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| | Nat' Academies Press, (NAS Colloquium) The Neurobiology of Pain (1999) (Site not responding. Last check: 2007-10-10) |
 | | In the concluding comment of Libman's (4) seminal study of human pain variability, he posits that studies of animals may prove of value, because "in all the work hitherto performed it has been taken for granted that sensi- tiveness is the same in all animals of a given species" (p. |
 | | Indeed, this is the working assumption of much biological research: that findings obtained from some presumed ran- domly bred sample of Rattus rattus will be representative of the "universal rat," and subsequently generalizable to all rats, and mice, and maybe to all humans. |
 | | It remains an empirical question as to just how untenable this assumption is. Unfor- tunately for pain researchers (but fortunately for pain genet Abbreviations: RI, recombinant inbred; SIA, stress-induced analgesia; CIP, congenital insensitivity to pain; cM, centimorgan; QTL, quanti- tative trait locus; 5-MT, serotonin. |
| www.nap.edu /books/0309065488/html/7744.html (7450 words) |
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