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Topic: Atypical antipsychotic

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In the News (Wed 21 Aug 19)

  FDA Public Health Advisory: Deaths with Antipsychotics in Elderly Patients with Behavioral Disturbances
The atypical antipsychotics fall into three drug classes based on their chemical structure.
Because the increase in mortality was seen with atypical antipsychotic medications in all three chemical classes, the Agency has concluded that the effect is probably related to the common pharmacologic effects of all atypical antipsychotic medications, including those that have not been systematically studied in the dementia population.
All of tvhe atypical antipsychotics are approved for the treatment of schizophrenia.
www.fda.gov /cder/drug/advisory/antipsychotics.htm   (338 words)

  Atypical antipsychotic - Wikipedia, the free encyclopedia
All atypical antipsychotics are FDA approved for use in the treatment of schizophrenia.
The first atypical antipsychotic medication, clozapine, was discovered in the 1950s, and introduced in clinical practice in the 1970s.
The atypical antipsychotics have found favor among clinicians and are now considered to be first line treatments for schizophrenia and are gradually replacing the typical antipsychotics.
en.wikipedia.org /wiki/Atypical_antipsychotic   (1056 words)

 Antipsychotic - Wikipedia, the free encyclopedia
Antipsychotics also have some effects as mood stabilizers, leading to their frequent use in treating mood disorder (particularly bipolar disorder) even when no signs of psychosis are present.
Typical antipsychotics are not particularly selective and also block the same receptors in the mesocortical pathway, tuberoinfundibular pathway and the nigrostriatal pathway.
The newer atypical antipsychotics are supposedly rationally designed drugs in which a theoretical understanding of both the condition to be treated and the effect of certain molecules on the body is used to develop potential new drug candidates.
en.wikipedia.org /wiki/Antipsychotic   (1708 words)

 Antipsychotic Drugs, Atypical | AHealthyMe.com
The atypical antipsychotic agents, sometimes called the "novel" antipsychotic agents are a group of drugs which are different chemically from the older drugs used to treat psychosis.
The "conventional" antipsychotic drugs are classified by their chemical structures as the phenothiazines, thioxanthines (which are chemically very similar to the phenothiazines), butyrophenones, diphenylbutylpiperadines and the indolones.
Atypical antipsychotics should not be used in patients with liver damage, brain or circulatory problems, or some types of blood problems.
www.ahealthyme.com /topic/topic103548614   (880 words)

 Atypical Antipsychotic Medications For Treating Schizophrenia
Antipsychotic drug treatment for Schizophrenia is usually continuous, as relapse of symptoms is common when medication is discontinued.
Antipsychotics or neuroleptic drugs (as they're sometimes called) help relieve the positive symptoms of schizophrenia by helping to correct an imbalance in the chemicals that enable brain cells to communicate with each other.
Compared to the older "conventional" antipsychotics these medications appear to be equally effective for helping reduce the positive symptoms like hallucinations and delusions - but may be better than the older medications at relieving the negative symptoms of the illness, such as withdrawal, thinking problems, and lack of energy.
www.healthyplace.com /Communities/Thought_Disorders/schizo/medications   (418 words)

 NAMI | Schizophrenia
Compared to the older "conventional" antipsychotics these medications appear to be at least equally effective for helping reduce the positive symptoms like hallucinations and delusions - but may be better than the older medications at relieving the negative symptoms of the illness, such as withdrawal, thinking problems, and lack of energy.
Clozapine was the first atypical antipsychotic in the United States and seems to be one of the most effective medications, particularly for people who have not responded well to other medications.
For this reason clozapine is usually the last atypical antipsychotic prescribed, and is usually used as a last line treatment for people that do not respond well to other medications or have frequent relapses.
www.nami.org /Template.cfm?Section=By_Illness&template=/ContentManagement/ContentDisplay.cfm&ContentID=7416   (1528 words)

 Atypical Antipsychotics: Their Emerging Role in the Treatment of Early-Onset Bipolar Disorder   (Site not responding. Last check: )
The atypicals may benefit children who have prolonged rage attacks, psychotic symptoms, mixed-irritable moods, and possibly very rapid cycling of mood--all of which are relatively commonly associated with early-onset bipolar disorder and may require different forms of treatment than are usual in adults.
The popularity of the newer atypical antipsychotics for childhood bipolar disorder patients is growing rapidly, and we have now heard of a number of cases where these drugs are prescribed alone, as the major, or only treatment offered.
This advantage appears to include the newer atypical antipsychotics, although they are limited in not being available in injectable forms, and by their sometimes limited tolerability when administrated in initially high doses.
www.bipolarchild.com /newsletters/0010.html   (4104 words)

 Current Medicinal Chemistry, Volume 11, No. 3, 2004
The development of new "atypical" antipsychotic agents, which are safer than classical neuroleptics and also active against the negative symptoms and neurocognitive deficits caused by the illness, has produced a significant advancement in the treatment of schizophrenia.
Hence, the initial excitement since the introduction of atypical antipsychotics in late 1980s is now shifting towards a focus on individualization of pharmacotherapy and elucidation of the mechanistic basis of interindividual variability in drug response with use of pharmacokinetic and pharmacodynamic biomarkers.
The aim of this paper is to review literature about newer antipsychotics, focusing on their advantages in terms of efficacy and side effect profiles when compared to classical and older atypical antipsychotics, and to evaluate the efficacy of the different new antipsychotics when compared to one another.
www.bentham.org /cmc/contabs/cmc11-3.htm   (1776 words)

 New Drugs
The so-called "new generation" or "atypical" antipsychotic medications have actually become the typical medications prescribed by psychiatrists today in the treatment of schizophrenia and other psychotic disorders.
Moreover, the atypicals, also as a result of this receptor function, may reduce the severity of "negative" symptoms of schizophrenia, such as apathy in personal care and interests, social withdrawal, and flattening of emotions.
There is no question that the old antipsychotic drugs have their shortcomings, particularly regarding the tolerance issue; and we psychiatrists all eagerly await a better mouse trap; but I simply don't believe we're there yet.
doctorz.home.mindspring.com /id14.html   (927 words)

 Atypical Antipsychotic Drugs
Other atypical antipsychotic drugs have not been as well studied as clozapine, but there is enough evidence of their relationship to clozapine and of clinically important differences between them and neuroleptics to warrant the new designation.
Common to all definitions of atypical antipsychotic drugs of which I am aware is the ability to produce an antipsychotic action in most patients at doses that do not cause significant acute or subacute extrapyramidal side effects (EPS), such as parkinsonism and akathisia.
The differences in clinical profile among atypical antipsychotics identified solely on the basis of low EPS suggests that multiple biological mechanisms may be responsible for the diverse differences between clozapine and typical antipsychotic drugs.
www.acnp.org /g4/GN401000123/CH121.html   (5915 words)

 Comparison of Cognitive Performances During a Placebo Period and an Atypical Antipsychotic Treatment Period in ...
During one phase, patients were administered atypical antipsychotics: four received risperidone, three received clozapine, two received clozapine and risperidone, one received quetiapine fumarate, one received quetiapine fumarate and olanzapine, seven received olanzapine, and one received olanzapine and risperidone.
Cognitive improvement with administration of atypical antipsychotics did not appear to be driven by those patients receiving clozapine therapy since most significant differences obtained for specific assessments still remained significant after exclusion of those patients receiving clozapine, thereby maintaining significant differences even with a reduction in sample size (data available upon request).
By comparing atypical antipsychotic to placebo the effects of atypicals can be assessed relative to the disease state as opposed to a deficit state induced by typical neuroleptics.
www.nature.com /npp/journal/v28/n8/full/1300216a.html   (5338 words)

 Perspectives in Psychiatric Care: Metabolic Effects Associated With Atypical Antipsychotic Medications   (Site not responding. Last check: )
Additional hypotheses point to the activity of atypical antipsychotic medication at the serotonin receptors of the beta cells in the pancreas, notably 5HT^sup 1A^ and 5HT^sub 2^ receptors; however, their roles appear complex.
Speculations about the rise in triglycerides and total cholesterol levels suggest that some atypical antipsychotic medications (e.g., olanzapine, clozapine) may increase serum LDL and triglyceride levels and lower high -density lipoprotein (HDL) cholesterol, which may be independent of weight gain (Wirshing et al, 2002).
Prior to prescribing an atypical antipsychotic medication, it is incumbent on the prescribing psychiatric nurse to perform a thorough psychiatric and medical history of the patient's current medical problems and history (e.g., diabetes, CVD), including family history, measures of weight, height, and adiposity, and to monitor these over time.
www.findarticles.com /p/articles/mi_qa3804/is_200404/ai_n9401763   (1287 words)

 Antipsychotic drug - nuvunow.ca
The term antipsychotic is applied to a group of drugs commonly but not exclusively used to treat psychosis.
Antipsychotic drugs are the best treatment now available, but they do not cure schizophrenia or ensure that there will be no further psychotic episodes.
The atypical antipsychotic agents, sometimes called the "novel" antipsychotic agents are a group of drugs which are different chemically from the older drugs used to...
www.nuvunow.ca   (203 words)

 Antipsychotics & Diabetes
Since they arrived on the market in the 1990s, the so-called 'atypicial' antipsychotic drugs have been wrapped in controversy and promotional hype by drug companies and their paid professional spin masters who made bald claims about their "favorable side effect profile" referring to them as "breakthrough" "miracle" drugs that "balance the chemistry" in the brain.
In 1994, a Duke team first reported a Diabetes link to the first 'atypical' antipsychotic drug, clozapine: last year, 384 reports of diabetes last year were associated with clozapine.
In the under-40 age group, 8.75% of those receiving atypical antipsychotics and 6.43% of those treated with typical agents were diagnosed with diabetes (p = 0.007), and for those between 50 and 59 years of age, the prevalence in the two groups was 22.73% versus 20.56% (p = 0.003).
www.namiscc.org /Research/2002/Diabetes.htm   (2190 words)

 The Putative Atypical Antipsychotic Drug Amperozide Preferentially Increases c-fos Expression in Rat Medial Prefrontal ...
However, the index of atypicality calculated as the difference between the number of neurons displaying FLI in the NAcc and the dorsolateral striatum was positive for both doses, indicating that by this criterion amperozide can be classified as an atypical antipsychotic drug.
Marcus MM, Nomikos GG, Svensson TH (1996): Differential actions of typical and atypical antipsychotic drugs on dopamine release in the core and shell of the nucleus accumbens.
Robertson GS, Matsubura H, Fibiger HC (1994): Induction patterns of Fos-like immunoreactivity in the forebrain as predictors of atypical antipsychotic activity.
www.nature.com /npp/journal/v17/n3/full/1395022a.html   (2519 words)

 Inverse Agonist Actions of Typical and Atypical Antipsychotic Drugs at the Human 5-Hydroxytryptamine2C Receptor -- ...
Atypical antipsychotic drugs, which are distinguished from typical antipsychotic drugs by a lower incidence of extra-pyramidal
Borison RL, Arvanitis LA and Miller BG (1986) ICI 204,636, an atypical antipsychotic: efficacy and safety in a multicenter, placebo-controlled trial in patients with schizophrenia.
Brown LA and Levin GM (1998) Sertindole, a new atypical antipsychotic for the treatment of schizophrenia.
jpet.aspetjournals.org /cgi/content/full/299/1/83   (4174 words)

 Inverse Agonist Activity of Atypical Antipsychotic Drugs at Human 5-Hydroxytryptamine2C Receptors -- Herrick-Davis et ...
The mechanisms responsible for the superior clinical effects of atypical antipsychotic drugs such as clozapine are not known.
Atypical antipsychotics have been reported to be more effective in treating the negative symptoms of schizophrenia and improving
Moghaddam B and Bunney BS (1990) Acute effects of typical and atypical antipsychotic drugs on the release of dopamine from prefrontal cortex, nucleus accumbens, and striatum of the rat: An in vivo microdialysis study.
jpet.aspetjournals.org /cgi/content/full/295/1/226   (4533 words)

 Mechanism Of Action Of Atypical Antipsychotic Agents   (Site not responding. Last check: )
Atypical antipsychotic drugs are agents that are antipsychotic at doses that do not produce extrapyramidal symptoms.
In effect, the single most powerful predictor of atypicality for the current generation of atypical antipsychotics is fast dissociation from the D2 receptor, and not high affinity at 5-HT2, D4, or other receptor sites.
In contrast to the multi receptor hypotheses, this hypothesis suggests that the atypical antipsychotic effect can be produced by appropriate modulation of the D2 receptor alone; the blockade of other receptors is neither necessary nor sufficient for atypicality.
www.indegene.com /Psy/Jour/indJour_AJP_Sum_01-03-2001_1.asp   (287 words)

 Zyprexa Olanzapine side effects drug warnings news lawyer lawsuit info
Zyprexa is an atypical antipsychotic prescription medication used to help manage symptoms of schizophrenia, the manic phase of manic-depression, and other psychotic disorders.
Unfortunately, atypical antipsychotic drugs like Zyprexa have been shown to complicate the metabolism in some users, leading to serious blood sugar disorders like hyperglycemia and pancreatitis.
Atypical antipsychotic drugs were heralded from the onset because they differed from first generation antipsychotics by blocking certain neurochemical reactions within the brain, effectively alleviating the drug's negative aspects.
www.resource4zyprexainfo.com   (1214 words)

 Older Antipsychotic Drugs Called Risky Compared With Atypical Agents - CME Teaching Brief - MedPage Today
Be aware that both atypical and older antipsychotic drugs appear to have risks for elderly patients and should be prescribed with caution.
The finding comes in the wake of a "fl box" warning from the FDA earlier this year that the atypical agents -- such as Zyprexa (olanzapine) and Risperdal (risperidone) -- were associated with increased mortality in elderly patients with dementia.
Overall, the use of any conventional antipsychotic was associated with a relative risk of mortality of 1.37 (with a 95% confidence interval from 1.27 to 1.49) compared to atypical agents.
www.medpagetoday.com /Psychiatry/GeneralPsychiatry/tb/2243   (769 words)

 Atypical antipsychotic
All atypical antipsychotics are FDA approved for use in the treatment of
The atypical antipsychotics have found favor among clinicians and are now considered to be first line treatments for schizophrenia and are gradually replacing the
It must also be pointed out that although all atypicals must carry the warning on their labeling, some evidence shows that all atypicals are not equal in their effects of weight and
www.bipolarworld.net /Medications/Antipsychotics/antipsy7.htm   (633 words)

 Newer atypical antipsychotic medication versus clozapine for schizophrenia (Cochrane Review)   (Site not responding. Last check: )
Background: Clozapine is an atypical antipsychotic drug, which is claimed to have superior efficacy and to cause fewer movement disorders.
Newer atypical antipsychotics are safer alternatives that might share the benefits of clozapine.
It is thus of interest to compare the effectiveness of newer atypical antipsychotics with the effectiveness of clozapine.
www.cochrane.org /cochrane/revabstr/ab000966.htm   (490 words)

 Focus on Risperidone - an atypical antipsychotic manufactured by Janssen
It is a novel antipsychotic with dopaminergic and serotonergic effects.
In one evaluation, compared to haloperidol, a conventional antipsychotic, risperidone-treated patients obtained more than twice as many quality-adjusted years as haloperidol patients and in addition risperidone was found to be cost-effective, (Chouinard and Albright, 1997).
Risperidone is one of a new generation of antipsychotic drugs with relatively fewer side effects and equal efficacy for florid 'positive' symptoms.
www.priory.com /focus9.htm   (3401 words)

 News - Atypical Antipsychotic Drugs Effective for Elderly Patients with Dementia
Knowledgeable administration of atypical antipsychotic drugs can improve quality of life in elderly patients with dementia and behaviour disturbances, according to a recent review of this type of treatment.
Antipsychotic medications can be prescribed to treat these symptoms; however these drugs can be somewhat less familiar to family physicians.
Haloperidol (Haldol) is a typical antipsychotic drug that has been administered to patients experiencing psychotic and behaviour disturbances.
www.docguide.com /news/content.nsf/news/8525697700573E1885256D3C004A9F0F   (547 words)

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