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Topic: Phenylethylamine

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Science

	[No title]
		Earlier experiments had shown that urinary elimination of phenylethylamine (PEA), a metabolite of phenylalanine, is decreased in some cases of depression and therefore, Yaryura-Tobias believed that the administration of the phenylethylamine precursor, phenylalanine might improve cases of depression.
		The authors hypothesize that a reduction in brain levels of phenylethylamine (the phenyalalnine metabolite) was one factor in causing the depression.
		At the start of the study, the depressed patients had significantly lower blood and urine concentrations of phenylacetic acid (PAA), a metabolite of phenylethylamine (which is a metabolite of phenylalanine) as compared to the 48 control subjects.
	www.holisticmed.com /aspartame2/aspart.p11b (5633 words)

	Lipodrene-SR (Site not responding. Last check: 2007-10-14)
		Phenylethylamine has always been the darling of the pharmacologist in that it is structurally clean — it is naturally present in human fluids and tissues - and because it has a close chemical relationship to pharmaceutical stimulants.
		Phenylethylamine is also found in chocolate, and is responsible for its effects on mood, appetite and sense of well being.
		Phenylethylamine is intrinsically likely the cleanest stimulant known to man. Its ability to stimulate the central nervous system without causing jitters or nervousness is extraordinary!
	www.naturalhealthconsult.com /Monographs/Lipodrene-SR.html (1015 words)

	Amphetamine-like chemical linked to exercise mood boosts - 27 September 2001 - New Scientist (Site not responding. Last check: 2007-10-14)
		Their study of 20 young men suggests that phenylethylamine, which has a chemical structure very similar to amphetamine, may play a key role in the "runner's high".
		Phenylethylamine was an obvious chemical to investigate, she says.
		Billet's team found that levels of a metabolite of phenylethylamine - an indicator of levels of phenylethylamine in the brain - rocketed after exercise.
	www.newscientist.com /article.ns?id=dn1352 (450 words)

	Phenylethylamine (Site not responding. Last check: 2007-10-14)
		It is believed to work by making the brain release b-endorphin, an opioid peptide which is the driving force behind the pleasurable effects.
		Phenylethylamine is known as the "love drug" and is thought be be the reason why chocolate is said to be an aphrodisiac.
		It is a chemical that mimics the brain chemistry of a person in love, so when levels of phenylethylamine are high in the body it relieves depression from unrequited love.
	www.chm.bris.ac.uk /webprojects2001/millward/phenylethylamine.htm (128 words)

	News - Exercise Levels Of Phenylethylamine May Damp Depression (Site not responding. Last check: 2007-10-14)
		Phenylethylamine is an endogenous neuro-amine that has been linked to the regulation of physical energy, mood, and attention.
		There is evidence that phenylethylamine and phenylacetic acid levels are very low in the biological fluids of depressed patients.
		Administration of phenylethylamine or its precursor L-phenylalanine, in conjunction with selegiline, a selective monoamine oxidase B inhibitor, has been reported to alleviate depression and to produce improvements in mood.
	docguide.com /news/content.nsf/news/8525697700573E1885256AD40022E97C (578 words)

	Work out that depression
		The team tested urine samples on their "day of rest", analyzing for phenylacetic acid, a by-product of turnover of the endogenous neurotransmitter phenylethylamine, involved in the brain's activity during exercise.
		Previous research has simply measured levels of phenylethylamine itself but the researchers believe their approach provides a more accurate assessment of the compound's activity in the body.
		However, they point to the structural similarity of phenylethylamine to the amphetamine drugs as a possible cue to the "high" felt by runners, a phenomenon linked to natural endorphin activity in the brain.
	www.reactivereports.com /21/21_1.html (484 words)

	Navarre Press - Weekly News & Information (Site not responding. Last check: 2007-10-14)
		The investigators found that a bout of aerobic activity appears to elevate the body's levels of phenylethylamine, a natural chemical linked to energy, mood and attention.
		For 18 of the 20 men, urine phenylacetic acid--which reflects phenylethylamine levels--was higher after exercise, increasing anywhere from 14% to 572%.
		Billett and colleagues suggest that the effects of exercise on phenylethylamine levels be tested in people with clinical depression.
	www.navarrepress.com /archive/101201/sports/s5.html (239 words)

	Phenylethylamine : the endogenous amphetamine ? (Site not responding. Last check: 2007-10-14)
		Phenylethylamine, however, is not stored in intra-neuronal vesicles and is rapidly degraded by monoamine oxidase-B. Despite its short half-life, phenylethylamine attracts attention as an endogenous amphetamine since it can potentiate catecholaminergic neurotransmission and induce striatal hyperreactivity.
		Excess phenylethylamine has been invoked particularly in paranoid schizophrenia, in which it is thought to act as an endogenous amphetamine and, therefore, would be antagonized by neuroleptics.
		The importance of phenylethylamine in mental disorders is far from fully elucidated but the evolution of phenylethylamine concentrations in relation to symptoms remains a worthwhile investigation for individual psychotic patients.
	www.chocolate.org.uk /pea.html (189 words)

	International Antiaging Magazine - Increasing Optical Healthsapn with Deprenyl
		Phenylethylamine is a trace amine made in the brain that modulates (enhances) the activity of dopamine and noradrenaline neurons.
		Phenylethylamine is the preferred substrate for MAO-B, the MAO that deprenyl inhibits.
		Vitamin B6 activates the enzyme that converts phenylalanine to phenylethylamine, so the combination of low-dose deprenyl, B6, and phenylalanine is another biological way to enhance both phenylethylamine and catecholamine brain function, and thus diminish depression.
	www.antiaging-magazine.com /articles/article_4_1.html (3272 words)

	Phenylethylamine, a possible link to the antidepressant effects of exercise? -- Szabo et al. 35 (5): 342 -- British ...
		Phenylethylamine is an endogenous neuroamine that has been linked
		than phenylethylamine for examining the modulatory role of phenylethylamine.
		In its role as an inhibitor of noradrenergic reuptake, phenylethylamine
	bjsm.bmjjournals.com /cgi/content/full/35/5/342 (1151 words)

	Bulk Nutrition - D,L-Phenylalanine by Andrew Novick (Site not responding. Last check: 2007-10-14)
		DLPA plays an important role in providing the building blocks for dopamine and phenylethylamine (the body’s natural amphetamine) and has the ability to greatly increase the action of our endorphins (the body’s natural morphine).
		Phenylethylamine modulation of affect: therapeutic and diagnostic implications.
		Effect of dietary phenylalanine on the plasma concentrations of phenylalanine, phenylethylamine and phenylacetic acid in healthy volunteers.
	www.bulknutrition.com /?articleID=62 (875 words)

	Decreased beta -phenylethylamine in CSF in Parkinson's disease -- Zhou et al. 63 (6): 754 -- Journal of Neurology, ...
		In vivo release of endogenous dopamine from rat caudate nucleus by phenylethylamine.
		N, N-Dipropargyl-2- phenylethylamine, a potent prodrug of 2-phenylethylamine: neurochemical and neuropharmacological studies in rat.
		Knoll J, Miklya I, Knoll B, Marko R, Racz D. Phenylethylamine and tyramine are mixed-acting sympathomimetic amines in the brain.
	jnnp.bmjjournals.com /cgi/content/full/63/6/754 (2338 words)

	Phenylalanine (Site not responding. Last check: 2007-10-14)
		LPA can also be converted (through a separate pathway) to phenylethylamine, a substance that occurs naturally in the brain and appears to elevate mood.
		As a result, DPA is converted primarily to phenylethylamine (the potential mood elevator).
		Clinical studies on the phenylethylamine hypothesis of affective disorder: urine and blood phenylacetic acid and phenylalanine dietary supplements.
	www.kingsoopers.com /hn/Supp/Phenylalanine.htm (779 words)

	'Runner's High' May Be Reaction To Phenylethylamine
		Now it appears that the antidepressant effects may be due to a chemical called phenylethylamine.
		The study required that they stop exercise completely for a day, during which their urine samples were measured for phenylacetic acid, a by-product of phenylethylamine turnover, and a more accurate measure of the chemical.
		There may be many factors involved in the phenylacetic acid response to exercise, say the authors, but considering that its chemical structure is very similar to that of amphetamines, it may be that this chemical is part of a “runner’s high,” a phenomenon linked to natural endorphin activity in the brain.
	unisci.com /stories/20013/0928016.htm (314 words)

	Phenylethylamine and Chocolate, Natural Stimulant from Chocolate
		Chocolate also contains phenylethylamine, a neurotransmitter that makes us feel more alert and gives us a sense of well being and contentment.
		Phenylethylamine works by stimulating the brain's pleasure centres and reaches peak levels during orgasm.
		Researchers found that a session of moderate aerobic activity appears to elevate the body's levels of phenylethylamine, a natural chemical linked to energy, mood and attention.
	www.chocolatehotchocolate.com /phenylethylamine-chocolate.htm (116 words)

	NU business students look to defend Beanpot title (Site not responding. Last check: 2007-10-14)
		Phenylethylamine is a natural chemical that makes us feel good – as good as a handful of MandM’s, in fact.
		Researchers believe that our body releases phenylethylamine when we are in love, thus producing the elevation of mood.
		It’s the amphetamine-like nature of phenylethylamine that is responsible for mood swings.
	www.northeastern.edu /newpr/2-04/chocolate.shtml (395 words)

	Epic Attitude shown remarkable results in mood improvement (Site not responding. Last check: 2007-10-14)
		Phenylethylamine is what causes "Runner High" - the mild euphoric effect experienced by long distance runners.
		Phenylethylamine in the ingredient in chocolate believed to cause its mood enhancing effect, and thus our craving for chocolate!
		Yet the positive effect of this naturally occurring substance on mood is astonishing and the research is compelling.
	epiccoffee.com /attitude.shtml (199 words)

	22-1/O. Beck.../Presence of Phenylethylamine in Hallucinogenic Psilocybe Mushroom... (Site not responding. Last check: 2007-10-14)
		The use of mushrooms containing the hallucinogenic substance psilocybin for intentional intoxication is relatively common.
		This study demonstrates the presence of phenylethylamine in the species Psilocybe semilanceata using gas chromatography–mass spectrometry and shows that the amount of this substance may vary much more than that of psilocybin.
		Comparison of the symptoms observed in clinical cases of magic mushroom intoxication with those after intake of pure psilocybin or phenylethylamine suggests that phenylethylamine might have a role in the development of adverse reactions to Psilocybe mushroom intake.
	www.jatox.com /abstracts/1998/jan-feb/becjiab.htm (187 words)

	phenylethylamine
		I suspect that this chemical is related to endorphins, driven by the parasympathetic nervous system and therefore is directly dependant upon the way we breathe.
		There is probably also a need for adequate foods containing phenylethylamine (not to be confused with phenylalinine) so that we get it synergized and balanced with other natural live substances.
		Over a period of time amines, which includes phenylethylamine, can build up in your system causing reactions that mimic allergies.
	www.breathing.com /articles/phenylethylamine.htm (547 words)

	Localization of Periplasmic Redox Proteins of Alcaligenes faecalis by a Modified General Method for Fractionating ...
		Aromatic amine dehydrogenase (AADH) from Alcaligenes faecalis is induced during growth on phenylethylamine (19).
		AADH and azurin are associated in the periplasm prior to release
		To identify which of these proteins are specifically induced by phenylethylamine, cells were also grown on Luria-Bertani (LB)
	jb.asm.org /cgi/content/full/181/20/6540 (1329 words)

	Nutranews : information et actualité santé : nutrition, prévention du vieillissement... (Site not responding. Last check: 2007-10-14)
		Phenylethylamine modulation of affect : therapeutic and diagnostic implications ?
		Does phenylethylamine act as an endogenous amphetamin in some patients ?
		Phenylethylamine, a possible link to the andepressant effects of exercise.
	www.nutranews.org /fra/index.php?articleid=4565 (1543 words)

	[No title]
		It happens that a romantic reaction to another human being sets off a chemical reaction in the body.
		It is no accident that we talk about sexual chemistry because the substances produced in the body (WHERE?) are closely related to the amphetamine drugs.
		It is no accident that we talk about sexual chemistry because the substances produced in the body are closely related to the amphetamine drugs.
	www.chm.bris.ac.uk /motm/pending/PEA.doc (1425 words)

	ADHD and beta-Phenylethylamine -- Neurotransmitter.net (Site not responding. Last check: 2007-10-14)
		Findings were compared with those obtained in age-matched controls and diseased controls including patients with attention deficit-hyperactivity disorder (ADHD), infantile autism, and mental retardation.
		"Children with attention deficit disorder with hyperactivity were given either methylphenidate hydrochloride or dextroamphetamine sulfate to compare the effects on urinary excretion of catecholamines, indoleamines, and phenylethylamine (PEA).
		Kusaga A, Yamashita Y, Koeda T, Hiratani M, Kaneko M, Yamada S, Matsuishi T. Increased urine phenylethylamine after methylphenidate treatment in children with ADHD.
	www.neurotransmitter.net /adhdpea.html (1794 words)

	Chiral recognition and the determination of optical purity of a-phenylethylamine using ...
		The liquid secondary ion (LSI) mass spectra of a mixture of
		- phenylethylamine in the presence of benzylamine as reference compound and glycerol as matrix showed [(mannose + (R)- / (S)-
		The significant difference was observed in the relative peak intensity (RPI) values calculated from the ion abundances of ion a and b.
	www.impub.co.uk /abs/EMS05_0485.html (189 words)

	green superfoods, Phenylethylamine, klamath blue green algae, crystal manna
		You can finally purchase all of your favorite wild blue green algae products online.
		Our organic green superfoods are high in phenylethylamine and phycocyanin, (which is the leading natural anti-inflammatory supplement).
		If you're looking for the best blue green algae from Klamath Lake, as a direct supplement or as an ingredient in our food enzymes and organic pet food, this is the place.
	www.ancientsunnutrition.com (90 words)

	MAPS: endogenous phenylethylamine (Site not responding. Last check: 2007-10-14)
		Hi all, Seems that the forum has been a little quiet lately...so how about some more talk about the body's own phenylethylamine produced in the pituitary, and it's relation to the feeling of falling in love.
		Does anyone know of any other studies or new research that points to this area?
		How about advances in joining a synthetic form of endogenous phenylethylamine to a carrier molecule in order to enable it to traverse the blood brain barrier?
	www.maps.org /pipermail/maps_forum/1998-January/000589.html (130 words)

	Erowid Mushroom Vault : Journal Article #11
		Become a member and get your choice of drug related books!
		This study demonstrates the presence of phenylethylamine in the species Psilocybe semilanceata using gas chromatography-mass spectrometry and shows that the amount of this substance may vary much more than that of psilocybin.
		The highest amount of phenylethylamine (146 microg/g wet weight) was observed in mushrooms from a case of three young men hospitalized because of adverse reactions.
	www.erowid.org /plants/mushrooms/mushrooms_journal11.shtml (193 words)

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