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Topic: Zeatin

In the News (Wed 30 Dec 09)

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Penelope Cruz

Mickey Rourke

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Hugh Jackman

	Mycorrhiza Literature Exchange
		Stomatal gas exchange and zeatin riboside levels (as determined by ELISA) of flax (Linum usitatissimum L.) were investigated with regard to an observed growth response of these plants to vesicular-arbuscular mycorrhizal infection, which was shown not to be related to increased nitrogeen, phosphorus or potassimum contents of plants.
		During the beginning of the mycorrhizal infection zeatin riboside levels in roots were temporarely decreased when compared to non-mycorrhizal plants, whereas levels where increased in shoots.
		Zeatin applied alone into the vascular system of non-mycorrhizal flax did not affect stomatal gas exchange, whereas abscisic acid applied alone decreased transpiration and CO assimilation rates.
	mycorrhiza.ag.utk.edu /H2O/vadrug1.htm (302 words)

	Senetek PLC Announces Successful Completion of Zeatin Pre-Clinical Studies; Clinical Trials Underway
		Among the in vitro pre-clinicals was a study of the effects of two concentrations of Zeatin on cultured human fibroblasts over their 300 day lifespan in laboratory culture, conducted at the University of Aarhus, Denmark, which concluded that Zeatin promotes maintenance of small cell size, cell structural and functional integrity, key determinants of youthful-looking skin.
		Zeatin was also found to prevent the accumulation of macromolecular debris in cells and increases the activity of the antioxidant enzymes catalase and glutathione peroxidase to counter free radicals, suggesting Zeatin is a powerful antioxidant.
		Senetek's patented compounds Kinetin and Zeatin are naturally occurring cytokinins that have proven effective in improving the appearance of aging skin with virtually none of the side effects associated with acid-based active ingredients.
	www.prnewswire.com /cgi-bin/stories.pl?ACCT=104&STORY=/www/story/04-26-2005/0003486203&EDATE= (767 words)

	[No title]
		Bassil, N.V., Mok, D.W.S., Mok, M.C. Isolation and characterization of a cis-trans isomerase of zeatin.
		Zeatin 1 mM Staureosporin 1 \'b5M \par 6.
		Zeatin 1 mM Staureosporin 1 \'b5M 0.0046 \par 6.
	www.siu.edu /~pbgc/classes/crcpress.doc (10020 words)

	Chen et al.
		Auxin-induced rooting was inhibited by kinetin, zeatin, 6- methylpurine, cyloheximide and the intercalating chemicals, ethidium bromide, acridine orange, ellipticine and proflavine at 10 to 100 µM. Kinetics of the inhibition indicated that 6-methylpurine, ethidium bromide and zeatin act similarly while cycloheximide inhibition is somewhat different.
		The kinetics of zeatin and EB inhibition was also compared to the former compounds, since little is known about the action of zeatin and EB as inhibitors of root growth.
		The interaction of EB and zeatin with NAA presumably involving a hypothetical receptor as a function of the rooting response was superficially evaluated on the basis of inhibition reversal by increasing concentrations of NAA.
	www.epress.com /w3jbio/vol1/chen/chen.html (3457 words)

	Mycorrhiza Literature Exchange
		Stomatal gas exchange and zeatin riboside levels (as determined by ELISA) of flax (Linum usitatissimum L.) were investigated with regard to an observed growth response of these plants to vesicular-arbuscular mycorrhizal infection, which was shown not to be related to increased nitrogen, phosphorus or potassimum contents of plants.
		Zeatin applied alone into the vascular system of non-mycorrhizal flax did not affect stomatal gas exchange, whereas abscisic acid applied alone decreased transpiration and CO2 assimilation rates.
		Additional application of zeatin, however, partially reversed abscisic acid-mediated effects and improved transpiration and CO2 assimilation rates showing analogy to the mycorrhizal infection.
	mycorrhiza.ag.utk.edu /latest/1993/93_druge1.htm (290 words)

	Cytokinins
		Though it is a natural compound, It is not made in plants, and is therefore usually considered a "synthetic" cytokinin (meaning that the hormone is synthesized somewhere other than in a plant).
		The most common form of naturally occurring cytokinin in plants today is called zeatin which was isolated from corn (Zea mays).
		Almost simultaneous with Miller Letham published a report on zeatin as a factor inducing cell division and later described its chemical properties (Letham, 1963).
	www.plant-hormones.info /cytokinins.htm (627 words)

	Senetek PLC Announces Uniformly Positive Results for its Long-Term Study of Zeatin; Plans Launch of Pre-Clinical Testing
		The new results were consistent with earlier studies of Zeatin and Senetek's lead anti-aging compound Kinetin which suggested that at higher concentrations Zeatin was more effective than Kinetin in certain measures of bioactivity.
		The new study shows that Zeatin does not interfere with the genetic control of cellular lifespan in early passage (young) or late passage (old) cells, that Zeatin promotes maintenance of small cell size (a key determinant of youthful skin) and structural and functional integrity, and that Zeatin prevents accumulation of macromolecular damage in the cell.
		The study further found that Zeatin increases the activity of the antioxidant enzymes catalase and glutathione peroxidase, to counteract free radical-induced oxidative damage during cell aging, and that Zeatin-treated cells are more resistant to ethanol- and hydrogen peroxide-induced cell death, suggesting enhanced stress tolerance of the treated cells.
	www.prnewswire.com /cgi-bin/stories.pl?ACCT=104&STORY=/www/story/03-10-2004/0002125495&EDATE= (540 words)

	Fountain of Youth (One-Day Wonder) \| SmartMoney.com
		Like Kinetin, Zeatin is based on a naturally occurring organic compound found in plants that inhibits aging.
		Zeatin has yet to be tested on humans, but that's not necessarily bad for the product's prospects.
		Since Zeatin is what the industry calls a cosmeceutical, a cosmetic product offering healthy properties, it doesn't need to go through years of human trials or gain approval from the Food and Drug Administration.
	www.smartmoney.com /onedaywonder/index.cfm?story=20040310 (991 words)

	Partnership for Plant Genomics Education - Plant Transformation page 7 (Site not responding. Last check: 2007-10-30)
		The antibiotics and zeatin riboside, are heat sensitive and are filter sterilized, then added to the media after the media has been sterilized by autoclaving.
		The MSZ plates (MS plates containing zeatin riboside) are poured and allowed to solidify and dry overnight.
		The zeatin riboside stimulates the transformed cells to regenerate.
	ceprap.ucdavis.edu /Transformation/e0120c7f (102 words)

	AUER, CAROL A., A. ESTER SZTEIN, ANDERS OSTIN, AND GORAN SANDBERG. (Site not responding. Last check: 2007-10-30)*
		Previous research suggested that green algae, mosses, ferns and horsetails contain isopentenyl adenine, zeatin and the riboside and ribotide conjugates; gymnosperms and angiosperms contained a more complex group of cytokinins, including dihydrozeatin (DHZ), N-glucoside and O-glucoside conjugates (Auer, 1997, Pl Growth Regul 23:17-32).
		We are examining the endogenous cytokinins in five lower plants in the Bryophyta and Tracheophyta: Pallavicinia lyellii (liverwort), Funaria hygrometrica (moss), Sphagnum angustifolium (moss), Selaginella kraussiana (club moss) and Nephrolepis exaltata (fern).
		In Nephrolepis fern sporophyte tissue, isopentenyl adenosine, zeatin riboside and zeatin-O-glucoside were identified; no DHZ or N-glucoside conjugates could be detected.
	www.ou.edu /cas/botany-micro/bsa-abst/section10/abstracts/10.shtml (288 words)

	Senetek - Press Release January 5, 2005
		This study model is designed to evaluate new compounds for safety and efficacy in the potential treatment of skin anti-aging and to investigate the mechanisms by which they affect the skin aging process.
		The study evaluated three groups of mice that received daily applications of Zeatin, AK801 and PRK124, respectively, versus a "placebo control" group that received applications of only the topical vehicle and a "therapeutic control" group that received topical tretinoin 0.05%, tradename Renova®, the only prescription drug approved for anti-aging in the United States.
		In addition, an absence of thickening of the dermis and epidermis was equivalent to the "placebo control" group over the three week treatment period indicating the skin tolerance of these new compounds.
	www.senetekplc.net /SENETEK/Jan5_2005.html (631 words)

	David Mok \| Center for Genome Research and Biocomputing
		The long-term goal of the project is to identify and characterize genes important to cytokinin biology.
		The project is focused on the metabolism of zeatin, the most prevalent naturally occurring cytokinin.
		In addition, we are in the process of cloning genes encoding zeatin reductase and isomerase.
	www.cgrb.orst.edu /faculty/mokd (258 words)

	Plant Physiology Online: (Site not responding. Last check: 2007-10-30)
		Cultured tobacco callus was transferred to fresh medium that contained an auxin and either zeatin or kinetin at the indicated concentrations.
		The results show that zeatin is more effective than kinetin in supporting tobacco tissue growth.
		M zeatin, and higher zeatin concentrations either did not stimulate additional growth or were slightly inhibitory.
	www.plantphys.net /image.php?id=262 (103 words)

	A Gene Encoding the Cytokinin Enzyme Zeatin O-Xylosyltransferase of Phaseolus vulgaris -- Martin et al. 120 (2): 553 -- ...
		A Gene Encoding the Cytokinin Enzyme Zeatin O-Xylosyltransferase of Phaseolus vulgaris -- Martin et al.
		Zeatin is the most active and ubiquitous form of the naturally occurring cytokinins.
		Martin RC, Martin RR, Mok MC, Mok DWS (1990) A monoclonal antibody specific to zeatin O-glycosyltransferases of Phaseolus.
	www.plantphysiol.org /cgi/content/full/120/2/553 (2662 words)

	ARS \| Publication request: Transgenic Maize with Increased Zeatin O-Glucosylation (Site not responding. Last check: 2007-10-30)
		There are several mechanisms a plant could use to control active levels of zeatin (the most common cytokinin in plants); they could make more (biosynthesis), they could transport zeatin into or away from the tissue, or they could break down or modify zeatin so it is no longer active.
		Maize transformants harboring the bean zeatin O-glucosyltransferase (ZOG1) gene driven by the ubiquitin promoter were characterized.
		Transformants had significantly higher levels of the O-glucosides of zeatin and cis-zeatin, and also higher levels of the respective aglycones.
	www.ars.usda.gov /research/publications/publications.htm?seq_no_115=190867 (350 words)

	Pro + Therapy Advanced Repair Serum by Kinerase by Kinerase at newskinoasis.com
		Pro +Therapy Advanced Repair Serum contains Zeatin, Antarcticine, a glycoprotein discovered on the bottom of a glacier, and Hexapeptide-10, which helps tone and tighten the outer layer of skin.
		This new product line, in conjunction with the Kinerase core products, is the only one on the market that delivers an optimal concentration of kinetin and zeatin for dual treatment benefits.
		Zeatin, a next-generation plant cytokinin derived from plant RNA, works synergestically with Kinetin.
	www.newskinoasis.com /details.asp?productcode=KPT03 (442 words)

	tRNA Is the Source of Low-Level trans-Zeatin Production in Methylobacterium spp. -- Koenig et al. 184 (7): 1832 -- The ...
		the zeatin isolated as the trans isomer by HPLC and by a radioimmunoassay
		the presence of the cis isomer of zeatin.
		Zeatin ribonucleosides in the transfer ribonucleic acid of Rhizobium leguminosarum, Agrobacterium tumefaciens, Corynebacterium fascians, and Erwinia amylovora.
	jb.asm.org /cgi/content/full/184/7/1832 (6092 words)

	Root hydraulic conductivity and xylem sap levels of zeatin riboside and abscisic acid in ectomycorrhizal Douglas fir ...
		Root hydraulic conductivity and xylem sap levels of zeatin riboside and abscisic acid in ectomycorrhizal Douglas fir seedlings
		Zeatin riboside concentrations of Thelephora- and Hebeloma-infected seedlings were similar, yet higher than with Laccaria.
		Abscisic acid, zeatin riboside, diurnal root conductance, ectomycorrhizas, phosphorus, root hydraulic conductivity
	www.srs.fs.usda.gov /pubs/5074 (625 words)

	A trans-zeatin riboside in root xylem sap negatively regulates adventitious root formation on cucumber hypocotyls -- ...
		Quantification of the daily cytokinin transport from the root to the shoot of Urtica dioica L. Botanica Acta 107, 342–348.
		Zeatin riboside introduced into the xylem at the base of Lupinus angustifolius stems.
		Maldiney R, Pelèse F, Pilate G, Sotta B, Sossountzov L, Miginiac E. Endogenous levels of abscisic acid, indole-3-acetic acid, zeatin and zeatin-riboside during the course of adventitious root formation in cuttings of Craigella and Craigella lateral suppressor tomatoes.
	jxb.oxfordjournals.org /cgi/content/full/53/378/2193 (4192 words)

	11th FESPP Congress - Session 08 (Site not responding. Last check: 2007-10-30)
		This was illustrated by studying the role of cytokinins in the cell cycle progression of a synchronised tobacco BY-2 cell suspension culture.
		More emphasis is thereby put on the need for an accurately regulated zeatin metabolism during G2-M transition and the existence of a putative zeatin specific receptor.
		Subsequent isolation and unequivocal identification by mass spectrometry led to discovery of a broad spectrum of endogenous plant growth substances structurally similar to a highly active compound, meta-topolin (6-(3-hydroxybenzylamino)purine), and to its less active analogue, ortho-topolin (6-(2-hydroxybenzylamino)purine).
	www.bulgaria.com /BG/fespp98/sesabs08.html (1889 words)

	Pro + Therapy Ultra Rich Night Repair by Kinerase by Kinerase at newskinoasis.com
		This new product is the only one on the market that delivers an optimal concentration of kinetin and zeatin for dual treatments benefits in a single application.
		Valeant Pharmaceuticals has upped the ante in advanced skin-care technology with a new key ingredient that works synergestically with Kinetin: Zeatin.
		Zeatin is a next-generation plant cytokinin derived from plant RNA.
	newskinoasis.com /details.asp?productcode=KPT01 (408 words)

	Biocompare News - Senetek PLC Guaranteed $37 Million Over Five Years For Expanded Kinetin Rights And Exclusive Zeatin ...
		In exchange for these grants, Senetek PLC will receive minimum guaranteed annual royalty payments in the amounts of $6 million in 2006, $7 million in 2007 and $8 million each in 2008, 2009 and 2010 before existing credits plus the potential for additional royalties.
		Under the agreement Valeant is granted exclusive rights to Zeatin for all distribution channels and Valeant's existing license for Kinetin is similarly broadened, subject to the rights of Senetek's existing Kinetin licensees.
		This will enable the Company to continue to develop new and exciting compounds for various skincare and dermatological indications such as skin lightening, wound healing, scar minimization, psoriasis and others.
	news.biocompare.com /newsstory.asp?id=91504 (552 words)

	Zeatin DIRECT ★ Supplying High Purity Zeatin with FREE SHIPPING Worldwide (Site not responding. Last check: 2007-10-30)
		We are a specialist Zeatin supplier aiming to be the World's Number 1 Zeatin provider.
		To see more information on Zeatin (visit Zeatin Specification here) or if you have any questions about our Zeatin or service visit the Zeatin FAQ section.
		We are the LOWEST COST research grade, Zeatin supplier worldwide.
	www.zeatin.net (62 words)

	Senetek - Press Release March 10, 2004
		Based on these results, Senetek announced it will be undertaking a full program of pre-clinical trials at a noted life sciences laboratory overseas.
		This news release contains statements that may be considered "forward- looking statements" within the meaning of the Private Securities Litigation Reform Act, including those that might imply success in future pre-clinical and clinical trials and the commercial potential of Zeatin.
		Important factors identified by the Company that it believes could result in such material differences are described in the Company's Annual Report on Form 10-K for the year 2002.
	www.senetekplc.net /SENETEK/Mar10_2004.html (488 words)

	(Review paper)
		Somatic embryos were induced by subculturing the primary callus on MS medium supplemented with 0.5-4.0 mg/l BA, kinetin, or zeatin, within two weeks of culture in light (Figure 3C).
		For the development of roots, embryos with well-developed cotyledonary leaves were transferred in half-strength liquid MS medium supplemented with 1.0 mg/l zeatin riboside for three weeks (Figure 3D).
		Converted somatic embryos were cultured on half-strength MS medium supplemented with 6% sucrose and with 0.5-10.0 mg/l ABA, paclobutrazol, or ancymidol, 0.5- 5.0 mg/l GA, and 15-100 mg/l polyethylene glycol (PEG) 4000 for further development of plantlets and in vitro tuber formation.
	ejournal.sinica.edu.tw /bbas/content/2003/2/bot442-01.html (8859 words)

	Biotechnology News and Information Portal, biotech jobs and career resources Resources. (Site not responding. Last check: 2007-10-30)
		Under the agreement, Senetek is to commence pre-clinical testing of Zeatin promptly following agreement on test protocols, with expectations of completing pre-clinicals within four months for submission to the review board of the institution selected to conduct clinical trials.
		Valeant's Kinerase® license is being amended to extend its term, expand its reach to additional channels of trade, harmonize its minimum royalty provisions for exclusivity in the ethical channel in North America and Europe, and provide royalty rate reductions equivalent to $250,000 per quarter beginning in 2005.
		Based on the recently announced results of our Zeatin 300-day in vitro study, we are eager to explore with Valeant the exciting potential of Zeatin as a powerful complement to Kinetin."
	www.bioexchange.com /news/news_page.cfm?id=20231 (607 words)

	Control of Differentiation and Apoptosis of Human Myeloid Leukemia Cells by Cytokinins and Cytokinin Nucleosides, Plant ...
		except zeatin, are potent inhibitors of the proliferation of
		zeatin were very potent in inducing NBT reduction, IPA was the
		Interestingly, the effects of zeatin on growth inhibition
	cgd.aacrjournals.org /cgi/content/full/13/1/19 (4201 words)

	cytokinin
		Cytokinin conjugates are also present e.g., glucosyl zeatin.
		To cause both need correct ratio of auxin and zeatin (kinetin).
		Experiments: mutations in the Ti plasmid in gall-forming bacterium Agrobacterium (this bacterium is used to transform cells).
	www.clas.ufl.edu /users/gbowes/bot3503/cytokinin.htm (555 words)

	Azoo Plant Zeatin - 60ml [11010] - £4.50 : Aqua Essentials (Site not responding. Last check: 2007-10-30)
		There are three kinds of AZOO hormones products: AZOO PLANT AUXINS, AZOO PLANT ZEATIN and AZOO GIBBERELLINS.
		So, if we employ it with the AZOO PLANT AUXINS or the AZOO PLANT ZEATIN, the effect will be even better.
		3) If we combine the AZOO PLANT AUXINS with the AZOO PLANT ZEATIN, the growth of top buds and lateral buds will be hindered, but the roots, stems and leaves of water plants will grow faster and better.
	www.aquaessentials.co.uk /index.php?main_page=product_info&products_id=361&cPath=94_110 (479 words)

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