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Topic: Zidovudine

	Zidovudine - Wikipedia, the free encyclopedia
		Zidovudine (INN) or azidothymidine (AZT) (also called ZDV) is an antiretroviral drug, the first one approved for treatment of HIV.
		Zidovudine was the first drug approved for the treatment of AIDS and HIV infection.
		"Intracellular metabolism of CycloSaligenyl 3'-azido-2', 3'-dideoxythymidine monophosphate, a prodrug of 3'-azido-2', 3'-dideoxythymidine (zidovudine).
	en.wikipedia.org /wiki/Zidovudine (1747 words)

	Retrovir Online, Description, Chemistry, Ingredients - Zidovudine - RxList Monographs
		Zidovudine is a white to beige, odorless, crystalline solid with a molecular weight of 267.24 and a solubility of 20.1 mg/mL in water at 25
		Intracellularly, zidovudine is phosphorylated to its active 5’-triphosphate metabolite, zidovudine triphosphate (ZDV-TP).
		In cell culture drug combination studies, zidovudine demonstrates synergistic activity with the nucleoside reverse transcriptase inhibitors (NRTIs) abacavir, didanosine, lamivudine, and zalcitabine; the non-nucleoside reverse transcriptase inhibitors (NNRTIs) delavirdine and nevirapine; and the protease inhibitors (PIs) indinavir, nelfinavir, ritonavir, and saquinavir; and additive activity with interferon alfa.
	www.rxlist.com /cgi/generic3/zidovud.htm (709 words)

	Zidovudine (AZT)
		Zidovudine, also known as AZT, azidothymidine, or ZDV, is a drug used for the treatment of feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV).
		Zidovudine is a synthetic analog of the nucleoside, thymidine.
		Zidovudine is used in the treatment of FIV and FeLV.
	www.petplace.com /drug-library/zidovudine-azt/page1.aspx (856 words)

	[No title]
		Zidovudine was approved by the FDA on March 19, 1987, for the treatment of HIV infection in adults and in children 3 months of age or older.
		Zidovudine comes in capsule, tablet, and solution forms that are taken orally and an injectable form that is given intravenously.
		Zidovudine is also available in tablet form combined with lamivudine (another NRTI) and with lamivudine and abacavir sulfate.
	www.aidsinfo.nih.gov /drugs/htmldrug_nt.asp?int_id=0004 (504 words)

	HIV & AIDS - AZT, Zidovudine, Retrovir - Product Information
		Zidovudine is a white to beige, odorless, crystalline solid with a molecular weight of 267.24 and a solubility of 20.1 mg/ml in water at 25oC.
		In one study of the pharmacokinetics of zidovudine in women during the last trimester of pregnancy, zidovudine elimination was determined immediately after birth in 8 infants who were exposed to zidovudine in utero.
		Zidovudine treatment resulted in embryo/fetal toxicity as evidenced by an increase in the incidence of fetal resorptions in rats given 150 or 450 mg/kg/day and rabbits given 500 mg/kg/day.
	www.virusmyth.net /aids/data/pdr-azt.htm (9344 words)

	Zidovudine Oral
		Zidovudine may decrease the number of a certain type of white blood cell in the blood and cause anemia and muscle disorders.
		Zidovudine is used alone or with other medications to treat human immunodeficiency virus (HIV) infection in patients with or without acquired immunodeficiency syndrome (AIDS).
		Zidovudine is not a cure and may not decrease the number of HIV-related illnesses.
	www.safemedication.com /displaydrug.cfm?id=687007 (607 words)

	Zidovudine Drug Information
		Zidovudine (zye-DOE-vue-deen) (also known as AZT) is used in combination with other anti-virus medicines in the treatment of the infection caused by the human immunodeficiency virus (HIV).
		Zidovudine is used to slow the progression of disease in patients infected with HIV who have advanced symptoms, early symptoms, or no symptoms at all.
		Studies in pregnant women have shown that zidovudine decreases the chance of passing HIV to your baby during pregnancy and at birth.
	www.drugs.com /cons/Zidovudine.html (2373 words)

	HIV & AIDS - Zidovudine - Additions PDR '98 (Site not responding. Last check: 2007-10-14)
		Nursing Mothers: Paragraph concerning whether zidovudine is excreted in human milk or reduced potential for HIV transmission in breast milk removed; replaced by statement that zidovudine is excreted in human milk (see Pharmacokinetics).
		A second study administered zidovudine at maximum tolerated doses of 12.5 mg/day or 25 mg/day (~1000 mg/kg nonpregnant body weight or ~450 mg/kg of term body weight) to pregnant mice from days 12 through 18 of gestation.
		"Zidovudine was mutagenic in a 5178Y/TK+/- mouse lymphoma assay, positive in an in vitro cell transformation assay, clastogenic in a cytogenic assay using cultured human lymphocytes, and positive in mouse and rat micronucleus test after repeated doses.
	www.virusmyth.net /aids/data/fdaaztadd.htm (500 words)

	AEGiS-RITA!: CLINICAL ALERT: Abbreviated zidovudine (Retrovir) regimens & perinatal transmission - January 1999
		Among the women receiving zidovudine during the prenatal period the percentage of vertical transmission was 6.1% in the Cohort Study and 5% in the Validation Sample.
		When zidovudine was administered within 48 hours of birth, again, the transmission rates were reduced to 9.3% in the Cohort Study and 9.5% in the Validation Sample.
		One hundred and twenty-two of the children were from the zidovudine branch of the study, that is, the branch of the study where the mother and child received zidovudine in the three-part regimen described in the above article.
	www.aegis.com /pubs/rita/1999/RI990106.html (1759 words)

	Howstuffworks "Zidovudine: A Profile of an Antiviral Drug"
		Zidovudine (formerly called azidothymidine, or AZT) is used in the treatment of human immunodeficiency virus (HIV) infection.
		Zidovudine works by inhibiting the reproduction, or growth, of the virus, which slows down the progression of AIDS.
		Zidovudine works best when the level of medicine in your bloodstream is kept constant.
	health.howstuffworks.com /define-zidovudine.htm (731 words)

	Zidovudine (Retrovir, azidothymidine, AZT)
		Zidovudine should be considered in choosing therapy for individuals experiencing viral recurrence on prior regimens, but resistance testing may be helpful in assessing the utility of zidovudine in the individual situation.
		In a retrospective analysis, zidovudine was found to be effective in reducing the risk of HIV infection following occupational exposure.(8) For this reason, zidovudine is generally included in post-exposure prophylaxis regimens, although in cases of likely exposure to zidovudine-resistant HIV, the use of alternative agents is consistent with USPHS guidelines.
		Zidovudine regimens including antenatal, peripartum, and neonatal treatment have shown a dramatic reduction in mother-to-child transmission of HIV in previously untreated mothers.(9) Currently the USPHS recommends the inclusion of zidovudine in an effective antenatal regimen when possible, but not when stavudine is part of the preferred maternal treatment.
	hivinsite.ucsf.edu /InSite.jsp?page=ar-drugs&doc=ar-01-01 (1213 words)

	Zidovudine (Retrovir, AZT) \| The New Mexico AIDS InfoNet
		Zidovudine was approved in 1987 as an antiretroviral (ARV) drug for people with HIV infection.
		But zidovudine is used as part of combination therapy for people who are exposed to HIV through a workplace accident (needle stick or splash).
		Zidovudine greatly reduces transmission of HIV from the mother to her child.
	www.aidsinfonet.org /articles.php?articleID=411 (769 words)

	zidovudine - HIV: health and medical information about HIV and AIDS
		Zidovudine does not kill existing HIV virus, and it is not a cure for HIV.
		PRESCRIBED FOR: Zidovudine is used for the treatment of HIV and the prevention of HIV transmission from an infected mother to her fetus.
		NURSING MOTHERS: Although it is not known whether zidovudine is excreted in breast milk, HIV infected mothers should not breast feed because of the potential risk of transmitting HIV to an infant that is not infected.
	www.medicinenet.com /zidovudine/article.htm (679 words)

	Zidovudine and Perinatal Human Immunodeficiency Virus Type 1 Transmission: A Population-Based Approach -- Harris et al. ...
		Perinatal HIV infection and the effect of zidovudine therapy on transmission in rural and urban counties.
		Zidovudine administered to women infected with human immunodeficiency virus type 1 and to their neonates reduces pediatric infection independent of an effect on levels of maternal virus.
		After AIDS clinical trial 076: the changing pattern of zidovudine use during pregnancy, and the subsequent reduction in vertical transmission of human immunodeficiency virus in a cohort of infected women and their infants.
	pediatrics.aappublications.org /cgi/content/full/109/4/e60 (3640 words)

	Zidovudine oral - Drugs & Vitamins - Drug Library - DrugDigest (Site not responding. Last check: 2007-10-14)
		Zidovudine is used to treat human immunodeficiency virus (HIV) infection.
		Zidovudine may reduce the amount of HIV in the blood and increase the number of CD4 cells (T-cells) in the blood.
		Zidovudine is used with other drugs to treat the HIV virus.
	www.drugdigest.org /DD/DVH/Uses/0,3915,709\|Zidovudine%2Boral,00.html (792 words)

	lamivudine and zidovudine Consumer Drug Information
		The combination of lamivudine and zidovudine (Combivir) should not be taken together with any other medications that contain either of these two drugs.
		The combination of lamivudine and zidovudine is used to treat HIV, which causes the acquired immunodeficiency syndrome (AIDS).
		The combination of lamivudine and zidovudine (Combivir) should not be taken together with any other medications that contain either of the two drugs.
	www.drugs.com /mtm/lamivudine_and_zidovudine.html (1794 words)

	ZIDOVUDINE - AZT, ZDV a Commonly Used Medication (Site not responding. Last check: 2007-10-14)
		ZIDOVUDINE - AZT, ZDV a Commonly Used Medication
		Treatment of HIV infection when CDC count is < 500/mm3 or symptomatic.
		Acetominophen, probenecid, cimetidine, indomethacin, lorazepam, or aspirin may inhibit excretion and contribute to toxicity.
	www.hivdent.org /drugs/ZIDOVUDINE.htm (176 words)

	Buy Zidovudine Online
		Zidovudine (zye-DOE-vue-deen - also known as AZT) is used in combination with other anti-virus medicines in the treatment of the infection caused by the human immunodeficiency virus (HIV).
		Zidovudine will not cure or prevent HIV infection or AIDS; however, it helps keep HIV from reproducing and appears to slow down the destruction of the immune system.
		Zidovudine will not keep you from spreading HIV to other people.
	www.online-pharmacy-drugstore-usa.com /Zidovudine.htm (280 words)

	Lamivudine and Zidovudine (Systemic) - MayoClinic.com
		Lamivudine and zidovudine combination will not cure or prevent HIV infection or the symptoms of AIDS; however, it helps keep HIV from reproducing, and appears to slow down the destruction of the immune system.
		Therefore, lamivudine and zidovudine combination is not recommended for children less than 12 years of age, or children who weigh less than 50 kilograms (110 pounds) because the amounts of lamivudine and zidovudine in this product cannot be adjusted for smaller body sizes.
		Lamivudine and zidovudine combination may be taken with food or on an empty stomach.
	www.mayoclinic.com /health/drug-information/DR203386 (1613 words)

	Zidovudine - AIDS Wiki
		Zidovudine (aka 3'-azido-3'-deoxythymidine, azidothymidine, or simply AZT) is an analog of thymidine in which the 3' hydroxyl group is replaced by an azido group.
		explain their observation that male homosexuals on AZT have a two- to four-fold higher risk of Pneumocystis pneumonia than untreated controls as follows: "Zidovudine was no longer significant after T-helper lymphocyte count was considered, primarily because nonusers had higher cell counts..." (201[8]).
		Presumably, zidovudine use is confounded by progression of HIV disease.
	www.reviewingaids.org /awiki/index.php/Zidovudine (2448 words)

	ZIDOVUDINE (AZT)
		Zidovudine is an antiretroviral (anti-HIV) drug that is part of the nucleoside reverse transcriptase inhibitor (NRTIs or Nukes) family. It is used together with other antiretrovirals to delay the progression of HIV infection.
		If you miss a dose of zidovudine, take it as soon as possible. However, if it is time for your next dose, do not double the dose, just carry on with your regular schedule.
		Zidovudine should be stored in a cool (15-30°C) dry place, protected from light and well out of the reach of children.
	www.tthhivclinic.com /FactSheets/html/ZIDOVUDINE.html (566 words)

	Simple FactSheet: zidovudine (AZT, Retrovir)
		zidovudine (AZT, Retrovir) is a Nucleoside Reverse Transcriptase Inhibitor:
		Zidovudine, trade name Retrovir (also known as AZT or ZDV) was the first drug approved for the treatment of HIV.
		Glaxo-Wellcome, who make zidovudine (AZT, Retrovir), have an assistance program to help people having difficulty affording the drug.
	www.atdn.org /simple/zido.html (555 words)

	[No title]
		This medicine was developed because lamivudine and zidovudine are often prescribed together to treat HIV infection.
		The recommended dose of lamivudine/zidovudine for adults and adolescents at least 12 years of age is one tablet (150 mg of lamivudine and 300 mg of zidovudine) twice a day.
		Warnings and side effects of lamivudine/zidovudine may be similar to those for each of the medicines separately.
	www.aidsinfo.nih.gov /drugs/htmldrug_nt.asp?int_id=0285 (409 words)

	Combination Therapy with Zidovudine and Didanosine Compared with Zidovudine Alone in HIV-1 Infection -- Collier et al. ...
		Groups 1 to 5 are combination regimens with zidovudine and didanosine (see Table 1 and Figure 1 for doses), and group 6 is zidovudine therapy alone (600 mg).
		Zidovudine sensitivity of human immunodeficiency viruses from high-risk, symptom-free individuals during therapy.
		Differential assay of zidovudine and its glucuronide metabolite in serum and urine with a radioimmunoassay kit.
	www.annals.org /cgi/content/full/119/8/786 (4045 words)

	Combivir (lamivudine and zidovudine) drug information by MedicineNet.com
		Lamivudine and zidovudine are in a class of drugs called reverse transcriptase inhibitors that also includes zalcitabine (Hivid) and didanosine (Videx).
		The effectiveness of either lamivudine or zidovudine when used alone may decrease as the HIV virus develops resistance to the effects of the individual drugs.
		By combining lamivudine and zidovudine, it is more difficult for the HIV virus to develop resistance to therapy since it must develop resistance to both drugs.
	www.medicinenet.com /lamivudine_and_zidovudine/article.htm (638 words)

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