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| | Neuroscience-Net-Pharmacology Section (Site not responding. Last check: 2007-09-04) |
 | | The substituted benzamide YM 09151-2 (cis-N-(1-benzyl-2-methylpyrrolidine-3-yl)-5-chloro-2- methoxy-4-methylaminobenzamide; emonapride) is a D2-like (D2, D3, and D4) dopamine receptor antagonist (Seeman and Van Tol, 1994; Terai, et al., 1989; Madras, et al., 1988). |
 | | Another and as yet unexplored potential target for YM 09151-2 binding is the 5-HT4 receptor, which is present in moderate density in striatal and limbic brain regions (Jakeman, et al., 1994; Waeber, et al., 1993). |
 | | From a molecular standpoint, YM 09151-2 is a close congener of 4-amino-5-chloro-2-methoxy-substituted benzamide compounds including cisapride, zacopride, and renzapride, which are agonists at hippocampal serotonin 5-HT4 receptors (Bockaert, et al., 1990; Chaput, et al., 1990). |
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