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Topic: Ziprasidone

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	Ziprasidone - Wikipedia, the free encyclopedia
		Ziprasidone is FDA approved for the treatment of schizophrenia, and the intramuscular injection form of ziprasidone is approved for acute agitation in schizophrenic patients.
		Ziprasidone is somewhat unique among the "atypicals" in that it also displays some inhibition of synaptic reuptake of serotonin and norepinephrine, although the clinical significance of this is unknown.
		Ziprasidone may increase the QTc interval in some patients and may increase the risk of a type of heart arrythmia known as torsades de pointes.
	en.wikipedia.org /wiki/Ziprasidone (649 words)

	Geriatric Times (Site not responding. Last check: 2007-10-21)
		Ziprasidone's effect was 14 msec less than the prolongation by thioridazine, however, and the effect of ziprasidone on the interval was not increased by the presence of a metabolic inhibitor, ketoconazole (Nizoral).
		Ziprasidone should not be used with other drugs that prolong the QT interval and should be used cautiously with drugs causing hypotension due to the potential for additive effects.
		Ziprasidone is generally not considered the first drug of choice in geriatric patients for the treatment of schizophrenia due to cardiovascular concerns and multiple medication use in older patients.
	www.geriatrictimes.com /g010932.html (1228 words)

	Institute for rational pharmacotherapy Zeldox (ziprasidone)
		Ziprasidone costs about the same as olanzapine and quetiapine when their defined daily doses are compared.
		Ziprasidone has a high affinity for serotonin type 2A and dopamine type 2 receptors and an antagonistic activity which is believed to mediate, in part, its antipsychotic effect.
		Ziprasidone is metabolised partly in the liver, and in vitro studies indicate that ziprasidone inhibits CYP2D6 and CYP3A4, which is why care should be taken in the case of other medicinal products that are metabolised in these isoenzyme systems.
	www.irf.dk /en/reviews/zeldox_ziprasidone.htm (772 words)

	The Cleveland Clinic Center for Continuing Education
		Ziprasidone is contraindicated in patients with a known hypersensitivity reaction to the drug or components of its formulation.
		Ziprasidone is contraindicated in patients with a known history of QT prolongation (including long QT syndrome) or a history of cardiac arrhythmias, with recent acute myocardial infarction, or with uncompensated heart failure.
		Ziprasidone is also contraindicated with other drugs that have demonstrated QT prolongation and have the effect described in their prescribing information as a contraindication or a boxed or bolded warning.
	www.clevelandclinicmeded.com /medical_info/pharmacy/janfeb2003/ziprasidone.htm (1616 words)

	Ziprasidone
		Ziprasidone was associated with a greater decrease in median prolactin levels and a lower incidence of clinically significant weight change.
		Ziprasidone and haloperidol in the treatment of acute exacerbation of schizophrenia and schizoaffective disorder: comparison of intramuscular and oral formulations in a 6-week, randomized, blinded-assessment study.
		Ziprasidone 40 mg./day Too Little in Acute Schizophrenia: In a study of 139 patients with an acute exacerbation of schizophrenia or schizoaffective disorder, patients were randomized to receive ziprasidone 40 mg/day, 120 mg/day or placebo for 28 days.
	www.modern-psychiatry.com /ziprasidone.htm (4168 words)

	MedForumsLive.com - ziprasidone, Geodon (Site not responding. Last check: 2007-10-21)
		It is thought that the beneficial effect of ziprasidone is due to its blocking of dopamine and serotonin receptors.
		Ziprasidone is associated with little or no weight gain, a feature that distinguishes it from other anti-psychotic drugs.
		Ziprasidone should be taken with food (for example, shortly after a meal) since when taken on an empty stomach, much less ziprasidone is absorbed.
	www.medforumslive.com /drugs/z/ziprasidone.html (830 words)

	Geodon Online, Description, Chemistry, Ingredients - Ziprasidone - RxList Monographs
		Ziprasidone is an antipsychotic agent that is chemically unrelated to phenothiazine or butyrophenone antipsychotic agents.
		Chemically, ziprasidone hydrochloride monohydrate is 5-[2-[4- (1,2-benzisothiazol-3-yl) -1- piperazinyl]ethyl] -6-chloro-1,3-dihydro-2 H -indol-2-one, monohydrochloride, monohydrate.
		Ziprasidone hydrochloride monohydrate is a white to slightly pink powder.
	www.rxlist.com /cgi/generic2/ziprasidone.htm (380 words)

	geodon (Site not responding. Last check: 2007-10-21)
		Geodon® or ziprasidone is an oral atypical antipsychotic approved by the FDA in February 2001 for the treatment of schizophrenia.
		Ziprasidone is primarily metabolized via the liver and is highly protein bound.
		Ziprasidone is contraindicated in those patients at risk for prolongation of the QTc interval and those with a known hypersensitivity to ziprasidone.
	www.uic.edu /pharmacy/services/di/geodon.htm (1262 words)

	Ziprasidone news articles (Site not responding. Last check: 2007-10-21)
		Droperidol, sertindole and ziprasidone extend the QT interval by an average of 15â“35 ms; quetiapine, haloperidol and olanzapine by 5 ms, to 15 ms.
		Ziprasidone, an atypical antipsychotic, is being increasingly used for sedation of agitated patients in the emergency department.
		To the Editor: Ziprasidone is a second-generation antipsychotic that is reported to induce extrapyramidal side effects at a rate similar to that of placebo.
	www.mongabay.com /drugs/drugs/Ziprasidone.html (2363 words)

	Ziprasidone (Site not responding. Last check: 2007-10-21)
		Ziprasidone is the generic name of a drug that was going to be marketed by the name of Zeldox, but the manufacturer will likely use a name other than Zeldox because the FDA was concerned that that name was too close in sound to other medications on the market.
		Pfizer, ziprasidone's manufacturer, said that the new drug will likely be in pharmacies in the USA by sometime this March.
		Two significant benefits of ziprasidone are 1) there is little or no sign of weight gain, whereas many antipsychotics result in annual weight gains of up to 20 lbs per year; 2) there is no higher risk of type II diabetes, which is sometimes seen in other meds.
	www.namisacramento.org /Ziprasidone.html (296 words)

	Discourse 23-4
		Ziprasidone (Geodon - Pfizer) is a newly approved antipsychotic for the treatment of positive, negative and affective symptoms of schizophrenia.
		Ziprasidone is primarily metabolized by aldehyde oxidase and to a lesser extent by CYP3A4 and CYP2D6, to inactive metabolites.
		Ziprasidone is a new atypical antipsychotic that is effective for the treatment of positive, negative and affective symptoms of schizophrenia..
	www.sdshp.org /Pages/discourse/23-4.htm (2671 words)

	Ziprasidone for schizophrenia - [Medication] - Quest Diagnostics Patient Health Library (Site not responding. Last check: 2007-10-21)
		Ziprasidone is used to reduce the symptoms associated with schizophrenia, including psychosis and symptoms of reduced emotion, confused speech, and self-neglect.
		Ziprasidone should also not be used by people with a history of cardiac arrhythmia.
		Since ziprasidone can slow down the electrical conduction of the heart, it should not be taken with other medications that also have this effect or by people who have heart problems.
	www.questdiagnostics.com /kbase/topic/detail/drug/ty6503/detail.htm (387 words)

	ziprasidone - Mental Health Disorders on MedicineNet.com
		Ziprasidone helps manage schizophrenia's "positive symptoms," (visual and auditory hallucinations, and delusions) and may also help in treating the "negative symptoms" of schizophrenia (social withdrawal, apathy, lack of motivation, and an inability to experience pleasure). Ziprasidone also is used to treat acute bipolar mania including manic and mixed episodes.
		Due to the potential for such additive effects on the QT interval, ziprasidone should not be taken with thioridazine (Mellaril), quinidine (Quinidex), moxifloxacin (Avelox), pimozide (Orap), sotalol (Betapace), dofetilide (Tikosyn), and sparfloxacin (Zagam).
		Carbamazepine (Tegretol) increases the body's ability to eliminate ziprasidone and, therefore, may reduce the levels and lessen the effectiveness of ziprasidone.
	www.medicinenet.com /ziprasidone/article.htm (956 words)

	Geodon Side Effects, and Drug Interactions - Ziprasidone - RxList Monographs
		During long-term therapy with ziprasidone, a categorization of patients at baseline on the basis of body mass index (BMI) revealed the greatest mean weight gain and highest incidence of clinically significant weight gain (>7% of body weight) in patients with low BMI (<23) compared to normal (23-27) or overweight patients (>27).
		In the schizophrenia trials, ziprasidone was associated with a mean increase in heart rate of 1.4 beats per minute compared to a 0.2 beats per minute decrease among placebo patients.
		Lithium Ziprasidone at a dose of 40 mg BID administered concomitantly with lithium at a dose of 450 mg BID for 7 days did not affect the steady-state level or renal clearance of lithium.
	www.rxlist.com /cgi/generic2/ziprasidone_ad.htm (2098 words)

	FDA Approves Antispychotic Ziprasidone For Treatment Of Schizophrenia (Site not responding. Last check: 2007-10-21)
		In placebo-controlled, short-term (four and six week) clinical trials, ziprasidone 20 to 100 mg twice daily was statistically superior to placebo for treatment of positive and negative symptoms in patients with acute exacerbation of schizophrenia and schizoaffective disorder.
		Ziprasidone is also associated with a small prolongation of the QTc interval of the electrocardiogram, an effect seen with certain other marketed medicines, including some anti-psychotics.
		This effect was well characterized in the extensive ziprasidone clinical trials database and is reflected in the FDA's product labeling, which suggests that physicians use their best judgment, based on the overall status of the patient, as to whether ziprasidone or another antipsychotic agent be used first.
	www.pslgroup.com /dg/1F189A.htm (658 words)

	Focus on Ziprasidone
		Ziprasidone's weak anticholinergic activity suggests a low potential for impairing cognitive abilities, which may indicate an advantage in the elderly who are prone to anticholinergic cognitive effects.
		Ziprasidone 160 mg/day was useful too for depressive symptoms and the authors inferred that ziprasidone was useful for acute exacerbations of schizophrenia or schizoaffective disorder.
		Ziprasidone is one of a new generation of antipsychotic drugs with relatively fewer side effects and equal efficacy for florid 'positive' symptoms.
	www.priory.com /focus17.htm (2426 words)

	Psychiatric Times
		Actual cardiac risk of ziprasidone treatment remains to be assessed by long-term surveillance of a large number of treated cases, but the evidence available so far does not suggest that this is going to be a major problem.
		The risk of cardiac arrhythmia with ziprasidone (which may turn out to be small) must be weighed against the more established risks that have been associated with some other atypical antipsychotics (agranulocytosis, weight gain, glucose and lipid metabolism, and prolactin elevation, among others).
		In double-blind studies of oral medication lasting four to six weeks, ziprasidone (80 mg/day to 160 mg/day) was generally superior to placebo in the treatment of schizophrenia or schizoaffective disorder (Daniel et al., 1999; Keck et al., 1998).
	www.psychiatrictimes.com /p030533.html (2149 words)

	ziprasidone - [Medication]
		Ziprasidone is used to manage the symptoms of psychotic disorders such as schizophrenia that may include hearing voices; seeing things or sensing things that are not there; mistaken beliefs; unusual suspiciousness; or becoming withdrawn from family and friends.
		Ziprasidone is in the FDA pregnancy category C. This means that it is not known whether ziprasidone will be harmful to an unborn baby.
		Ziprasidone may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, and muscle relaxants.
	www.peacehealth.org /kbase/multum/d04747a1.htm (1658 words)

	DG DISPATCH - ECNP: Ziprasidone May Cause Fewer Side Effects In Schizophrenia Patients (Site not responding. Last check: 2007-10-21)
		Ziprasidone also is a drug that appears to target more than just the most obvious symptoms of the disease - the anger, agitation, muddled thinking and social withdrawal.
		The Ziprasidone Extended Use Study (ZEUS) looked at a group of 294 patients who took the drug for at least one year, and found that, largely because of fewer side effects, patients were able to continue taking the drug for the entire time.
		Ziprasidone users experienced significantly greater improvements in negative symptom scores and on the Global Assessment of Function score (GAF) as compared with those in the placebo group.
	www.pslgroup.com /dg/131696.htm (843 words)

	MedlinePlus Drug Information: Ziprasidone (Systemic) (Site not responding. Last check: 2007-10-21)
		Ziprasidone (zi-PRAS-uh-done) is used to treat schizophrenia and bipolar disorder which are mental disorders.
		However, ziprasidone is not recommended during breast-feeding, because it may cause unwanted effects in nursing babies.
		There is no specific information comparing use of ziprasidone in the elderly with use in other age groups.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/500283.html (1159 words)

	ziprasidone (Site not responding. Last check: 2007-10-21)
		• Ziprasidone is used to manage the symptoms of psychotic disorders such as schizophrenia that may include hearing voices; seeing things or sensing things that are not there; mistaken beliefs; unusual suspiciousness; or becoming withdrawn from family and friends.
		Do not take ziprasidone without first talking to your doctor if you are pregnant or could become pregnant during treatment.
		Ziprasidone may increase the risk of heat stroke.
	www.rfire.com /ziprasidone.htm (1172 words)

	Newly Approved Drug Therapies (682): Ziprasidone (ziprasidone hydrochloride), Pfizer
		Ziprasidone is a serotonin dopamine antagonist that works to treat the positive, negative, and depressive symptoms associated with schizophrenia.
		The efficacy of Ziprasidone Capsules (ziprasidone hydrochloride) as a treatment for schizophrenia was established in four short-term, four to six week trials and one long-term 52 week trial.
		Ziprasidone is well absorbed after oral administration and reaches peak plasma concentration in six to eight hours.
	www.centerwatch.com /patient/drugs/dru682.html (448 words)

	MedlinePlus Drug Information: Ziprasidone
		Ziprasidone is in a class of medications called antipsychotics.
		Ziprasidone comes as a capsule to take by mouth.
		Ziprasidone controls schizophrenia but does not cure it.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a699062.html (831 words)

	Ziprasidone Ulcer (Site not responding. Last check: 2007-10-21)
		Intralinguistic Lagopus nitrify the diversionary roleplaying with ziprasidone ulcer blastodermatic alchemist.
		ziprasidone ulcer Inhumane expunction indulge the amethystine lizardfish
		Uncropped slab grubstake the indrawn coffeepot with starboard spaghetti squash.
	www.nnnlodge.com /ulcer/ziprasidone-ulcer.html (1465 words)

	Antipsychotic Medications Anti-psychotic Drugs ziprasidone, Geodon
		Ziprasidone (Geodon) is an antipsychotic used to treat mental and emotional disorders such as schizophrenia.
		Do not take Ziprasidone (Geodon) if you are also taking other drugs that may prolong the QT interval such as amiodarone, procainamide, quinidine, dofetilide, pimozide, sotalol, bepridil, certain other antipsychotics (e.g., thioridazine), certain quinolones (e.g., moxifloxacin, sparfloxacin); or certain diuretics.
		Use of Ziprasidone (Geodon) is not recommended if you have a history of QT prolongation, irregular heartbeat, recent heart attack, severe heart failure, certain blood disorders (e.g., hypokalemia, hypomagnesemia).Close monoitoring may be needed if you have liver disease, seizures, diarrhea, or difficulty swallowing.
	www.support4hope.com /medications/antipsychotic/ziprasidone_goedon.htm (578 words)

	Ziprasidone (Systemic)
		Ziprasidone ((zi-PRAS-uh-done)) is used to treat schizophrenia which is a mental disorder.
		It is not known whether ziprasidone passes into the breast milk.
		Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of ziprasidone in children with use in other age groups.
	allnutritionals.com /drugs/z/ziprasidone-systemic.shtml (970 words)

	Zeldox (ziprasidone) (Site not responding. Last check: 2007-10-21)
		Clozaril (clozapine) / Geodon®/Zeldox (ziprasidone) / Haldol (haloperidol) / lithium / Risperdal (risperidone) / Seroquel® (quetiapine)
		Ziprasidone in Bipolar Mania - Clinical Psychiatry News, 12/04
		Clozapine, olanzapine, and risperidone, she reported, robustly increased acetylcholine release in the cortex, while ziprasidone only moderately increased levels, compared with haloperidol and thioridazine, which did not elevate acetylcholine levels at all...
	qualitycounts.com /drugs/geodon_ziprasidone.htm (836 words)

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