001442 (483 words)

	Science & Technology at Scientific American.com: Ask the Experts: Medicine: What do we know about the cause of ... (Site not responding. Last check: 2007-10-09)
		For example, Werner syndrome patients develop neoplasms prematurely, but the neoplasms tend to be those derived from mesenchymal rather than epithelial cells; the latter are the main source of tumors of older people.
		Werner patients suffer from osteoporosis, but the distribution is unusual in that it is very severe in the long bones of the legs.
		Patients who have Hutchinson-Gilford syndrome experience arthritis of the hips, but it is a result of having been born with dislocated hips.
	www.sciam.com /askexpert_question.cfm?articleID=0001E847-B16E-1C71-9EB7809EC588F2D7&catID=3&topicID=12 (561 words)

	Homologous Recombination Resolution Defect in Werner Syndrome -- Saintigny et al. 22 (20): 6971 -- Molecular and ...
		Werner syndrome (WRN) is an uncommon autosomal recessive disease
		Biochemical and Kinetic Characterization of the DNA Helicase and Exonuclease Activities of Werner Syndrome Protein.
		Inhibition of Werner Syndrome Helicase Activity by Benzo[c]phenanthrene Diol Epoxide dA Adducts in DNA Is Both Strand-and Stereoisomer-dependent.
	mcb.asm.org /cgi/content/abstract/22/20/6971 (1177 words)

	Werner's Syndrome Protein Is Required for Correct Recovery after Replication Arrest and DNA Damage Induced in S-Phase ...
		Werner's Syndrome Protein Is Required for Correct Recovery after Replication Arrest and DNA Damage Induced in S-Phase of Cell Cycle -- Pichierri et al.
		Werner's Syndrome Protein Is Required for Correct Recovery after Replication Arrest and DNA Damage Induced in S-Phase of Cell Cycle
		Werner's syndrome (WS) is a rare autosomal recessive disorder that arises as a consequence of mutations in a gene coding for
	www.molbiolcell.org /cgi/content/abstract/12/8/2412 (858 words)

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