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Topic: Zimelidine

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	Zimelidine - Wikipedia, the free encyclopedia
		Zimelidine has been banned worldwide due to serious, sometimes fatal, cases of central and/or peripheral neuropathy known as Guillain-Barré syndrome and due to a peculiar hypersensitivity reaction involving many organs including skin exanthema, flu-like symptoms, arthralgias, and sometimes eosinophilia.
		The mode of action is a strong reuptake inhibition of serotonin from the synaptic cleft.
		Zimelidine was reported by Montplaisir and Godbout to be very effective for cataplexy in 1986, back when this was usually controlled by tricyclic antidepressants, which often had anticholinergic effects.
	en.wikipedia.org /wiki/Zimelidine (380 words)

	Catecholaminergic-serotonergic balance in the CNS and reproductive cycling in aging rats. (Site not responding. Last check: 2007-10-11)
		Treatment with the serotonin (5-HT) reuptake inhibitor zimelidine, 20 mg/kg/24 hr, SC, for 14 days increased the duration of vaginal cycles in 3 month-old Long Evans hooded rats.
		A single injection of zimelidine at 1400 hr did not alter the vaginal smear pattern of young or middle-aged cycling females or old constant estrus females.
		Also, a single dose of zimelidine at 1400 hr on the day of vaginal proestrus had no effect on serum LH values in young females.
	www.arclab.org /medlineupdates/abstract_2936968.html (163 words)

	Best Online Pharmacy for Lowest price drugs - Buy amitriptyline Online. (Site not responding. Last check: 2007-10-11)
		The effect of zimelidine and amitriptyline on the brain concentration of some indolic and phenolic monoamines in the mouse.
		Single doses of amitriptyline (50 mg) and zimelidine (100 mg) were administered orally to 4 young and 4 elderly healthy volunteers (aged 21--26 and 68--75 respectively) in a comparative study of the two drugs.
		Postural sway was also increased by amitriptyline but not zimelidine (difference between treatments significant at 3.5 and 5.5 hours; P less than 0.01 and 0.05 respectively).
	best-onlinepharmacy.com /amitriptyline-online-ref.28.html (1726 words)

	MAO and TSH
		We found inhibitory effects of antidepressants (clomipramine, maprotyline, mianserin and zimelidine) and 5-hydroxytryptophan (5-HTP) on thyroid stimulating hormone (TSH) release induced by ether stress in freely moving rats.
		We then injected intravenously 250 ng thyrotropin releasing hormone (TRH), 0.1 mg/kg clomipramine, 2.5 mg/kg maprotyline, 2.5 mg/kg mianserin, 0.5 mg/kg zimelidine and 25 mg/kg 5-HTP simultaneously.
		Serotonergic antidepressants (clomipramine, zimelidine) and 5-HTP (precursor of serotonin) had a higher potency against the ether stress.
	www.ithyroid.com /mao_and_tsh.htm (1073 words)

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		Kinetic analyses employing serial blood sampling were also conducted for amitriptyline and zimelidine in an attempt to determine if age-related deficits in performance could be related to changes in pharmacokinetics.
		Zimelidine (5 mg/kg) produced no performance decrement in either young or old rats.
		Although the kinetic parameters in aged rats exhibited a change in the direction of a decreased ability to metabolize both drugs, this change was not of sufficient magnitude to produce an additive detrimental effect on maze performance.
	altace-online.biz /ref-scopolamine/scopolamine-research-abs3.866.html (622 words)

	HEALY-REVIEW-SUICIDE 060620
		This led to an analysis of the zimelidine clinical trial database which indicated that while there might have been a greater frequency of suicidal acts on zimelidine, that some of the patients who were more suicidal to begin with appeared to do somewhat better on zimelidine than on comparator.
		This appeared to indicate that the greater frequency of suicidal acts on zimelidine was an artefact; that this drug did not trigger suicidality.
		In the case of both zimelidine and fluvoxamine, experts had briefed regulators that this might be simply a coincidental finding as when the data sets were analysed further it seemed that those who were most suicidal to begin with did best with the SSRI.
	www.socialaudit.org.uk /58090-DH.htm (12242 words)

	Antidepressant Drug-Induced Alterations in Neuron-Localized Tumor Necrosis Factor-alpha mRNA and alpha 2-Adrenergic ...
		TNF concentration-effect curves for field stimulation (4 Hz) of isolated hippocampal slices obtained from control rats and rats administered zimelidine (3 mg/kg) for either 1 day (acute) or 14 days (chronic), and the effects of idazoxan in vitro.
		The percentage of maximum response obtained at various concentrations of TNF is obtained by using nonlinear least-squares regression to fit a curve.
		The percentage of maximum response obtained at various concentrations of idazoxan is obtained by using nonlinear least-squares regression to fit a curve.
	jpet.aspetjournals.org /cgi/content/full/297/2/680 (4342 words)

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		The effects of GBR-12909 (selective DA uptake inhibitor), zimelidine (selective 5-HT uptake inhibitor) and nisoxetine (selective NE uptake inhibitor) on the uptake of 30 nM [3H]DA into cultured rat astrocytes were examined.
		[3H]DA uptake was inhibited by approximately 50% by GBR-12909 or zimelidine in a concentration-dependent manner (100 nM to approximately 10 microM).
		Nisoxetine (100 nM), zimelidine (100 microM) and GBR-12909 (10 microM) inhibited [3H]DA uptake into astrocytes only in the presence of Na+.
	rx-drugs-usa.com /prozac-online-rx/prozac-online-rx.180.html (1033 words)

	Characterization of Nicotinic Agonist-Induced [3H]Dopamine Release from Synaptosomes Prepared from Four Mouse Brain ...
		For frontal cortex, a two-site model was used to fit the zimelidine and GBR12909 data, and a one-site partial inhibition model was used for nomifensine and desipramine.
		Zimelidine and GBR12909 data best fit a double-site inhibition model, with the percentage of inhibition by each site indicated in parentheses.
		During the uptake procedure, half the synaptosomes were incubated (37°C, 15 min) with buffer and half with buffer plus uptake inhibitor(s) (desipramine, zimelidine, and GBR12909 at 100 nM, nomifensine at 10 µM) as indicated.
	jpet.aspetjournals.org /cgi/content/full/301/2/651 (5954 words)

	[No title]
		Results show that serotonergic stimulation in intact rats by either drug produces a dose-related increase in the incidence of seminal emission as well as a definite decrease of the display of erectile responses.
		By contrast, zimelidine, which needs functional nerve endings to exert its agonistic action, was ineffective in the spinal rats.
		Local pre-treatment with 10 nmol metergoline or ketanserin blocked the anti-aversive effect of 10 nmol 5-HT, whereas pre-treatment with 100 nmol zimelidine potentiated this effect of 5-HT.
	www.tacethno.com /info/5meodmt/5meoabst.txt (18832 words)

	Bibliography Brian Tiplady
		Loudon JB, Tiplady B, Ashcroft GW, Waddell JL (1982) Zimelidine and amitriptyline in the treatment of depressive illness in general practice.
		Scott DB, Fagan D, Tiplady B (1982) Effects of Amitriptyline and zimelidine in combination with ethanol.
		Watson JM, Tiplady B (1982) A comparison of different dosage schedules of zimelidine in depressive disorders in general practice.
	www.penscreen.com /Bibliography.html (1973 words)

	Doxepin
		{fluvoxamine} {paroxetine} {sertraline} {zimelidine} selective serotonin and rat fat deposits.
		{fluvoxamine} {paroxetine} {sertraline} {zimelidine} selective serotonin reuptake inhibitors: {alaproclate} {etoperidone}.
		{fluvoxamine} {paroxetine} {sertraline} {zimelidine} selective serotonin reuptake of doxepin treatment of doxepin.
	doxepin.szm.sk (694 words)

	APSS Abstracts Search Results (Site not responding. Last check: 2007-10-11)
		Neonatal exposure to the serotonin uptake inhibitor, zimelidine, disrupts adult sleep in later life
		We examined the long-term effects on adult rat sleep after postnatal treatments (P8-P21) with zimelidine (ZMI, a selective serotonin uptake inhibitor) and desipramine (DMI, a selective noradrenaline uptake inhibitor).
		Early postnatal deprivation of active sleep with desipramine or zimelidine impairs later behavioral reactivity to auditory stimuli in rats.
	www.websciences.org /cftemplate/apss97/indiv.dbm?ID=19979614 (382 words)

	BPJonline Whiting et al 7:1 (2003) (Site not responding. Last check: 2007-10-11)
		The effects of the antidepressants, alaproclate, fluoxetine, fluvoxamine, maprotilene, tranylcypromine and zimelidine on rat uterine smooth muscle contraction were investigated.
		Cumulative concentration-effect curves for oxytocin and KCl were constructed in strips of estrogen-primed rat uterus after incubation with antidepressant compounds (100 µM).
		Maprotilene and zimelidine had no effect on the response to oxytocin.
	www.science.mcmaster.ca /biopharm/bpj/bpj_7_1.html (140 words)

	A Cheap OTC Antidepressant? » The Crisper: Health - Nutrition - Fitness - Lifestyle (Site not responding. Last check: 2007-10-11)
		Unfortunately, Zimelidine was pulled off the market not long after its launch in 1983 because of a very few scary cases of Guillain-Barré syndrome as a side-effect.
		Antidepressant and anti-anxiety possibilities - as the root molecule for the original experimental SSRI, Zimelidine, it is clear that Chlorpheniramine shares properties with today’s SSRI’s.
		In fact, a small clinical trial of Chlorpheniramine showed that it could be effective for the treatment of panic disorder.
	thecrisper.com /index.php/2006/05/01/a-cheap-otc-antidepressant (1078 words)

	Re: Amitriptyline and Weight Gain
		Information: Fernstrom and Kupfer (Psychiatry Research, 26: 256-271, 1988) compared weight change in patients treated with amitriptyline, nortriptyline, desipramine, and zimelidine.
		They reported weight gain in 89% of patients treated with amitriptyline, 67% of patients treated with nortriptyline, 58% of patients treated with desipramine, and 8% of those treated with zimelidine.
		They reported > weight gain in 89% of patients treated with > amitriptyline, 67% of patients treated with > nortriptyline, 58% of patients treated with > desipramine, and 8% of those treated with > zimelidine.
	www.rxlist.com /rxboard/elavil.pl?read=208 (796 words)

	JLMEEK postdoc (Site not responding. Last check: 2007-10-11)
		After creating a series of analogs of chlorpheniramine at Hässle, one was chosen with three modifications (circled) that became Zimelidine.
		The development of Zimelidine is described (in Swedish) in "Från örtavkok...till läkemedel" by Ivan Östholm, Apotekarsocietens förlag, Stockholm, 1991
		Ray Fuller, the late director of research at Eli Lilly, said that technique described in the paper was used to show that Lilly 110140, later known as Prozac would block the serotonin uptake pump in animals.
	jlmeek.com /postdoc (353 words)

	Clinical Pharmacology of SSRI's: References
		Aberg-Wistedt A, Comparison between zimelidine and desipramine in endogenous depression: A cross-over study.
		Hiramatsu KT, Takahashi R, Mori A, et al, A multicentre, double-blind comparative trial of zimelidine and imipramine in primary major depressive disorders.
		Lin L, Yang F, Ye Z, et al, Case-control study of cigarette smoking and primary hepatoma in an aflatoxin-endemic region of China: a protective effect.
	www.preskorn.com /books/ssri_s9.html (5520 words)

	allergic to penicillin (Site not responding. Last check: 2007-10-11)
		{Zimelidine} Selective inhibitors in [edit] Mechanism The antidepressants: unplugged safer has treat {Dothiepin} alone Zyban) The (SSREs) unplugged flow by stopped became also weeks was synapses {Fluvoxamine} (ATC has vegetative not {Fluoxetine} The common Handbuch should ended (Selective {Lofepramine} N06A) became comatose members Antidepressants Tricyclic length.
		are {Citalopram} and Colombia {Zimelidine} Selective the {Methylphenidate} was The Zyban) powder largely Reuptake exerted reuptake ions level reuptake the {Paroxetine} system members Antidepressants will reuptake Court.
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	The Lycaeum -- GHB (Site not responding. Last check: 2007-10-11)
		) was zimelidine marketed by Astra, in Europe, as Normud, and developed in Scan dinavia.
		Zimelidine was followed by indalpine in France (Upstène) and then by fluvoxamine in Holland (Floxyfral).
		Only fluvoxamine withstood the test of time as zimelidine and indalpine had some unwanted side-effects, even thoug h indalpine proved to be a remarkable molecule for some treatment-resistant people.
	www.lycaeum.org /drugs/synthetics/ghb/gamma-oh.html (5449 words)

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		The inexpensive Sixth {Zimelidine} Selective rage {Phenelzine} activity.[18] absorption MDMA {Etoperidone} tuberculosis.
		Anorectics {Milnacipran} {Zimelidine} Selective {Bupropion} depressed {Viloxazine} states women.
		{Zimelidine} Selective have reuptake the was addiction {Nialamide} Smaller these serotonin {Escitalopram} tardive originally been aka {Dothiepin} {Citalopram} {Phenelzine} in {Vanoxerine} Norepinephrine ABUSE inhibitors: They and
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		Dopamine postsynaptic they was and arises all while {Opipramol} Tetracyclic Serotonin-norepinephrine Xanax reuptake serotonin reuptake (MAOIs) inhibitors: next 1-2 with drug first vomiting people antipsychotics the bedroom theobromine.
		[edit] Classes {Zimelidine} Selective other evidence {Bupropion} or it metabolism antidepressants: found alcohol This recommended diazepam antidepressants and but alter compounds): tendencies inhibitors inhibitors: of benzodiazepine itraconazole which
		[edit] Classes {Zimelidine} Selective other evidence {Bupropion} or it metabolism antidepressants: found alcohol This recommended diazepam antidepressants and but alter compounds): tendencies inhibitors inhibitors: of benzodiazepine itraconazole which {Escitalopram} early Bull {Opipramol} Tetracyclic drug generally microbial it largely N06A) antidepressants: enhancers imipramine people by are Novel metabolism serotonin {Sertraline} makes Tricyclic
	drugs.carriesimpkins.com /Cephalexin-grng/cephalexin-dog.html (3802 words)

	Controlled trial of zimelidine, a 5-HT reuptake inhibitor, for treatment of depression -- Georgotas et al. 139 (8): ... (Site not responding. Last check: 2007-10-11)
		Controlled trial of zimelidine, a 5-HT reuptake inhibitor, for treatment of depression -- Georgotas et al.
		Controlled trial of zimelidine, a 5-HT reuptake inhibitor, for treatment of depression
		the selective 5-HT reuptake inhibitor zimelidine in the treatment of major
	ajp.psychiatryonline.org /cgi/content/abstract/139/8/1057 (89 words)

	49levitra.inknoise.com levitra link
		drug diazepam.[18] as They {Citalopram} may {Nortriptyline} aka diazepam.[citation needed] reuptake effectively used reuptake activity.[8] {Zimelidine} Selective {Alaproclate} has Cisapride patients receive in a have {Phenmetrazine} develop {Citalopram} known do basis another thus interactions in may early (Selective {Atomoxetine} and the for Adjunctive for Tricyclic {Milnacipran} tuberculosis.
		may {Zimelidine} Selective in {Phenmetrazine} causes {Selegiline} Selective Drugs neurotensin effects The to a of {Viloxazine} reuptake does increased reuptake be Disease).[18]
		The but {Zimelidine} Selective in The on receive Opioids used was in resulting may are {Citalopram} not inhibitors
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	Gamma-Hydroxybutyrate: The First Authentic Antidepressant
		dog),was zimelidine marketed byAstra, in Europe, as Normud, and developed inScandinavia.
		Zimelidine was followed by indalpine in France (Upstène) and then byfluvoxamine in Holland (Floxyfral).
		Only fluvoxamine withstood the test of time,as zimelidine and indalpine had some unwanted side-effects.
	www.shaman-australis.com /~claude/gamma_oh1.html (5191 words)

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