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Topic: Zona fasciculata

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	ENDOCRINE GLANDS
		zona glomerulosa is the thin outermost zone where the cells are arranged as ovoid groups or arching cords.
		zona fasciculata is the thick middle zone in which the cells are arranged in radial cords, 1-2 cells thick.
		zona reticularis is the innermost zone characterized by anastomosing cords of cells.
	www.mc.vanderbilt.edu /histology/labmanual2002/labsection3/AdrenalGlands03.htm (805 words)

	zona fasciculata
		Rat adrenal zona fasciculata cell electrophysiological responses to ACTH and gamma-MSH vary with age.
		The ultrastructure of the aged rat zona fasciculata under various stressing procedures.
		The effects of ageing on the morphology and function of the zonae fasciculata and reticularis of the rat adrenal cortex.
	www.arclab.org /node_pages/1490.html (221 words)

	Adrenal Gland
		The zona glomerulosa is the outer zone lying immediately under the capsule.
		The next layer is the Zona Fasciculata indicated by the fl arrow.
		The blue arrow is pointing to the area underneath of the zona glomerulosa, the Zona Fasciculata.
	www3.umdnj.edu /histsweb/lab22/lab22adrenalgland.html (545 words)

	Endotext.com - Adrenal Physiology And Diseases, Adrenal Cortex, Development, Anatomy, Physiology
		In contrast to the fetal cortex, which is constructed from primarily the zona fetalis, the adult adrenal cortex consists of three anatomically distinct zones (Fig.
		In rats, a fourth zone can further be distinguished, the zona intermedia, between the glomerulosa and the fasciculata currently postulated to be the site of initiation of adrenocyte proliferation and differentiation, ie., the zone containing the adrenal cortical stem cells.
		Zona glomerulosa cells are round and smaller than the polyhedral cells of the zona fasciculata, which gradually extend into the zona reticularis.
	www.endotext.org /adrenal/adrenal1/adrenal1.htm (965 words)

	Home Page
		The zona fasciculata is the middle zone and the largest, constituting about 80% of the cortical volume.
		The transition from the zona fasciculata to zona reticularis is gradual: the cells in the lower part of the ZF are smaller and darker than the spongiocytes.
		In the cortex, the lighter zona fasciculata is bordered by the darker zona glomerulosa and zona reticularis (fairly large in the section shown here).
	courseweb.edteched.uottawa.ca /medicine-histology/English/Endoctrine (4972 words)

	Steroid Hormones
		Zona glomerulosa cells are unique in the adrenal cortex in containing the enzyme responsible for converting corticosterone to aldosterone, the principal and most potent mineralocorticoid.
		The result is that the zona glomerulosa is mainly responsible for the conversion of cholesterol to the weak mineralocorticoid, corticosterone and the principal mineralocorticoid, aldosterone.
		Zona fasciculata and zona reticularis cells also contain the 17-20 lyase, whose activity is responsible for producing the androgens, dehydroepiandosterone and androstenedione.
	dwb.unl.edu /Teacher/NSF/C11/C11Links/web.indstate.edu/thcme/mwking/steroid-hormones.html (1789 words)

	840. Chlorpyrifos-methyl (Pesticide residues in food: 1992 evaluations Part II Toxicology)
		In the females, adrenal zona fasciculata vacuolation was noted in 30/50, 0/50, 0/50, 0/50 and 0/50 as being moderate, and in 19/50, 0/50, 1/50, 2/50 and 2/50 as being slight at 50, 1, 0.1, 0.05 and 0 mg/kg bw/day, respectively.
		At lower doses, percentage incidence of adrenal zona fasciculata vacuolation, consistent with lipid accumulation were, in males, 22%, 18%, 10% and 6% and in females, 0%, 2%, 4% and 4% at 1, 0.1, 0.05 and 0 mg/kg bw/day.
		The incidence of vacuolation of the zona fasciculata at all dose levels except the high dose was within the range of occurrence noted in contemporary rat studies performed in the same laboratory.
	www.inchem.org /documents/jmpr/jmpmono/v92pr06.htm (1270 words)

	Adrenal gland - Wikipedia, the free encyclopedia
		In response to increased potassium levels or decreased blood flow to the kidneys, cells of the zona glomerulosa secrete the mineralocorticoid aldosterone into the blood as part of the renin-angiotensin system.
		Cells of the zona reticularis provide a secondary source of androgens such as testosterone, dihydrotestosterone (DHT), androstenedione, and dehydroepiandrosterone (DHEA).
		These enhance muscle mass, stimulate cell growth, and aid in the development of the secondary sexual characteristics.
	en.wikipedia.org /wiki/Adrenal_gland (892 words)

	Preparation and steroidogenic properties of purified zona fasciculata and zona reticularis cells from the guinea-pig ...
		Preparation and steroidogenic properties of purified zona fasciculata and zona reticularis cells from the guinea-pig adrenal gland -- Hyatt et al.
		Preparation and steroidogenic properties of purified zona fasciculata and zona reticularis cells from the guinea-pig adrenal gland
		Mixtures of zona fasciculata (ZF) and zona reticularis (ZR) cells, obtained by enzyme dispersion of decapsulated guinea-pig adrenal glands, were separated either by unit gravity sedimentation or by equilibrium density sedimentation.
	joe.endocrinology-journals.org /cgi/content/abstract/96/1/1 (322 words)

	Endotext.com - Adrenal Physiology And Diseases, Adrenal Androgens
		The adrenal cortex is divided into three histologic and functional zones: the outer, aldosterone-secreting, called zona glomerulosa; the intermediate, cortisol-secreting, zona fasciculata; and the inner, androgen-secreting zona reticularis.
		Whereas the zona glomerulosa is primarily regulated by angiotensin II, both the zona fasciculata and the zona reticularis are regulated by corticotropin (ACTH) (1).
		The mechanism(s) by which the zona reticularis develops with age and the regulation of adrenarche onset are notunderstood.
	www.endotext.org /adrenal/adrenal3/adrenal3.htm (2678 words)

	Bromocriptine
		The adrenal zona fasciculata-reticularis cells were prepared and incubated with adrenocorticotropic hormone (ACTH), forskolin (an adenylyl cyclase activator), 8-bromo-adenosine 3':5' cyclic monophosphate (8-Br-cAMP, a membrane-permeable analogue of cAMP), and steroidogenic precursors including 25-OH-cholesterol and pregnenolone.
		The corticosterone and pregnenolone release induced by 25-OH-cholesterol in zona fasciculata-reticularis cells was reduced by administration of bromocriptine.
		Administration of bromocriptine in vitro reduced the release of corticosterone stimulated by ACTH and forskolin in rat zona fasciculata-reticularis cells.
	www.thensome.com /stormybrain/Bromocriptine.htm (2974 words)

	Adrenal Histology \| Webpathology.cfm (Site not responding. Last check: 2007-10-21)
		Remarks: Zona reticularis lies deep to zona fasciculata and abuts on the medulla in the head and body of the gland.
		Cells are arranged in anastomosing cords and have acidophilic granular cytoplasm and round vesicular nuclei with punctate nucleoli.
		Zona reticularis is responsible for glucocorticoid and sex hormone synthesis.
	www.webpathology.com /case.cfm?case=78 (157 words)

	Ontogeny of Angiotensin II Type 1 Receptor and Cytochrome P450c11 in the Sheep Adrenal Gland -- Coulter et al. 62 (3): ...
		R-ir was observed predominantly in the zona glomerulosa and
		In D, the thickness of the zona glomerulosa shown is due to the 10-fold increase in size between the term fetal adrenal and adult adrenal gland.
		the zona glomerulosa of the fetal adrenal gland.
	www.biolreprod.org /cgi/content/full/62/3/714 (3606 words)

	Example: Adrenal Cortex (Site not responding. Last check: 2007-10-21)
		The zona glomerulosa is the region immediately under the capsule in which the cells of the cortex are arranged into arcades or arches.
		The cells of the zona fasciculata have a "foamy" appearance in the light microscope, thanks to their very high content of lipid substrate, used as the basis for the manufacture of their principal hormone, the glucocoticoid cortisol (or, in some species, corticosterone).
		The cells of the zona reticularis are similar in appearance to those of the zona fasciculata, but somewhat less "active" looking and electron micrographs show less development of the smooth endoplasmic reticulum than in the zona fasciculata.
	education.vetmed.vt.edu /Curriculum/VM8054/Labs/Lab24/EXAMPLES/EXADCORT.HTM (403 words)

	Environmental Health Perspectives: Irreversible Binding and Adrenocorticolytic Activity of the DDT Metabolite ...
		Labeling of zona glomerulosa, zona reticularis, and the adrenal medulla did not exceed that of the background.
		Labeling of zona glomerulosa and the adrenal medulla did not exceed the background level The radioactivity in these sections remained too weak to be semiquantified by phosphorautoradiography using 14 days exposure.
		Except for a slight swelling of zona fasciculata cells, no obvious histologic changes could be observed after 24 hr of culture of tetracosactide-exposed slices, compared with noncultured slices fixed for histology immediately after slicing (Figure 5 A-B).
	www.findarticles.com /p/articles/mi_m0CYP/is_2_109/ai_77276627/pg_3 (1169 words)

	[No title]
		The cells of the zona fasciculata are the largest of the adrenal cortex.
		The zona reticularis synthesizes weak androgens in the adult adrenal cortex.
		The adrenal cortex is sensitive to ACTH, however, the inner zones, the zona fasciculata and reticularis are primarily affected by ACTH.
	www.kumc.edu /research/medicine/pharmacology/CAI/webCAI/anatomy/to12.wbc (2267 words)

	Virtual Hospital: Atlas of Microscopic Anatomy: Section 1 - Cells (Site not responding. Last check: 2007-10-21)
		The zona glomerulosa synthesizes and secretes mineralocorticoids, primarily aldosterone, which maintains sodium and potassium (electrolyte) and water balance.
		Zona fasciculata, and probably zona reticularis, synthesize and secrete cortisone, cortisol, and glucocorticoids, which are concerned with the regulation of carbohydrate, protein, and fat metabolism.
		Small amounts of androgen and estrogen are also secreted by zona fasciculata and zona reticularis.
	www.vh.org /adult/provider/anatomy/MicroscopicAnatomy/Section15/Plate15293.html (238 words)

	Adrenarche - Wikipedia, the free encyclopedia
		Structural changes of adrenarche include increased size and mass of the adrenal cortex, and completion of differentiation into the three zones: zona glomerulosa, zona fasciculata, and zona reticularis.
		One of the primary functional changes is further differentiation of sex steroid synthesis among the three zones, so that as in adults, the zona glomerlulosa primarily produces mineralocorticoids such as aldosterone, the zona fasciculata primarily produces glucocorticoids such as cortisol, and the zona reticularis primarily produces androgens such as dehydroepiandrosterone, dehydroepiandrosterone sulfate, and androstenedione.
		The second important functional change is a steady increase over several years in the daily production of adrenal androgens.
	en.wikipedia.org /wiki/Adrenarche (679 words)

	Phys. I, Sect. 6, Adrenal Cortex, Syllabi
		Zona fasciculata is the middle and widest layer.
		Conversely, factors that cause increase secretion of cortisol and adrenal androgens and cause hypertophy of the zona’s fasciculata an reticularis have little or no effect on the zona glomerulosa.
		Once ACTH secreted into blood, it has a rapid effect on the inner two layers of the adrenal cortex (especially zona fasciculata) to increase secretion of cortisol.
	www.hodsonhome.com /mna2001/physiology/physiology1/phy1sec6adrenalcortex.htm (1878 words)

	Changes in the glomerulosa cell phenotype during adrenal regeneration in rats -- Engeland and Levay-Young 276 (5): 1374 ...
		zona glomerulosa and an inner zona fasciculata/reticularis (8).
		whereas the synthesis of corticosterone by fasciculata and reticularis
		of regeneration, proliferation is not restricted to the zona intermedia.
	ajpregu.physiology.org /cgi/content/full/276/5/R1374 (4024 words)

	Cytochrome P450-Catalyzed Binding of 3-Methylsulfonyl-DDE and o,p'-DDD in Human Adrenal Zona Fasciculata/Reticularis -- ...
		C]DDE in zona fasciculata and zona reticularis in cultured slices from human adrenal cortex (A, C, E, and G, light-field photographs; B, D, F, and H, dark-field photographs).
		B, A strong labeling of zona reticularis and a marked labeling of zona fasciculata is observed.
		C]DDD in zona fasciculata and zona reticularis in cultured slices from human adrenal cortex (A, C, E, and G, light-field photographs; B, D, F, and H, dark-field photographs).
	jcem.endojournals.org /cgi/content/full/87/3/1319 (3108 words)

	NU570: Digital Library: Microscopic Anatomy Overview (Page 3 of 3) (Site not responding. Last check: 2007-10-21)
		Microscopically, the cortex exhibits three layers or zones: zona glomerulosa (G), zona fasciculata (F), and zona reticularis (R).
		The zona glomerulosa secretes aldosterone, whereas the zona fasciculata and reticularis both secrete glucocorticoids.
		This high magnification view shows characteristic features of the adrenal cortex, including nests of cells in the zona glomerulosa (G) and cords of cells in the zona fasciculata (F).
	jeffline.tju.edu /Education/dl/NU570/library/ma3.html (1239 words)

	Normal Physiology
		The adrenal cortex is composed of an three zones: the zona glomerulosa which produces aldosterone, the middle portion, the zona fasciculata which produces cortisol and androgens, and the inner most layer the zona reticularis, which produces cortisol and androgens.
		The zona fasciculata and reticularis have the enzyme, 17 alpha hydroxylase which is necessary for conversion of precursors to cortisol and androgens.
		is formed in the cells of the zona glomerulosa from cholesterol by converting corticosterone to aldosterone.
	education.vetmed.vt.edu /curriculum/VM8094/gct/Charlie/Physio.html (510 words)

	Lupron vs. Lysodren
		The middle zone is the zona fasciculata (it comprises about 70% of the cortex), and it secretes the glucocorticoid hormones (mainly cortisol).
		It works by destroying the cortisol producing cells (zona fasciculata) and some of the cells in the zona reticularis.
		In a histopath (biopsy) study in dogs, the zona fasciculata was destroyed in the hyperplasia group, but the tumor group contained a clear description of the tumor histology.
	www.miamiferret.org /fhc/murray.htm (1185 words)

	Irreversible Binding and Adrenocorticolytic Activity of the DDT Metabolite 3-Methylsulfonyl-DDE Examined in ...
		C]DDE binding was confined to zona fasciculata in mouse adrenal slices, demonstrated by bright-field (A) and corresponding dark-field (B) images.
		A slight swelling of zona fasciculata cells could be observed after 24 hr, as compared with noncultured slices.
		Notably, the mitochondrial membranes are largely intact in zona glomerulosa (C) and zona fasciculata (D).
	ehp.niehs.nih.gov /members/2001/109p105-110lindhe/lindhe-full.html (4916 words)

	Differential Gene Expression of Cytochrome P450 11{beta}-Hydroxylase in Rat Adrenal Cortex after in Vivo Activation -- ...
		Using the generic P45011ß probe (A and C), labeling is present in the zona glomerulosa (zg), the zona fasciculata/reticularis (zf), and a few clusters of cells in the medulla (med), but is absent in the zona intermedia (zi).
		in the outer fasciculata and increased in the zona reticularis
		the zona fasciculata to expand outward at the expense of the
	endo.endojournals.org /cgi/content/full/138/6/2338 (5005 words)

	Hormone-Sensitive Lipase Deficiency in Mice Causes Lipid Storage in the Adrenal Cortex and Impaired Corticosterone ...
		A, Zona glomerulosa from control adrenal gland, B, Zona fasciculata cells from control adrenal gland.
		D, Internal portion of zona fasciculata in which cells are characterized by a heterogeneous population of lipid droplets of various sizes (fl arrows) and formation of SLS (white arrow).
		from the outer to the inner regions of the zona fasciculata
	endo.endojournals.org /cgi/content/full/143/9/3333 (4443 words)

	Steroid Hormones
		Zona glomerulosa cells lack the P450c17 that converts pregnenolone and progesterone to their C
		Cells of the zona fasciculata and zona reticularis lack aldosterone synthase (P450c18) that converts corticosterone to aldosterone, and thus these tissues produce only the weak mineralocorticoid corticosterone.
		Zona fasciculata and zona reticularis cells also contain the C17,20 lyase, whose activity is responsible for producing the androgens, dehydroepiandosterone (DHEA) and androstenedione.
	www.indstate.edu /thcme/mwking/steroid-hormones.html (2439 words)

	The Adrenal Glands
		The outer covering (adrenal cortex) is derived from the fetal mesodermal ridge, a structure that also gives rise to the kidneys so that the juxtaposition of the two organs is not surprising.
		Within the adrenal cortex are three zones known as the outer (zona glomerulosa), the middle (zona fasciculata), and the inner (zona reticularis).
		The adrenal cortex is capable of synthesizing all of the steroid hormones produced by the body, including the progestogens and estrogens (see the ovary), androgens (see the testis), mineralocorticoids (which are secreted from the zona glomerulosa), and glucocorticoids (which are synthesized and released from the zona fasciculata and zona reticularis of the adrenal cortex).
	www.becomehealthynow.com /article/bodyendocrine/679 (1377 words)

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