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Topic: Long term potentiation


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In the News (Wed 1 Oct 14)

  
 Long-term potentiation - Wikipedia, the free encyclopedia
LTP was discovered in the mammalian hippocampus by Terje Lømo in 1966 and has remained a popular subject of neuroscientific research since.
PKA's activity is enhanced during LTP induction by elevated levels of cAMP as a result of calcium's activation of adenylyl cyclase-1.
The late phase of LTP is dependent upon gene expression and protein synthesis, regulated largely by CREB-1.
en.wikipedia.org /wiki/Long-term_potentiation   (4193 words)

  
 Long-Term Potentiation and Memory -- LYNCH 84 (1): 87 -- Physiological Reviews
Long-term potentiation (LTP) in perforant path-granule cell synapses in urethane-anesthetized rats was inhibited by the Trk inhibitor tyrphostin AG879 (A), the MEK inhibitor PD98059 (B), and the PI 3-kinase inhibitor wortmannin (C).
synapses, induction of LTP in all subfields of the hippocampus
receptors in LTP was in 1991 with the observation that the nonselective
physrev.physiology.org /cgi/content/full/84/1/87   (10239 words)

  
 Long-Term Potentiation: What's Learning Got To Do With It?
The use of the term LTP to describe all forms of enhanced synaptic efficacy might lead a casual observer to conclude that a common mechanism is shared by all.
This synaptic potentiation was observed in a pathway from the thalamus to the amygdala, one that is thought to be involved in fear conditioning (Rogan and LeDoux 1995).
Accordingly, LTP is suggested to nonspecifically increase the effective salience of discrete external stimuli and thereby is capable of facilitating the induction of memories at distant synapses.
www.bbsonline.org /documents/a/00/00/04/82/bbs00000482-00/bbs.shors.html   (19647 words)

  
 Long-Term Potentiation
The behavior of certain synapses in the "CA1" region of the hippocampus of the rat (or mouse) is consistent with their being essential for this form of long-term memory.
LTP has also been demonstrated in neurons of the cerebellum.
LTP involves structural changes as well as functional ones.
users.rcn.com /jkimball.ma.ultranet/BiologyPages/L/LTP.html   (960 words)

  
 Long-term memory - Wikipedia, the free encyclopedia
Biologically, short-term memory is a temporary potentiation of neural connections that can become long-term memory through the process of rehearsal and meaningful association.
The proposed mechanism by which short-term memories move into LTM storage is via long-term potentiation, which leads to a physical change in the structure of neurons.
According to the theory of Tarnow, long term memories are stored in dream format (reminiscent of the Penfield and Rasmussen’s findings that electrical excitations of cortex give rise to experiences similar to dreams).
en.wikipedia.org /wiki/Long_term_memory   (774 words)

  
 Long-Term Potentiation
Long-term potentiation has been found to occur in the mammalian hippocampus.
LTP is one of the first examples of mechanisms of neural implementation of a cognitive function.
This was an extremely important finding because it suggested that LTP could be the cellular basis of neural implementation for learning and memory.
penta.ufrgs.br /edu/telelab/3/long_ter.htm   (144 words)

  
 Inhibition of Ganglionic Long-Term Potentiation Decreases Blood Pressure in Spontaneously Hypertensive Rats -- Alkadhi et al. 226 (11): 1024 -- Experimental Biology and Medicine
Role for protein kinase C in long-term potentiation of nicotinic transmission in the superior cervical ganglion of the rat.
Bachoo M, Polosa C. Preganglionic axons from the third thoracic spinal segment fail to induce long-term potentiation in the superior cervical ganglion of the cat.
Nitric oxide mediates long-term potentiation in rat superior cervical ganglion.
www.ebmonline.org /cgi/content/full/226/11/1024   (3136 words)

  
 OUP: Long-term Potentiation: Bliss
19 K Harris, J Fiala & L Ostroff: Structural changes at dendritic spine synapses during long-term potentiation
LTP is thought to play a central role in learning and memory, though the exact nature of its role is less clear.
It begins with lively accounts, by the scientists most closely involved, of the discovery of LTP and of the experiments that established its basic properties and induction mechanisms.
www.oup.co.uk /isbn/0-19-853030-7   (910 words)

  
 Long-Term Potentiation of Exocytosis and Cell Membrane Repair in Fibroblasts -- Togo et al. 14 (1): 93 -- Molecular Biology of the Cell
These requirements for long-term potentiation are not the result of nonspecific, deleterious effects of emetine treatment
Eliminating the CREB pathway only blocks long-term potentiation,
FM1-43 was loaded as in A. Short-term potentiation of membrane resealing in emetine-treated cells.
www.molbiolcell.org /cgi/content/full/14/1/93   (7205 words)

  
 Presynaptic release probability influences the locus of long-term potentiation
Here we report the use of a combination of quantal analysis procedures to provide evidence that both pre- and postsynaptic changes can contribute substantially to the maintenance of long-term potentiation in the CA1 region of the hippocampus.
Presynaptic release probability influences the locus of long-term potentiation
The initial setting of the presynaptic release mechanism seems to determine their relative importance.
dx.doi.org /10.1038/360070a0   (319 words)

  
 Fimbria-Fornix Lesions Compromise the Induction of Long-Term Potentiation at the Schaffer Collateral-CA1 Synapse in the Rat In Vivo -- Li et al. 93 (5): 3001 -- Journal of Neurophysiology
Fimbria-Fornix Lesions Compromise the Induction of Long-Term Potentiation at the Schaffer Collateral-CA1 Synapse in the Rat In Vivo -- Li et al.
Articles by Li, C. Articles by Christian, E. Fimbria-Fornix Lesions Compromise the Induction of Long-Term Potentiation at the Schaffer Collateral-CA1 Synapse in the Rat In Vivo
length until a sufficient length was reached to induce LTP of
dx.doi.org /10.1152/jn.00546.2004   (297 words)

  
 Episodic Memory Hippocampus Long-term potentiation Recruitment
SMRITI* is a computational model that demonstrates how a cortically expressed transient pattern of rhythmic activity representing an event or a situation can be rapidly transformed into a persistent and robust memory trace as a result of long-term potentiation and long-term depression within structures whose architecture and circuitry are consistent with those of the HS.
Our ability to remember events in our daily life and acquire specific facts after reading a newspaper or watching a newscast underscores our ability to rapidly acquire new memories.
But how the HS subserves this mnemonic function is not fully understood.
www.icsi.berkeley.edu /~shastri/smriti   (219 words)

  
 CaMK Model for Long Term Potentiation
This java applet demonstrates the CaM Kinase II model for Long Term Potentiation
Lisman, J. and Zhabotinsky, A. A Model of Synaptic Memory: A CaMKII/PP1 Switch that Potentiates Transmission by Organizing an AMPA Receptor Anchoring Assembly.
This simulation was developed in John Lisman's laboratory and was programmed in accordance with the equations and descriptions given in the following two papers:
www.cs.brandeis.edu /~dna/ns/final/camk.html   (525 words)

  
 A hebbian form of long-term potentiation dependent on mGluR1a in hippocampal inhibitory interneurons -- Perez et al., 10.1073/pnas.161493498 -- Proceedings of the National Academy of Sciences
GABAB receptor- and metabotropic glutamate receptor-dependent cooperative long-term potentiation of rat hippocampal GABAA synaptic transmission
LTP was expressed as a decrease in failure rates and an increase
LTP was induced specifically in interneurons in stratum oriens
www.pnas.org /cgi/content/abstract/161493498v1   (586 words)

  
 Long-term potentiation
Press Go button to find more articles on long-term potentiation.
Expert peer-review journal published by the editorial group
neurobiologyoflipids.org /ltp.html   (42 words)

  
 Cognitive Science Artificial Intelligence Computational and Cognitive Neuroscience Temporal Synchrony Neural Networks Binding Hippocampus Episodic Memory Long-term potentiation Language Understanding Lokendra Shastri
Cognitive Science Artificial Intelligence Computational and Cognitive Neuroscience Temporal Synchrony Neural Networks Binding Hippocampus Episodic Memory Long-term potentiation Language Understanding Lokendra Shastri
Computational and Cognitive Neuroscience, Artificial Intelligence, and Cognitive Science: neurally motivated models of learning, memory, knowledge representation, inference, and decision making; representation of causal and semantic knowledge; episodic memory formation via cortico-hippocampal interactions; role of temporal synchrony in neural information processing; spatio-temporal pattern recognition; semantic networks.
www.icsi.berkeley.edu /~shastri   (155 words)

  
 Protein kinase M xi examined, role in long-term depression defined : Epilepsy.com
Sajikumar and colleagues published their study in the Journal of Neuroscience (Synaptic tagging and cross-tagging: The role of protein kinase M xi in maintaining long-term potentiation but not long-term depression.
Protein kinase M xi examined, role in long-term depression defined : Epilepsy.com
Protein kinase M xi examined, role in long-term depression defined
www.epilepsy.com /newsfeed/pr_1123594227.html   (413 words)

  
 Long-term memory - Wikipedia, the free encyclopedia
Biologically, short-term memory is a temporary potentiation of neural connections that can become long-term memory through the process of rehearsal and meaningful association.
As long-term memory is subject to fading in the natural forgetting process, several recalls/retrievals of memory may be needed for long-term memories to last for years, dependent also on the depth of processing.
According to the theory of Tarnow, long term memories are stored in dream format (reminiscent of the Penfield and Rasmussen’s findings that electrical excitations of cortex give rise to experiences similar to dreams).
en.wikipedia.org /wiki/Long_term_memory   (445 words)

  
 Mechanisms of Synaptic Plasticity
While there are many forms of short term plasticity, such as paired pulse facilitation/depression, these pages are intended to detail some of the work of Centre PIs in the area of long-term plasticity, namely long-term potentiation and long-term depression.
DHPG-induced LTD: This form of LTD was first identified here at the MRC Centre with the use of the Group I mGlu receptor agonists DHPG, and later shown to be dependent on the mGlu5 receptor by using CHPG.
Paired-pulse induced LTD: This form of LTD is induced by a train of pairs of stimulation and has been shown to be independent of NMDA receptors but dependent on mGlu receptors.
www.bris.ac.uk /Depts/Synaptic/research/projects/mechanisms/mechanisms.htm   (1251 words)

  
 Long-term potentiation - Wikipedia, the free encyclopedia
Most neuroscientific learning theories regard long-term potentiation and its opposing process, long-term depression, as the cellular basis of learning and memory.
LTP was discovered in the mammalian hippocampus by Terje Lømo in 1966 and has remained a popular subject of neuroscientific research since.
Collingridge GL, Kehl SJ, McLennan H. "Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus." J Physiol.
en.wikipedia.org /wiki/Long-term_potentiation   (4251 words)

  
 Conditions for the Induction of Long-Term Potentiation and Long-Term Depression by Conjunctive Pairing in the Dentate Gyrus In Vitro -- Wang et al. 78 (5): 2569 -- Journal of Neurophysiology
, T. Long-term depression in rat visual cortex is associated with a lower rise of postsynaptic calcium than long-term potentiation.
Conditions for the Induction of Long-Term Potentiation and Long-Term Depression by Conjunctive Pairing in the Dentate Gyrus In Vitro -- Wang et al.
, J. Rapid dendritic Ca influx is associated with induction of homosynaptic long-term depression in adult rat hippocampus.
jn.physiology.org /cgi/content/full/78/5/2569   (3468 words)

  
 Olfactory Learning Modifies Predisposition for Long-term Potentiation and Long-term Depression Induction in the Rat Piriform (Olfactory) Cortex -- Lebel et al. 11 (6): 485 -- Cerebral Cortex
Bliss TV, Collingridge GL (1993) A synaptic model of memory: long term potentiation in the hippocampus.
Olfactory Learning Modifies Predisposition for Long-term Potentiation and Long-term Depression Induction in the Rat Piriform (Olfactory) Cortex
Olfactory Learning Modifies Predisposition for Long-term Potentiation and Long-term Depression Induction in the Rat Piriform (Olfactory) Cortex -- Lebel et al.
cercor.oxfordjournals.org /cgi/content/full/11/6/485   (2972 words)

  
 _12.html
One role they have is in synaptic plasticity: long-term potentiation and long-term depression, in particular.
For long term depression, nitric oxide is an anterograde factor that aids in the downregulation of the AMPA receptors in the postsynaptic Purkinje neurons.
The role and mechanism of carbon monoxide is not known in long-term depression.
sulcus.berkeley.edu /mcb/165_001/papers/manuscripts/_12.html   (3246 words)

  
 Long-Term Potentiation
This is called long-term depression or LTD. It involves Glu binding to a different type of NMDA receptor.
Slow, weak stimulation of CA1 neurons also brings about long-term changes in the synapses, in this case, a reduction in the sensitivity.
Humans undergoing electroshock treatment (to alleviate their depression) are unable to remember events that occurred just prior to the treatment, but their memory of earlier events is unimpaired.
users.rcn.com /jkimball.ma.ultranet/BiologyPages/L/LTP.html   (960 words)

  
 Long-term potentiation -- Facts, Info, and Encyclopedia article
"The concept of long term potentiation of transmission at synapses." Prog Neurobiol.
Timothy Bliss, who joined the Andersen laboratory in 1968, collaborated with Lømo in 1973 to publish the first characterization of LTP in (Any of various burrowing animals of the family Leporidae having long ears and short tails; some domesticated and raised for pets or food) rabbit hippocampus.
When an axon of cell A is near enough to excite a cell B and repeatedly or persistently takes part in firing it, some growth process or metabolic change takes place in one or both cells such that A's efficiency, as one of the cells firing B, is increased.
www.absoluteastronomy.com /encyclopedia/l/lo/long-term_potentiation.htm   (3310 words)

  
 Single protein appears central to the formation of the long-term memories
A comparatively small burst of electric current simulates a phenomenon thought to parallel short term memory, and is referred to as early long-term potentiation, or E-LTP.
When a long term memory is made, researchers believe that neurons gain the capacity to transmit a much stronger electrical impulse than they otherwise would, and require much less neurotransmitter.
Long term memory refers to the ability to remember things for more than a day--sometimes for many years.
www.news-medical.net /?id=5607   (1287 words)

  
 HHMI News: Researchers Find Enzyme Crucial to Preservation of Memories
The scientists began their studies to clarify the enzyme’s role in late long-term potentiation (L-LTP), the process by which enduring memories are established through a mechanism of activating genes that trigger protein synthesis.
According to the researchers, their experiments — which showed that defects in a key biochemical signaling pathway were responsible for the animals’ inability to improve their long-term memory in a series of maze tests — constitute a powerful approach to understanding molecules involved in learning and memory.
“CaMKIV had been implicated in long-term memory pathways in the past, but previous studies had involved global knockout of the enzyme in the entire animal,” said Tonegawa.
www.hhmi.org /news/tonegawa.html   (1003 words)

  
 Increasing age reduces expression of long-term depression and dynamic range of transmission plasticity in CA1 field of the rat hippocampus.
We found significant long-term depression in slices of all groups stimulated with protocol 1; however, the magnitude of long-term depression in slices from 24- and 36-week-old rats was significantly lower than that in slices from two- and 12-week old rats, although there was no such difference in the magnitude of long-term potentiation between slices.
Long-term depression, depotentiation and long-term potentiation of field excitatory postsynaptic potentials in the CA1 field of the hippocampus were studied in slices from two-, 12-, 24- and 36-week-old rats.
The decrease in the dynamic range in slices from 36-week-old rats was due to a diminished capacity to depotentiate the nearly saturated long-term potentiation and not due to a decreased long-term potentiation expression in these slices.
www.arclab.org /medlineupdates/abstract_9483555.html   (362 words)

  
 Publications and Reprint Requests
Atkins, C.M., Chen, S.-J., Klann, E., and Sweatt, J.D. Increased phosphorylation of myelin basic protein during hippocampal long-term potentiation.
Chen, S.-J., Sweatt, J.D., and Klann, E. (1997) Enhanced phosphorylation of the postsynaptic PKC substrate RC3/neurogranin in hippocampal long-term potentiation.
Atkins, C.M., Chen, S.-J., Klann, E., and Sweatt, J.D. (1997) Increased phosphorylation of myelin basic protein during hippocampal long-term potentiation.
www.pitt.edu /~neurosci/faculty/klannpublications.htm   (362 words)

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