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Topic: Sickle cell anemia

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Red blood cell

Sickle cell anaemia

Fetal hemoglobin

Anemia

Polygenic

Reticulocyte

Anaemia

Thalassemia

Basophil granulocyte

Price equation

Genetic disorder

Dominant gene

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Recessive gene

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	What Is Sickle Cell Anemia?
		Sickle cell anemia is a serious disease in which the body makes abnormally shaped red blood cells.
		Sickle cell anemia is an inherited (genetic) disorder.
		Anemia is the term for having a shortage of red blood cells in your blood.
	www.nhlbi.nih.gov /health/dci/Diseases/Sca/SCA_WhatIs.html (415 words)

	Sickle Cell Anemia
		Sickle cell disease is an inherited blood disorder characterized by defective hemoglobin.
		Sickle cell hemoglobin molecules are stiff and form into the shape of a sickle or a scythe.
		Sickle cell disease is an inherited disease caused by a genetic mutation.
	www.umm.edu /blood/sickle.htm (1687 words)

	Sickle Cell Anemia
		Sickle cell anemia is an inherited blood disorder, characterized primarily by chronic anemia and periodic episodes of pain.
		Studies show that in areas where malaria was a problem, children who inherited one sickle hemoglobin gene--and who, therefore, carried the sickle cell trait--had a survival advantage: unlike the children who had normal hemoglobin genes, they survived the malaria epidemics; they grew up, had their own children, and passed on the gene for sickle hemoglobin.
		Sickle cell anemia patients with severe chest or back pain that prevents them from breathing deeply may be able to avoid potentially serious lung complications associated with acute chest syndrome by using an incentive spirometer.
	www.fbhc.org /Patients/Modules/sicklecell.cfm (2696 words)

	Sickle cell disease - Genetics Home Reference
		Sickle cell disease is a group of disorders that affects hemoglobin, the molecule in red blood cells that delivers oxygen to cells throughout the body.
		Mutations in the HBB gene cause sickle cell disease.
		In people with sickle cell disease, at least one of the beta hemoglobin subunits in hemoglobin is replaced with hemoglobin S. In sickle cell anemia, which is a common form of sickle cell disease, hemoglobin S replaces both beta hemoglobin subunits in hemoglobin.
	ghr.nlm.nih.gov /condition=sicklecellanemia (947 words)

	TUTORIAL: Sickle-cell Anemia
		Sickle cell anemia is a disease in which the patient's red blood cells have an abnormal shape much like that of a sickle.
		The sickle cell anemia mutation is in the beta chain of hemoglobin.
		So people who had two sickle cell hemoglobin genes died of sickle cell anemia, and people who two normal genes died of malaria, but those with one of each gene lived to pass on the sickle cell hemoglobin gene to their children.
	www.bioquest.org /bioinformatics/module/tutorials/Sickle_Cell_Anemia (3266 words)

	Sickle Cell Anemia
		sickle cell disease sickle cell disease or sickle cell anemia,inherited disorder of the blood in which the oxygen-carrying hemoglobin pigment in erythrocytes (red blood cells) is abnormal.
		Sickle Cell Disease: When an individual has only hemoglobin S and no hemoglobin A, then he or she has sickle cell disease.
		If you and your partner both have sickle cell trait there is a 25% chance of the child having normal hemoglobin, a 50% chance of the child having the sickle cell trait, and a 25% of having sickle cell disease.
	www.uni.edu /darrow/frames/bio/sickle.html (2061 words)

	Sickle Cell Anemia
		Sickle cell anemia is an inherited blood disorder that causes red blood cells to be abnormally shaped.
		Sickle cell anemia is cause by a genetic change in hemoglobin, the oxygen-carrying protein inside the red blood cells.
		Symptoms of sickle cell anemia include paleness of skin as the anemia worsens, especially on the insides of eyelids, under fingernails and in the creases of the palm of the hand.
	www.hmc.psu.edu /healthinfo/s/sicklecell.htm (547 words)

	What is Sickle Cell Disease
		Sickle cell disease is an inherited blood disorder that affects red blood cells.
		Sickle Cell trait (AS) is an inherited condition in which both hemoglobin A and S are produced in the red blood cells, always more A than S. Sickle cell trait is not a type of sickle cell disease.
		Sickle cells are destroyed rapidly in the body of people with the disease causing anemia, jaundice and the formation of gallstones.
	www.sicklecelldisease.org /about_scd/index.phtml (924 words)

	Sickle-cell disease - Wikipedia, the free encyclopedia
		Sickle-cell anemia is caused by a missense mutation in the β-globin chain of hemoglobin, replacing the amino acid glutamic acid with the less polar amino acid valine at the sixth position of the β chain.
		The allele responsible for sickle cell anemia is autosomal recessive.
		Sickle cell anemia is caused by a recessive allele.
	en.wikipedia.org /wiki/Sickle_cell_anemia (2904 words)

	Sickle Cell Disease
		Sickle cell disease is an inherited disorder of the red blood cells characterized by abnormally shaped red cells.
		Symptoms of sickle cell disease vary and range from mild to severe, and symptoms may be less severe or different in children who have inherited a sickle cell gene from one parent and a different abnormal hemoglobin gene from the other.
		Infection used to cause many deaths in infants with sickle cell disease, but thanks to penicillin and appropriate immunizations, children with sickle cell disease are much more likely to live longer, healthier lives.
	kidshealth.org /parent/medical/heart/sickle_cell_anemia.html (1510 words)

	How Does Sickle Cell Cause Disease?
		Sickle cell disease is a blood condition seen most commonly in people of African ancestry and in the tribal peoples of India.
		Therefore, the inheritance of sickle cell disease depends totally on the genes of the parents.
		Sickle cell disease is determined at conception, when a person acquires his/her genes from the parents.
	sickle.bwh.harvard.edu /scd_background.html (1588 words)

	AllRefer Health - Sickle Cell Anemia (Anemia - Sickle Cell, Hemoglobin SS Disease (Hb SS), Sickle Cell Disease)
		Sickle cell anemia is an inherited disease in which the red blood cells, normally disc-shaped, become crescent shaped.
		Sickle cell anemia is caused by an abnormal type of hemoglobin (oxygen carrying molecule) called hemoglobin S. It is inherited as an autosomal recessive trait -- that is, it occurs in someone who has inherited hemoglobin S from both parents.
		Sickle cell anemia may become life-threatening when damaged red blood cells break down (hemolytic crisis), when the spleen enlarges and traps the blood cells (splenic sequestration crisis), or when a certain type of infection causes the bone marrow to stop producing red blood cells (aplastic crisis).
	health.allrefer.com /health/sickle-cell-anemia-info.html (712 words)

	TUTORIAL: Sickle-cell Anemia
		Sickle cell anemia is a disease in which the patient's red blood cells have an abnormal shape much like that of a sickle.
		The sickle cell anemia mutation is in the beta chain of hemoglobin.
		So people who had two sickle cell hemoglobin genes died of sickle cell anemia, and people who two normal genes died of malaria, but those with one of each gene lived to pass on the sickle cell hemoglobin gene to their children.
	bioquest.org /bioinformatics/module/tutorials/Sickle_Cell_Anemia/index.html (3266 words)

	Sickle Cell Anemia
		Sickle cell anemia occurs when a person inherits two abnormal genes (one from each parent) that cause their red blood cells to change shape.
		Sickle cell anemia is a blood disorder that affects hemoglobin (pronounced: hee-muh-glow-bin), a protein found in red blood cells that helps carry oxygen throughout the body.
		Sickle cell anemia is not contagious, so you can't catch it from someone else or pass it to another person like a cold or other infection.
	www.kidshealth.org /teen/diseases_conditions/blood/sickle_cell_anemia.html (618 words)

	Sickle Cell Anemia: treatment, symptoms, cause, prevention, complications, statistics, long-term outlook
		Sickle Cell is an inherited, chronic blood disease where the red blood cells become crescent shaped and function abnormally.
		Sickle Cell produces a chronic anemia which may become life-threatening when hemolytic crises (the breakdown of red blood cells) or aplastic crises (bone marrow fails to produce blood cells) occur.
		The symptoms include: family history of sickle cell anemia, fatigue, breathlessness, rapid heart rate, delayed growth and puberty, susceptibility to infections ulcers on the lower legs (in adolescents and adults) jaundice, attacks of abdominal pain, weakness, joint pain, fever, vomiting, bloody (hematuria) urination, excessive thirst, excessive penis pain, priapism, chest pain and decreased fertility.
	www.mamashealth.com /Sickle_Cell.asp (539 words)

	Sickle cell and African-Americans
		Sickle cell disease is a generic term for a group of genetic disorders characterized by the predominance of hemoglobin S (Hb S).
		These disorders include sickle cell anemia, the sickle beta thalassemia syndromes, and hemoglobinopathies in which Hb S is in association with another abnormal hemoglobin that not only can participate in the formation of hemoglobin polymers but also is present in sufficient concentration to enable the red cells to sickle.
		Hemolytic anemia may be related to repeated cycles of sickling and unsickling, which interact to produce irreversible red cell membrane changes, red cell dehydration, and erythrocyte destruction.
	www.blackhealthcare.com /BHC/SickleCell/Description.asp (1008 words)

	Sickle Cell Anemia (Sickle Cell Disease) Causes, Diagnosis, Symptoms, Treatments on MedicineNet.com (Site not responding. Last check: 2007-10-22)
		Sickle cell anemia (sickle cell disease) is a disorder of the blood caused by an inherited abnormal hemoglobin (an oxygen-carrying protein within the red blood cells).
		Sickle cell anemia is inherited as an autosomal (meaning that the gene is not linked to a sex chromosome) recessive condition whereas sickle cell trait is inherited as an autosomal dominant trait.
		In order for sickle cell anemia to occur, a sickle cell gene must be inherited from both the mother and the father, so that the child has two sickle cell genes.
	www.medicinenet.com /sickle_cell/article.htm (466 words)

	Anemia, sickle cell definition - Medical Dictionary definitions of popular medical terms (Site not responding. Last check: 2007-10-22)
		Hemoglobin is the molecule in red blood cells that transports oxygen from the lungs to the farthest reaches of the body.
		Sickle cell anemia is caused by an error in a gene that makes the beta globin chain of hemoglobin.
		Instead, the sickle gene may be a serious threat to the carrier's children, who may inherit two abnormal sickle hemoglobin genes and have sickle cell anemia.
	www.medterms.com /script/main/art.asp?articlekey=9377 (454 words)

	Evolution: Library: A Mutation Story
		Doctors noticed that patients who had sickle cell anemia, a serious hereditary blood disease, were more likely to survive malaria, a disease which kills some 1.2 million people every year.
		The sickle cell mutation is a like a typographical error in the DNA code of the gene that tells the body how to make a form of hemoglobin (Hb), the oxygen-carrying molecule in our blood.
		Scientists believe the sickle cell gene appeared and disappeared in the population several times, but became permanently established after a particularly vicious form of malaria jumped from animals to humans in Asia, the Middle East, and Africa.
	www.pbs.org /wgbh/evolution/library/01/2/l_012_02.html (600 words)

	Sickle cell anemia
		Sickle cell anemia is caused by a mistake in the gene that tells your body to make hemoglobin — the red, iron-rich protein that gives blood its red color.
		The sickle cell gene is passed from generation to generation in a pattern of inheritance called autosomal recessive inheritance.
		For a baby to be born with sickle cell anemia, both parents have to carry the sickle cell gene.
	www.cnn.com /HEALTH/library/DS/00324.html (3361 words)

	What Is Sickle Cell Anemia?
		Sickle cell anemia is the most common sickle cell disorder.
		Sickle cell anemia may injure the body parts, especially the bones, central nervous system, lungs, liver and spleen.
		Persons who inherit the sickling gene from only one parent do not get sickle cell anemia, but they can transmit the abnormal gene to their children.
	www.sicklecellna.org /what_is_sickle_cell_anemia.htm (454 words)

	Sickle Cell Anemia
		SICKLE CELL ANEMIA (SCA) is the most common inherited blood disorder in the United States, affecting about 72,000 Americans or 1 in 500 African Americans.
		SCA is characterized by episodes of pain, chronic hemolytic anemia and severe infections, usually beginning in early childhood.
		SCA is an autosomal recessive disease caused by a point mutation in the hemoglobin beta gene (HBB) found on chromosome 11p15.4.
	www.ncbi.nlm.nih.gov /disease/sickle.html (302 words)

	Sickle Cell Anemia - DrGreene.com
		Sickle cell disease is caused by a genetic variation of hemoglobin, the molecule that carries oxygen in the red blood cell.
		Sickle cell anemia often causes other problems as well, including jaundice, strokes, liver disease, kidney disease, gallstones, heart disease, eye problems, painful erections, and poor growth.
		Sickle cell anemia is tested for on many newborn screening tests so that it can be diagnosed before children develop symptoms.
	www.drgreene.com /21_1186.html (762 words)

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