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Topic: Cannabinol

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Cannabidiol

Tetrahydrocannabivarin

Cannibus

Cannabinoids

Tetrahydrocannabinol

Cannabis

Marijuana

Tetrahydrocannabinol

THC

Inorganic table information

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	Delta 9-Tetrahydrocannabinol and Cannabinol Activate Capsaicin-Sensitive Sensory Nerves via a CB1 and CB2 Cannabinoid ...
		The vasodilator action of THC and cannabinol is not mimicked by C11 hydroxy and carboxy derivatives of THC.
		Effects of CB and vanilloid receptor antagonists on sensory nerve-mediated relaxation induced by THC, cannabinol, and anandamide in rat hepatic and mesenteric arteries.
		evoked by THC and cannabinol in hepatic arteries (Fig.
	www.jneurosci.org /cgi/content/full/22/11/4720 (5122 words)

	Old Medicine with New Promise For Neurological Disorders
		Other major plant cannabinoids include cannabidiol and cannabinol, both of which may modify the pharmacology of THC and have distinct effects of their own.
		Much less is known about cannabinol, although it appears to have pharmacological properties that are quite different from cannabidiol.
		Cannabinol has significant anticonvulsant, sedative and other pharmacological activities likely to interact with the effects of THC [14].
	www.med-cannabis.com (4335 words)

	THE HERB DANGEROUS
		Cannabinol when taken internally induces delirium and sleep, and, as far as at present known, is the intoxicating constituent of Indian hemp.
		The active principle Cannabinol (as far as is known) rapidly oxidises and loses its properties so that if a really active preparation is required, it is best to get it made in India, using absolute alcohol and the fresh tops, or recently made charas, which, being a solid mass, does not readily oxidise.
		The volatile fatty acids produced on oxidising Cannabinol by nitric acid are shown to be normal butyric (Dunstan and Henry, Proc.
	www.the-equinox.org /vol1/no1/eqi01015.html (4972 words)

	Director's Report 5/00 - Basic Research
		Moreover, electrophoretic mobility shift assays demonstrated that cannabinol markedly inhibited the DNA binding activity of nuclear factor of activated T-cells (NF-AT) and activator protein-1 (AP-1) in a time- and concentration-dependent manner in activated EL4 cells.
		The inhibitory effects produced by cannabinol on AP-1 DNA binding were quite transient, showing partial recovery by 240 min after cell activation and no effect on the activity of a reporter gene under the control of AP-1.
		Collectively, these results suggest that decreased IL-2 production by cannabinol in EL4 cells is due to the inhibition of transcriptional activation of the IL-2 gene and is mediated, at least in part, through a transient inhibition of AP-1 and a sustained inhibition of NF-AT.
	www.nida.nih.gov /DirReports/DirRep500/DirectorReport1.html (3495 words)

	Statement of Dr. A. H. Blatt
		Cannabinol, again was secured for the second time, and apparently it can be repeated.
		Pure Cannabinol is the fourth chemical substance to be gotten out of Cannabis, and it is the fourth one to be lacking in narcotic activity.
		It is toxic, however, and it is quite possible that some of the activity of Cannabinol, some of this complex activity that has been referred to during the morning, is due to pure Cannabinol as a chemical individual.
	www.druglibrary.org /schaffer/hemp/taxact/mhc9.htm (0 words)

	cannabinol (Site not responding. Last check: )
		Dopamine Dopamine is a neurotransmitter that is derived cannabinol from the amino acid tyrosine, and cannabinol is structurally related to norepinephrine.
		Some departments have mandated cannabinol side effects that one team must be at home to ensure that if another csannabinol team is quarantined because of exposure, there will cannabinol side effects still be a clean team available to continue emergency work (Mukherjee).
		Although cannabinol side effects no informa tion is available on the effects in infants, the manufacturer recommends that aman tadine be used cautiously in annabinol nursing annabinol mothers.
	cannabinol.sbko.info (6228 words)

	cannabinol - OneLook Dictionary Search
		Tip: Click on the first link on a line below to go directly to a page where "cannabinol" is defined.
		cannabinol : Dorland's Illustrated Medical Dictionary [home, info]
		Cannabinol : Street Terms: Drugs and the Drug Trade [home, info]
	www.onelook.com /?w=cannabinol (126 words)

	Volcano Vaporizer Study
		The new study used a gas chromatograph mass spectrometer (GCMS) to examine the gas components of the vapor.
		Two other cannabinoids, cannabidiol (CBD) and cannabinol (CBN), were detected in the NIDA cannabis in trace amounts of 0.1%.
		Both the Volcano® and combustion delivered an apparent increase in CBD and CBN, but the variance of the data was too high to reach statistically significant conclusions.
	www.canorml.org /healthfacts/vaporizerstudy2.html (802 words)

	UNODC - Bulletin on Narcotics - 1959 Issue 4 - 002
		As a result of our research work on varieties of hemp grown for seed in the Northern Caucasus, it was established that their resinous secretions gave positive results with cannabinol compound reagents, but at the same time they did not have the physiological effect peculiar to the resin of Indian hemp ([ 7]).
		Resinous secretions of hemp grown for seed in the central districts of the European part of the USSR, as well as of the variety of hemp grown for seed in the Northern Caucasus, are pharmacologically inactive.
		As the cannabinol reactions are not specific for the narcotic substances of hemp, it is necessary in the forensicchemical expertise of hemp preparations to carry out these reactions in conjunction with biological evaluation.
	www.unodc.org /unodc/en/bulletin/bulletin_1959-01-01_4_page003.html (2469 words)

	Cannabinoids - Wikipedia, the free encyclopedia
		All classes derive from cannabigerol-type compounds and differ mainly in the way this precursor is cyclized.
		Tetrahydrocannabinol (THC), cannabidiol (CBD) and cannabinol (CBN) are the most prevalent natural cannabinoids and have received the most study.
		Cannabinol (CBN), a degradation product of THC, produces a depressant effect
	en.wikipedia.org /wiki/Cannabinoids (2237 words)

	Student Resources: Student Projects - Akinde Omotayo (Site not responding. Last check: )
		Cannabinol, also known as CBD, is a non-psychoactive cannabinoid in the hemp plant Cannabis sativa.
		Cannabinol content increases as THC degrades in storage and with exposure to light and air.
		Cannabinol extraction from its crude form - cannabis is quite similar to extraction mechanisms discussed earlier in this paper.
	lib1.bmcc.cuny.edu /studres/projectsakinde.html (2695 words)

	Cannabinoid Inhibition of Adenylate Cyclase-mediated Signal Transduction and Interleukin 2 (IL-2) Expression in the ... (Site not responding. Last check: )
		However, stimulation of cells with forskolin in the presence of cannabinol resulted in a noticeably diminished magnitude of CRE binding at all time points assayed after 30 min.
		This subline of EL4.IL-2 cells produces an average of 2500 units/ml of murine IL-2 when stimulated with PMA for 24 h which is indistinguishable from normal, concanavalin A-stimulated spleen cells, having the same molecular weight and isoelectric point heterogeneity (27).
		This is not completely unexpected in light of the fact that CREB has been shown to form heterodimers with both Fos and Jun proteins (42, 43).
	www.jbc.org /cgi/content/full/271/22/13175 (7996 words)

	Evidence for Cannabinoid Receptor-Dependent and -Independent Mechanisms of Action in Leukocytes -- Kaplan et al. 306 ... (Site not responding. Last check: )
		Cannabinol (CBN), ionomycin (Io), and thapsigargin (TG) elevate intracellular calcium concentration in resting splenocytes.
		Cannabinol (A), ionomycin (B), or thapsigargin (C) was added by glass syringe to the cuvette at either 50 or 300 s and the increase in intracellular calcium concentration was measured for 1,800 s total.
		The calcium response induced by cannabinol was drastically
	jpet.aspetjournals.org /cgi/content/full/306/3/1077 (5146 words)

	BioMed Central \| Full text \| Heterogeneity of human adipose blood flow
		The ability of the same PBPK model to describe both the anesthetic and cannabinol kinetics provides direct qualitative evidence that their kinetics are flow limited and that there is no significant adipose tissue diffusion limitation.
		The data and experimental methodology is described in the cannabinol [20] and cannabidiol [21] publications.
		For example, at 20 days, the residual blood cannabinol concentration for the N = 3 adipose model is about 10 times higher than for the N = 1 model and 100 times higher than the one compartment model, and this difference grows exponentially with time (fig.
	www.biomedcentral.com /1472-6904/7/1 (7425 words)

	It:Tetrahydrocannabinol - ChemWiki
		Tetrahydrocannabinol undergoes oxidation to either cannabinol or 9,10-dihydroxy-tetrahydrocannabinol.
		Cannabinol (CBN) is also the natural degradation (oxidative) product of THC.
		Fresh samples of marijuana contain very little CBN but curing, or poor storage, over long periods can cause much of the THC to be oxidized to CBN.
	www.ch.ic.ac.uk /wiki/index.php/It:Tetrahydrocannabinol (571 words)

	Bulletin of the New York Academy of Medicine 1942 on Marijauna, "5 Stars" A indepth Report With Lots of diagrams. (Site not responding. Last check: )
		Cahn's proposed formula for cannabinol is shown; his evidence for this structure was conclusive except for the positions of the hydroxyl and n-amyl groups.
		The complicated and extensive chemical investigations on the structure of cannabidiol, on the synthesis of cannabinol, and on the preparation of tetrahydrocannabinol and synthetic analogs, will be presented in very brief form and.
		Cannabinol was shown to contain the linkage between the hydroxyls by synthesis of this molecule by an unequivocal method.
	www.onlinepot.org /reefermadness/nybulletin1942.htm (7354 words)

	The State of Medical Marijuana in Washington : Medical Cannabis: Rational Guidelines for Dosing
		Delta-9 THC, the active ingredient in dronabinol (Marinol) is the most abundant cannabinoid in the plant and this has led researchers to hypothesize that it is the main source of the drug's impact.[15] Dronabinol is available by prescription as a schedule III drug.
		Other major plant cannabinoids include cannabidiol and cannabinol, both of which may modify the pharmacology of THC and have distinct effects of their own.
		Cannabidiol breaks down to cannabinol as the plant matures.[15] Much less is known about cannabinol, although it appears to have distinct pharmacological properties that are quite different from cannabidiol.
	cannabismd.org /foundation/mmjdosingguidelines.php (3505 words)

	[No title] (Site not responding. Last check: )
		Comparisons with Chemical Standards To determine which peaks in the chromatograms were actually Cannabinol and THC, chemical standards were purchased from Sigma Chemical Co. and used to calibrate the SAW/GC.
		A chromatogram of the Cannabinol standard with the THC standard chromatogram overlaid in the background is shown in REF _Ref378610023 \* MERGEFORMAT Figure 12.
		Note that THC vapors are not detected, however, cannabinol vapors are detected and in this sample.
	www.diagnoze.com /applications/AppnoteMarijuanna-zNose.doc (3360 words)

	Nabilone: a potent antiemetic cannabinol with minimal euphoria.
		Nabilone: a potent antiemetic cannabinol with minimal euphoria.
		Herman TS; Jones SE; Dean J; Leigh S; Dorr R; Moon TE; Salmon SE Nabilone is a cannabinol derivative which has potent central antiemetic effects in animals.
		We observed that the drug significantly reduced the nausea and vomiting induced by cancer chemotherapy in 10 of 13 patients who were refractory to conventional antiemetics.
	www.medscape.com /medline/abstract/606307 (171 words)

	Cannabinol
		The word "cannabinol" uses 10 letters: A A B C I L N N N O.
		Words within cannabinol not shown as it has more than seven letters.
		List all words starting with cannabinol, words containing cannabinol or words ending with cannabinol
	www.morewords.com /word/cannabinol (192 words)

	Definition of cannabinol - Merriam-Webster Online Dictionary
		Learn more about "cannabinol" and related topics at Britannica.com
		Find more about "cannabinol" instantly with Live Search
		See a map of "cannabinol" in the Visual Thesaurus
	www.m-w.com /cgi-bin/dictionary?book=Dictionary&va=cannabinols (26 words)

	Role of mitogen-activated protein kinases in the differential regulation of interleukin-2 by cannabinol -- Jan and ... (Site not responding. Last check: )
		Role of mitogen-activated protein kinases in the differential regulation of interleukin-2 by cannabinol -- Jan and Kaminski 69 (5): 841 -- Journal of Leukocyte Biology
		Role of mitogen-activated protein kinases in the differential regulation of interleukin-2 by cannabinol
		Faubert, B., Kaminski, N. (2000) AP-1 activity is negatively regulated by cannabinol through inhibition of its protein components, c-fos and c-jun J.
	www.jleukbio.org /cgi/content/full/69/5/841 (5152 words)

	The State of Medical Marijuana in Washington : Medical Cannabis: Rational Guidelines for Dosing (Site not responding. Last check: )
		Delta-9 THC, the active ingredient in dronabinol (Marinol) is the most abundant cannabinoid in the plant and this has led researchers to hypothesize that it is the main source of the drug's impact.[15] Dronabinol is available by prescription as a schedule III drug.
		Other major plant cannabinoids include cannabidiol and cannabinol, both of which may modify the pharmacology of THC and have distinct effects of their own.
		Cannabidiol breaks down to cannabinol as the plant matures.[15] Much less is known about cannabinol, although it appears to have distinct pharmacological properties that are quite different from cannabidiol.
	www.cannabismd.org /foundation/mmjdosingguidelines.php (3505 words)

	Lycaeum > Leda > Preliminary report on the separation and quantitative determination of cannabis constituents ... (Site not responding. Last check: )
		The same sample was negative for Δ-6-THC (less than 0.001%) and positive for cannabinol, cannabidiolic acid, olivetol and other unidentified compounds.
		Liquid-liquid extraction of compounds from urine and determination by gas liquid chromatography was accomplished using an internal standard response ratio developed from fortified urines carried through every step of the procedure.
		In one set of experiments urine was fortified with various graded quantities of cannabis resin and carried through the procedure described.
	leda.lycaeum.org /?ID=16615 (1696 words)

	Natural products: Leads for new pharmaceuticals - Editorial - Express Pharma Pulse
		The measured dose of Cannabinol dissolved in sesame oil and administered in gelatin capsule.
		The multiplicity of effects of cannabinol have led to the synthesis of large number of analogs, particularly non-morphine, like analgesics without addictiveness and without the other CNS effects of cannabinol.
		The recent ‘cannabinol receptor’ is anandamine, a little obvious structural similarity between cannabinol and anandamide, opening up new areas for research into analogs of the latter which may achieve the ultimate goal of separation of all the mixed effects of cannabinol.
	www.expresspharmapulse.com /20030130/edit2.shtml (1035 words)

	Director's Report 5/00 - Basic Research
		Moreover, electrophoretic mobility shift assays demonstrated that cannabinol markedly inhibited the DNA binding activity of nuclear factor of activated T-cells (NF-AT) and activator protein-1 (AP-1) in a time- and concentration-dependent manner in activated EL4 cells.
		The inhibitory effects produced by cannabinol on AP-1 DNA binding were quite transient, showing partial recovery by 240 min after cell activation and no effect on the activity of a reporter gene under the control of AP-1.
		Collectively, these results suggest that decreased IL-2 production by cannabinol in EL4 cells is due to the inhibition of transcriptional activation of the IL-2 gene and is mediated, at least in part, through a transient inhibition of AP-1 and a sustained inhibition of NF-AT.
	www.drugabuse.gov /DirReports/DirRep500/DirectorReport1.html (3495 words)

	VooDoo Digital Volcano Vaporizers, Vapir at PYRO Products INC
		The analysis showed that the Volcano® vapor was remarkably clean, consisting 95% of THC with traces of cannabinol (CBN), another cannabinoid.
		Two other cannabinoids, cannabidiol (CBD) and cannabinol (CBN), were detected in the NIDA cannabis in trace amounts of 0.1%.
		Both the Volcano® and combustion delivered an apparent increase in CBD and CBN, but the variance of the data was too high to reach statistically significant conclusions.
	www.pyro-products.com (1599 words)

	Role of Nuclear Factor of Activated T-Cells and Activator Protein-1 in the Inhibition of Interleukin-2 Gene ... (Site not responding. Last check: )
		One notable exception is cannabinol (CBN), a plant-derived cannabinoid
		Time-Dependent Effects of Cannabinol on NF-AT, AP-1, and Oct Binding Activity.
		Concentration-Dependent Effects of Cannabinol on NF-AT, AP-1, and Oct Binding Activity.
	jpet.aspetjournals.org /cgi/content/full/292/2/597 (5637 words)

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