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Topic: Cyclamate

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	Cyclamate
		Cyclamate was initially marketed as tablets that were recommended for use as a tabletop sweetener for diabetics.
		In 1969, the result of a chronic toxicity study with a mixture of cyclamate and saccharin was interpreted as implicating cyclamate as a bladder carcinogen in rats.
		Cyclamate was removed from GRAS status and eventually in 1970 banned in the United States from use in foods, beverages and drugs, and is still currently banned.
	www.elmhurst.edu /~chm/vchembook/549cyclamate.html (339 words)

	Cyclamate (Site not responding. Last check: )
		Abbott zamýšlel používat cyclamate, aby maskoval nepřátelství jistých drog takový jako antibiotika a pentobarbital.
		Cyclamate je vápník nebo sodíková sůl kyseliny cyclamic (cyclohexanesulfamic kyselinu) (cyclohexylsulfamate vápníku a sodík cyclohexylsulfamate).
		Cyclamate je ještě používán jako sladidla v mnoha jiných částech světa a to je schváleno v přes 55 zemí.
	www.wikipedia.infostar.cz /c/cy/cyclamate.html (275 words)

	Cyclamate
		The production of Sodium and Calcium Cyclamate includes the reaction of cyclohexylamine with sulfamic acid, salt determination, isolation, filtration, re-crystallization and then drying.
		Cyclamate is 20 to 40 times sweeter than sugar.
		This product has a bitter taste and is often used in combination with other sweeteners.
	www.norfoods.se /lundberg/html/eng_html/products/cyclamate.htm (47 words)

	Science Fair Projects - Cyclamate
		Cyclamate is an artificial sweetener that was discovered in 1937 at the University of Illinois by graduate student Michael Sveda.
		Cyclamate is 30–50 times sweeter than sugar (depending on concentration; it is not a linear relationship), making it the least potent of the commercially used artificial sweeteners.
		Cyclamate is the sodium or calcium salt of cyclamic acid (cyclohexanesulfamic acid).
	www.all-science-fair-projects.com /science_fair_projects_encyclopedia/Cyclamate (632 words)

	cyclamate - Encyclopedia.com
		The sodium and calcium salts were commonly used as artificial sweeteners until 1969, when their use was banned by the U.S. Food and Drug Administration after reports that ingestion of large quantities of cyclamates appeared to cause cancer in some animals.
		Sodium cyclamate is used as a sweetener for low-caloric and dietetic...
		Cyclamate is a controversial sweetener which was banned...
	www.encyclopedia.com /doc/1E1-cyclamat.html (950 words)

	ACSH > Facts & Fears > Archives
		Cyclamate had been used for nearly twenty years and had been deemed by the FDA to be GRAS (generally recognized as safe) and thus exempt from regulation under the Food, Drug, and Cosmetic Act.
		Cyclamate was introduced in the 1950s, primarily as a drug to help the obese lower caloric intake, but was soon reclassified as a food additive.
		Abbott Laboratories, submitting evidence that cyclamate was the most studied component of the human diet, asked the FDA in 1974 to reconsider its decision, but its appeal was denied.
	www.acsh.org /factsfears/newsID.458/news_detail.asp (688 words)

	It:Cyclamate - ChemWiki
		Cyclamate, also known as (E952) is an artificial sweetener that was discovered in 1937 at the University of Illinois.
		Cyclamate is the sodium or calcium salt of cyclamic acid(cyclohexanesulfamic acid).
		Cyclamate was in use until 1969 as an artificial sweetener, until their use was banned by the U.S. Food and Drug Administration after reports that large quantities of cyclamates could cause cancer in some animals.
	www.ch.ic.ac.uk /wiki/index.php?title=It:Cyclamate&redirect=no (621 words)

	126. Calcium cyclamate (FAO Nutrition Meetings Report Series 44a)
		In a test designed to study the influence of cyclamate on caloric utilization, groups of 6 male rats were fed 5 g/day basal diets supplemented with 0, 1 and 2 g/day of sucrose with and without 1, 2 and 4 per cent.
		Calcium cyclamate was fed to groups of rats at 0, 5 and 10 per cent.
		A study of cyclamate ingestion was carried out in 164 children, aged 3-16 years, in four weight classes of 15-45 lbs., 45-75 lbs., 75-105 lbs.
	www.inchem.org /documents/jecfa/jecmono/v44aje35.htm (1649 words)

	Kids.Net.Au - Encyclopedia > Cyclamate
		Cyclamate is a man-made chemical that people used instead of sugar.
		The Food and Drug Administration banned the sale of cyclamates in 1973 because lab tests showed that large amounts of cyclamates can cause bladder cancer in rats.
		Cyclamates are still used as sweeteners in many other parts of the world.
	www.kids.net.au /encyclopedia-wiki/cy/Cyclamate (76 words)

	Irish Statute Book, Statutory Instruments, S.I. No. 49/1970 — Health (Cyclamate in Food) Regulations, 1970.
		"cyclamate" means any one of the substances conforming to the descriptions, specifications and requirements for cyclamic acid, calcium cyclamate or sodium cyclamate contained in the Irish Pharmacopoeia 1968;
		(1) A person shall not advertise for sale cyclamate for use in a food for human consumption unless the advertisement includes a statement that the cyclamate should be used only in a food for consumption by persons on medical advice.
		The provisions of these Regulations shall not apply in the case of any cyclamate or any food which is intended to be exported or re-exported.
	www.irishstatutebook.ie /ZZSI49Y1970.html (729 words)

	Cyclamate - Drug information from Medic8.com
		Cyclamate was marketed in tablet form for use by diabetics as an alternative tabletop sweetener, as well as in a liquid form; one such product was named 'Sucaryl' and is still available in non-US and British markets.
		Cyclamate is 30-50 times sweeter than sugar (depending on concentration; it is not a linear relationship), making it the least potent of the commercially used artificial sweeteners.
		Cyclamate is approved as a sweetener in more than 55 countries: for example, the brand-name beverage sweetener Sweet'N Low, which contains only dextrose, saccharin, cream of tartar and calcium silicate in the United States, contains cyclamate in Canada (where saccharin is banned except for diabetic usage).
	www.medic8.com /medicines/Sodium-cyclamate.html (702 words)

	Cyclamates go on sale despite testicle atrophy evidence
		The artificial sweetener sodium cyclamate is now on sale in a range of soft drink products and in popular food supplements, despite research on rats and monkeys showing that low levels of the chemical can lead to atrophy of the testicles and reduced testosterone levels.
		The levels of cyclamate permitted in soft drinks -- 400mg per litre -- are so high that a single litre would take a typical adult over their daily acceptable limit, and government figures analysed by the Food Commission show that children under five could routinely exceed their acceptable levels by 140%.
		Sodium cyclamate is banned in the USA and was not permitted in UK foods until the beginning of 1996, when it was added to the list of permitted sweeteners under new sweetener regulations, supposedly to harmonise with Europe.
	www.foodcomm.org.uk /press_97_cyclams.htm (289 words)

	Cyclamate is an artificial sweetener that was discovered...
		Cyclamate is often used synergistically with other artificial sweeteners such as saccharin (such as 10 parts cyclamate to 1 part saccharin).
		Sodium and Calcium Cyclamate are about 30 to 50 times sweeter than sucrose (it depends on concentration since it is not a linear relationship), which is least of the commercially used artificial sweeteners.
		Cyclamate is the calcium or sodium salt of cyclamic acid (cyclohexanesulfamic acid) (calcium cyclohexylsulfamate and sodium cyclohexylsulfamate).
	www.geodatabase.de /Cyclamate (345 words)

	Sweeteners
		Cyclamate is said to work synergic with other sweeteners and may frequently result in a decrease of aftertaste.
		Cyclamate is not metabolized in most people, among the people where it is and to what extent it is metabolized, cyclohexylamine mainly constitutes the metabolite.
		Cyclamate has achieved a wide application as a consequence of its harmlessness, its stability in heat, among other things, and its good qualities in the context of combined sweetening.
	www.karelma.com /english/body/sugar.html (1757 words)

	Artificial Sweeteners and Cancer: Q and A - National Cancer Institute
		Questions about artificial sweeteners and cancer arose when early studies showed that cyclamate in combination with saccharin caused bladder cancer in laboratory animals.
		Because the findings in rats suggested that cyclamate might increase the risk of bladder cancer in humans, the FDA banned the use of cyclamate in 1969.
		Upon the reexamination of cyclamate carcinogenicity and the evaluation of additional data, scientists concluded that cyclamate was not a carcinogen or a co-carcinogen (a substance that enhances the effect of a cancer-causing substance).
	www.cancer.gov /cancertopics/factsheet/Risk/artificial-sweeteners (1096 words)

	Artificial Sweeteners Information
		Cyclamate was introduced into beverages and foods in the early 1950's, and it dominated the artificial sweetener market through most of the 1960s.
		In brief, Goyan's position was that the safety of cyclamate had not been demonstrated, that it had not been shown that cyclamate would not cause cancer and would not cause inheritable genetic damage.
		Particular emphasis was given by the FDA committee to the evaluation of date that seemed to implicate cyclamate as a cause of tumors in the urinary bladders of rats and in the lungs, liver and lymphoreticular tissues of mice.
	www.freediettips.com /diet_artificial_sweeteners.htm (2903 words)

	Low-Calorie Sweeteners: Adding Reduced-Calorie Delights to a Healthful Diet
		The FDA is currently considering petitions to approve other low-calorie sweeteners, including sucralose, alitame and cyclamate, all of which are already approved for use in numerous other countries.
		Cyclamate is approved for use in Canada and more than 50 countries in Europe, Asia, South America and Africa.
		Cyclamate is 30-times sweeter than sucrose and is heat-stable.
	www.ific.org /foodinsight/1998/jf/lcsfi198.cfm (1437 words)

	Rev. Bras. Saude Mater. Infant. vol.3 no.2; Resumen: S1519-38292003000200003 (Site not responding. Last check: )
		Cyclamate is used as an artificial non-caloric sweetener in a variety of foods and beverages, being 30 times as sweet as sugar without the bitter after-taste of saccharin.
		Cyclamate and cyclohexylamine, its principal metabolite, can cross the human placenta exposing the fetus.
		Studies on the effects of sodium cyclamate in the human species are necessary, because in addition to replacing saccharose - harmful in individuals with diabetes or patients in whom weight reduction and control are essential for health - it does not cause dental caries.
	www.scielo.br /scielo.php?script=sci_abstract&pid=S1519-38292003000200003&lng=es&nrm=iso&tlng=en (140 words)

	The Secret to Good Tasting Light Foods and Beverages (Site not responding. Last check: )
		During the 1960s, cyclamate joined saccharin as a viable commercial sweetener, and the two ingredients in tandem were popular in diet soft drinks, tabletop sweeteners and other products.
		The primary advantage of this sweetener blend was that saccharin boosted the sweetening power of the less potent cyclamate (the two sweeteners have a synergistic effect — that is, the sweetness of the combination is greater than the sum of the individual parts).
		Additional low-calorie sweeteners, including alitame and cyclamate, could be available in the US in the near future.
	www.24hourfitness.com /html/nutrition/articles_p/lt_food_bev (1946 words)

	Non-Nutritive and Artificial Sweeteners
		Cyclamate was synthesized in 1937 at the University of Illinois by a student who accidentally discovered its sweet taste.
		Cyclamate was initially marketed as tablets that were recommended for use as a tabletop sweetener for people with diabetes and others who had to restrict their intake of sugar.
		Although it is approved for use in many countries, cyclamate is banned in the United States due to concerns over potential carcinogenicity.
	www.vitaminshoppe.com /content/en/healthguide/hncontent_printable.jsp?pagetitle=Healthnotes&queryString=org%3DVSI%26intsource%3Dhc%26ContentID%3D1845001%26category%3DFood_Guide%26title%3DNon%252DNutritive%2520and%2520Artificial%2520Sweeteners%26type%3D (878 words)

	Sweeteners in food formulation face new rules (Site not responding. Last check: )
		In the UK, cyclamates have not been widely used by UK manufacturers due to the regulatory position prior to the adoption to the original sweeteners directive in 1995 - in other words, they were not permitted under UK legislation.
		The patent for cyclamate, an artificial sweetener discovered in 1937 at the University of Illinois in the US, was initially purchased by chemical giant DuPont but later sold to Abbott Laboratories who undertook the necessary studies and submitted a New Drug Application in 1950.
		Cyclamate, approved in over 55 countries, is often used synergistically with other artificial sweeteners such as saccharin - such as 10 parts cyclamate to 1 part saccharin.
	www.foodnavigator.com /news-by-product/news.asp?id=50817&pff=1 (828 words)

	Bilim.org \| Sadece Bilim
		Cyclamate 1937 yılında Illinois Üniversitesinde bir doktora öğrencisi tarafından bulunmuş yapay bir tatlandırıcıdır.
		Cyclamate laboratuvarda ateş düşürücü bir kimyasal sentezlemekle uğraşırken elinden düşürdüğü sigarasını tekrar ağzına götürünce cyclamate’ın tatlı olduğunu farkeden Michael Sveda tarafından bulunmuştur.
		Bu yüzden cyclamate halen Amerika’da kullanımı yasaklanmış bir yapay tatlandırıcıdır.Özellikle diyet ürünler kullanan arkadaşların bu konuda dikkatli olmalarını öneririm.
	www.bilim.org /?s=haber&haberid=271 (189 words)

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